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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
97 Results for "
IDH
" in MedChemExpress (MCE) Product Catalog:
Products (97)
97 Results for "IDH" in MCE Product Catalog:
Cat. No.: HY-RS29086
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Idh3a Rat Pre-designed siRNA Set A contains three designed siRNAs for Idh3a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06534
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IDH3B Human Pre-designed siRNA Set A contains three designed siRNAs for IDH3B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06535
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IDH3G Human Pre-designed siRNA Set A contains three designed siRNAs for IDH3G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Isocitrate dehydrogenase, Microorganism (IDH) (EC 1.1.1.42) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P) + to NAD(P)H, it plays important roles in cellular metabolism .
Cat. No.: HY-164542
CAS No.: 2071196-10-4
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TQ05310 is an orally available inhibitor of IDH2 mutants, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutants. TQ05310 inhibits the production of 2-hydroxyglutarate (2-HG) and induces differentiation of cells expressing IDH2-R140Q and IDH2-R172K by inhibiting the enzymatic activity of mutant IDH2. TQ05310 can be used for the study of acute myeloid leukemia .
Cat. No.: HY-RS29087
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Idh3g Rat Pre-designed siRNA Set A contains three designed siRNAs for Idh3g gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-121736
CAS No.: 1446501-77-4
Synonyms: AGI-026
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AGI-12026 is brain-penetrant dual inhibitor of mutant IDH1 and 2. AGI-12026 shows partial inhibition of the IDH1-R132H homodimer as allosteric modulators. AGI-12026 has the potential for research of glioma .
Cat. No.: HY-18690S
CAS No.: 2095569-76-7
Synonyms: AG-221-d6
Cat. No.: HY-121916
CAS No.: 1355446-05-7
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ML309 is a highly selective and potent inhibitor of the R132H mutant isocitrate dehydrogenase 1 (IDH1 R132H), with an IC50 of 96 nM. ML309 is a competitive inhibitor of α-KG, with a Ki value of 156 nM, and its inhibitory activity against the wild-type IDH1 is greater than 35 μM. ML309 effectively reduces the production of the tumor metabolite 2-HG in U87MG cells. ML309 can be used as a chemical probe to study the role of the mutant IDH1 in cancer .
Cat. No.: HY-N12390
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Cat. No.: HY-175770
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mIDH1-IN-2 is a brain-penetrant isocitrate dehydrogenase 1 (IDH1) inhibitor. mIDH1-IN-2 shows subnanomolar potency against IDH1 R132H and R132C (IC50 = 80.0 and 58.0 nM) and minimal activity against wt-IDH1/2. mIDH1-IN-2 also inhibits PDK1 (IC50 = 0.61 μM) and reduces PDH phosphorylation dose-dependently. mIDH1-IN-2 can inhibit cells proliferation, induces S phase arrest and promotes apoptosis. mIDH1-IN-2 can be used for the research of cancer, such as glioma .
Cat. No.: HY-18690AR
CAS No.: 1650550-25-6
Synonyms: AG-221 mesylate (Standard)
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Enasidenib (mesylate) (Standard) is the analytical standard of Enasidenib (mesylate). This product is intended for research and analytical applications. Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes.
Cat. No.: HY-143234
CAS No.: 2757155-96-5
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mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC50 of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research .
Cat. No.: HY-120181
CAS No.: 1448346-43-7
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AGI-14100 is a metabolically stable and orally available mIDH1 inhibitor (IC50=6 nM). The pharmacochemical optimization of AGI-14100 is aimed at eliminating hPXR activation, resulting in the final drug candidate AG-120. AG-120 can be used in the study of cancers carrying IDH1 mutations. The discovery and development of AGI-14100 can be used for further studies of mutant isocitrate dehydrogenase 1 (mIDH1) inhibitors .
Cat. No.: HY-104036R
CAS No.: 1628805-46-8
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IDH-305 (Standard) is the analytical standard of IDH-305 (HY-104036). This product is intended for research and analytical applications. IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1 (R132) mutation. IDH-305 exhibits greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50= 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (IDH1WT)) .
Cat. No.: HY-RS22568
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Idh3g Mouse Pre-designed siRNA Set A contains three designed siRNAs for Idh3g gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P70214A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IDH1; NADP+-Specific Isocitrate Dehydrogenase; Isocitrate Dehydrogenase (NADP(+)) 1; Isocitrate Dehydrogenase 1 (NADP+); Oxalosuccinate Decarboxylase; Epididymis Secretory Protein Li 26; NADP(+)-Specific ICDH; Isocitrate Dehydrogenase (NADP(+)); Isocitrat
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
