1. GPCR/G Protein
  2. Leukotriene Receptor
  3. CP-96486

CP-96486 

Cat. No.: HY-100316
Handling Instructions

CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively.

For research use only. We do not sell to patients.

CP-96486 Chemical Structure

CP-96486 Chemical Structure

CAS No. : 139401-45-9

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10 mg USD 3847 Get quote

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Description

CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively.

IC50 & Target[1]

LTD4

20 nM (Ki)

PAF receptor

24 nM (Ki)

In Vitro

CP-96486 (CP-96,486) antagonizes 3H-LTD4 binding to guinea pig lung membranes and 3H-PAF binding to rabbit platelets with Ki's of 20 and 24 nM respectively[1].

In Vivo

CP-96486 (CP-96,486) inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50's of 0.27 and 0.26 mg/kg p.o. respectively[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

502.99

Formula

C₃₁H₂₃ClN₄O

CAS No.

139401-45-9

SMILES

CC(N1C2=CC=C(OCC3=CC(/C=C/C4=NC5=CC(Cl)=CC=C5C=C4)=CC=C3)C=C2)=NC6=C1C=CN=C6

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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CP-96486
Cat. No.:
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CP-96486

Cat. No.: HY-100316