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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
133 Results for "
CD34+/CD38- subpopulation
" in MedChemExpress (MCE) Product Catalog:
Products (133)
133 Results for "CD34+/CD38- subpopulation" in MCE Product Catalog:
Cat. No.: HY-P8F015I
Synonyms: CD34,CD34-APC,581
Cat. No.: HY-182345
NOTA-MK0159 is a NOTA (HY-134418) and MK0159 (HY-150508) conjugate. NOTA-MK0159 inhibits human and mouse CD38 with IC50 values of 72.58 and 7.55 nM. NOTA-MK0159 coupled with radioactive elements acts as a imaging agent with specific uptake in CD38-positive multiple myeloma cells, enabling noninvasive whole-body assessment of CD38 expression in multiple myeloma xenografts. NOTA-MK0159 can be used for the research of multiple myeloma .
Cat. No.: HY-184021
Target:
Research Areas:
A-8531 is an orally active CD38 inhibitor with IC50 values of 1.10 nM against human CD38, IC50 values of 2.93 nM against mouse CD38, and a human Ka of 0.32 nM. A-8531 exerts its inhibitory activity via its 4-pyridine reactive warhead interacting with the CD38 substrate NAD +, and binds stably to CD38 only in the presence of NAD +, with a binding KD of 0.32 nM as detected by SPR. A-8531 dose-dependently increases NAD + levels in mouse skin, lung and liver tissues, while simultaneously reducing the contents of NAM and ADPR in these tissues. A-8531 derivative A-3190 (HY-184206) has blood-brain barrier penetration. A-8531 can be used in studies related to neurodegenerative diseases .
Cat. No.: HY-P8F015B
Synonyms: CD34,CD34-AF488,581
Cat. No.: HY-P8F015H
Synonyms: CD34,CD34-AF647,581
Cat. No.: HY-P8F015K
Synonyms: CD34,CD34-AF700,581
Cat. No.: HY-P8F015L
Synonyms: CD34,CD34-PC Blue,581
Cat. No.: HY-P991914
Cat. No.: HY-184206
Target:
Research Areas:
A-3190 is an orally active, blood-brain barrier permeable CD38 inhibitor, with an IC50 of 7.25 nM against human CD38 and 1.24 nM against mouse CD38. A-3190 is a derivative of A-8531 (HY-184021), and it forms covalent adducts with NAD + in the presence of CD38. A-3190 acts as an inducer of NAD + levels and an inhibitor of NAM and ADPR levels. A-3190 increases NAD + levels in the skin, lung, liver and brain of rodents, while reducing NAM and ADPR levels in brain tissues. A-3190 can be used in research related to multiple sclerosis, Parkinson's disease and Alzheimer's disease .
Cat. No.: HY-P8F015D
Synonyms: CD34,CD34-PE-Cy7,581
Cat. No.: HY-P8F015E
Synonyms: CD34,CD34-PE-CF596,581
Cat. No.: HY-P8F015J
Synonyms: CD34,CD34-APC-Cy7,581
Cat. No.: HY-P8F016A
Synonyms: CD38,CD38-FITC,HB-7
Cat. No.: HY-P8F016C
Synonyms: CD38,CD38-PE,HB-7
Cat. No.: HY-P8F016F
Synonyms: CD38,CD38-PerCP,HB-7
Cat. No.: HY-P8F016I
Synonyms: CD38,CD38-APC,HB-7
Cat. No.: HY-P12276
CDR3a23 is a CD38 inhibitor and apoptosis inducer (human Kd = 630 nM) that binds to CD38 epitope 2 to block its function, induces apoptosis and G1 phase cell cycle arrest, thereby inhibiting cell growth. CDR3a23 can be used in research on hematological malignancies .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
