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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
143 Results for "
Platelet-activating factor
" in MedChemExpress (MCE) Product Catalog:
Products (143)
143 Results for "Platelet-activating factor" in MCE Product Catalog:
Cat. No.: HY-134101
CAS No.: 78858-42-1
Research Areas:
2-O-Ethyl PAF C-16 is a homolog of PAF and a competitive ligand for PAF receptor (Platelet-activating Factor Receptor (PAFR)). 2-O-Ethyl PAF C-16 inhibits the binding of the PAF antagonist WEB 2086 (HY-108634) to the PAF receptor with an IC50 of 21 nM .
Cat. No.: HY-134070
CAS No.: 78858-44-3
Synonyms: ET-18-O-OCH3
Target:
Research Areas:
2-O-Methyl PAF C-16 (ET-18-O-OCH3), a structural analog of the mediator of inflammation platelet-activating factor (PAF), is a cytotoxic ether lipid. 2-O-Methyl PAF C-16 stimulates TNF-α release in murine macrophages .
Cat. No.: HY-19126
CAS No.: 140466-18-8
Research Areas:
CL-184005 is an antagonist for platelet-activating factor (PAF), that inhibits the PAF-induced platelet aggregation with IC50 of 600 nM and 510 nM, in human and rabbit platelet-rich plasma. CL-184005 protects the rats from endotoxin-induced gastrointestinal damage and hypotension. CL-184005 exhibits potential attenuating Gram-negative bacterial sepsis .
Cat. No.: HY-W027544S
Synonyms: 7-Methoxycoumarin-4-acetic acid-d3
Cat. No.: HY-101594
CAS No.: 116289-53-3
Synonyms: RP 59227
Research Areas:
Tulopafant is a platelet activating factor (PAF) antagonist.
Cat. No.: HY-108634S
CAS No.: 1185101-22-7
Synonyms: WEB 2086-d8
Cat. No.: HY-119035
CAS No.: 115406-25-2
Research Areas:
R-75317 is a specific platelet-activating factor (PAF) antagonist. R-75317 can prevent the decline in creatinine clearance (Ccr) in a rat model of glomerulonephritis induced by the injection of antibodies extracted from rabbits against rat glomerular basement membrane (GBM) antigens, delay the onset of proteinuria, and improve glomerular hypertrophy, mesangial matrix proliferation, and interstitial fibrosis. R-75317 may be useful in the study of glomerulonephritis .
Cat. No.: HY-14162
CAS No.: 936349-47-2
Target:
Research Areas:
AM103 (free acid) is a selective FLAP inhibitor that can block the first step of the LT pathway, which is 5-LO activation. AM103 (free acid) can inhibit the production of LTB4 and cysteinyl leukotrienes (CysLT). AM103 (free acid) has anti-inflammatory activity in a mouse model of chronic lung inflammation and can extend the survival time of mice injected with platelet-activating factor. AM103 (free acid) can be used for research on respiratory diseases such as asthma .
Cat. No.: HY-176466
CAS No.: 143484-41-7
Research Areas:
ST-899 is a novel platelet-activating factor (PAF) receptor antagonist. ST-899 can significantly reduce the mortality of mice with endotoxin (LPS)-induced shock. ST-899 can significantly inhibit the increase in serum tumor necrosis factor (TNF) levels induced by LPS, but has no effect on interleukin-6 (IL-6). The regulatory mechanism of ST-899 is to block the positive feedback loop between PAF and TNF, thereby reducing the inflammatory response. ST-899 can be used to study inflammatory diseases such as septic shock .
Cat. No.: HY-123397
CAS No.: 133330-43-5
Research Areas:
SCH-44643 is an orally active platelet activating factor (PAF) and histamine antagonist .
Cat. No.: HY-118779
CAS No.: 93772-08-8
Cat. No.: HY-141612
CAS No.: 91021-63-5
Research Areas:
Pyrrolidino PAF C-16 is a platelet activating factor ( PAF ) analogue that has hypohematic effects .
Cat. No.: HY-132190
CAS No.: 137566-83-7
Synonyms: 1-O-Hexa-decyl-2-acetyl-sn-glycero-3-phospho(N,N,N-trimethyl)-hexanolamine
Research Areas:
Hexanolamino PAF C-16 (1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho (N,N,N trimethyl) hexanolamine) is a Platelet-activating Factor Receptor (PAFR) Modulator with partial agonist activity. Hexanolamino PAF C-16 induces platelet aggregation and macrophage production but fails to increase [Ca2+]i in platelets, suggesting that PAF receptors may interact with PAF receptors through Ca 2+-dependent and -independent pathways. Related to platelet aggregation .
Cat. No.: HY-121394
CAS No.: 113787-28-3
Research Areas:
L-659,989 is an orally active, extremely potent, selective and competitive platelet activating factor (PAF) receptor antagonist .
Cat. No.: HY-N17414
CAS No.: 1457972-74-5
Cat. No.: HY-101654
CAS No.: 132579-32-9
Synonyms: BN 50730; LAU-8080
Research Areas:
Rocepafant (BN 50730) is a specific platelet activating factor (PAF) antagonist. Rocepafant can be used in rheumatoid arthritis and nervous system research .
Cat. No.: HY-19084
CAS No.: 120555-31-9
Research Areas:
Ro-24-0238 is an antagonist of platelet activating factor (PAF) and inhibitor of thromboxane synthesis, used for lessening the inflammation and damage resulting from a local release of PAF.
Cat. No.: HY-N3436
CAS No.: 99340-07-5
Cat. No.: HY-100316
CAS No.: 139401-45-9
Target:
Research Areas:
CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively.
Cat. No.: HY-176019
Research Areas:
Methylcarbamyl PAF C-8 is resistant to the degradation function of platelet-activating factor acetylhydrolase (PAF-AH). It has a half-life of more than 100 minutes in platelet-poor plasma and possesses the activity of inducing platelet aggregation. In NRK-49 cells overexpressing the PAF receptor, Methylcarbamyl PAF C-8 can induce the expression of c-myc and c-fos, and activate mitogen-activated protein kinase (MAPK). Additionally, Methylcarbamyl PAF C-8 can induce cell cycle arrest in the G1 phase. Methylcarbamyl PAF C-8 holds promise for research in the fields of cardiovascular diseases and anti-cancer therapy .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
