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Cat. No.: HY-100316

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CP-96486

CP-96486 is a potent and orally active leukotriene D₄ (LTD₄)/platelet activating factor (PAF) receptor antagonist with K_is of 20 and 24 nM, respectively.

For research use only. We do not sell to patients.

CAS No.: 139401-45-9
Formula: C₃₁H₂₃ClN₄O
Molecular Weight:502.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CP-96486 Chemical Structure

CAS No.: 139401-45-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

CP-96486 is a potent and orally active leukotriene D₄ (LTD₄)/platelet activating factor (PAF) receptor antagonist with K_is of 20 and 24 nM, respectively.

IC₅₀ & Target

^[1]

LTD₄

20 nM (Ki)

PAF receptor

24 nM (Ki)

All Leukotriene Receptor Isoforms :

In Vitro

CP-96486 (CP-96,486) antagonizes ³H-LTD4 binding to guinea pig lung membranes and ³H-PAF binding to rabbit platelets with K_i's of 20 and 24 nM respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

CP-96486 (CP-96,486) inhibits iv LTD₄- and iv PAF-induced bronchoconstriction in guinea pigs with ED₅₀'s of 0.27 and 0.26 mg/kg p.o. respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 139401-45-9
Molecular Weight 502.99
Formula C₃₁H₂₃ClN₄O
SMILES

CC(N1C2=CC=C(OCC3=CC(/C=C/C4=NC5=CC(Cl)=CC=C5C=C4)=CC=C3)C=C2)=NC6=C1C=CN=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. A.Marfat,et al. The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4(LTD4)/platelet activating factor (PAF) receptor antagonists.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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