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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
139 Results for "
Ca2 release
" in MedChemExpress (MCE) Product Catalog:
Products (139)
139 Results for "Ca2 release" in MCE Product Catalog:
Cat. No.: HY-B0596S
Synonyms: TA-0910-13C,d3
Cat. No.: HY-142050
CAS No.: 950665-05-1
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Synonyms: Riparin III
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Riparin is a nonspecific smooth muscle relaxant. Riparin exerts spasmolytic effect by inhibiting Ca 2+ influx and inhibiting the release of intracellular calcium ion stores .
Cat. No.: HY-N10512
CAS No.: 75645-24-8
Synonyms: Gg4
Category:
Polysaccharides Neurological Disease Endogenous metabolite Disease Research Fields Saccharides
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Cat. No.: HY-A0057AS2
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Cat. No.: HY-133596
CAS No.: 65281-77-8
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12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca 2+-activated K + (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca 2+ and stimulates transmitter release .
Cat. No.: HY-100168R
CAS No.: 85233-19-8
Cat. No.: HY-120699
CAS No.: 1337920-46-3
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RO5488608 is a negative allosteric metabotropic modulator of glutamate receptor 2/3. RO5488608 inhibits LY354740 (HY-18941)-induced intracellular Ca 2+ release and can be used for study of antidepressant .
Cat. No.: HY-100168AR
CAS No.: 126824-24-6
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BAPTA tetrasodium (Standard) is the analytical standard of BAPTA tetrasodium. This product is intended for research and analytical applications. BAPTA tetrasodium is a selective and cell-impermeant chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca 2+ release from intracellular stores or influx via Ca 2+-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators .
Cat. No.: HY-106837
CAS No.: 117279-73-9
Synonyms: Y 24180
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Israpafant (Y-24180) is a potent, selective and long-acting platelet activation factor (PAF) receptor antagonist with IC50s of 0.84 nM and 3.84 nM against PAF-induced human and rabbit platelet aggregation, respectively. Israpafant stimulates both extracellular Ca 2+ influx and intracellular Ca 2+ release in prostate cancer cells. Israpafant suppresses the allergic cutaneous reactions including eosinophilia, cytokine production, edema and erythema in mice .
Cat. No.: HY-172321
Synonyms: Nicotinic acid 1,N6-ethenoadenine dinucleotide phosphate sodium
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Etheno-NAADP (Nicotinic acid 1,N6-ethenoadenine dinucleotide phosphate) sodium is a fluorescent product of NAADP (HY-103317). Etheno-NAADP sodium could activate Ca 2+ release from sea urchin egg homogenates with an EC50 of 5 µM (Ex/Em = 275/410 nm) .
Cat. No.: HY-P3168
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Cat. No.: HY-167091
CAS No.: 88430-50-6
Synonyms: (Rac)-TRK-100 free acid; (Rac)-ML 1229
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(Rac)-Beraprost ((Rac)-ML 1229) is an orally active prostacyclin analog that inhibits the release of Ca 2+ from intracellular storage sites by binding to prostacyclin membrane receptors (Prostaglandin Receptor), leading to relaxation of smooth muscle cells and vasodilation. Beraprost has vasodilatory, antiplatelet, and cytoprotective effects, making it promising for research in the field of cardiovascular diseases, such as thromboangiitis obliterans and atherosclerosis .
Cat. No.: HY-15018A
CAS No.: 785048-28-4
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SSR126768A free base is an orally active antagonist for oxytocin receptor, with Ki of 0.44 nM. SSR126768A free base is a tocolytic agent, that antagonizes the Oxytocin (HY-17571)-induced intracellular Ca 2+ increase and prostaglandin release in human uterine smooth muscle cells, inhibits thus the Oxytocin (HY-17571)-induced uterine contraction and delays parturition in pregnant rats in labor .
Cat. No.: HY-Z7721
CAS No.: 88475-69-8
Synonyms: (Rac)-TRK-100; (Rac)-ML 1129 sodium
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(Rac)-Beraprost ((Rac)-ML 1129) sodium is a racemic isomer of Beraprost sodium (HY-13569A). Beraprost sodium is an orally active prostacyclin analog that inhibits the release of Ca 2+ from intracellular storage sites by binding to prostacyclin membrane receptors (Prostaglandin Receptor), leading to relaxation of smooth muscle cells and vasodilation. Beraprost sodium has vasodilatory, antiplatelet, and cytoprotective effects, making it promising for research in the field of cardiovascular diseases, such as thromboangiitis obliterans and atherosclerosis .
Cat. No.: HY-111208R
CAS No.: 883098-58-6
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CCT129957 (Standard) is the analytical standard of CCT129957 (HY-111208). This product is intended for research and analytical applications. CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM .
Cat. No.: HY-101379AR
CAS No.: 51116-01-9
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8-Bromo-cGMP (sodium) (Standard) is the analytical standard of 8-Bromo-cGMP (sodium) (HY-101379A). This product is intended for research and analytical applications. 8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator. 8-Bromo-cGMP sodium significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+ . 8-Bromo-cGMP sodium has antinociceptive effects and results in vasodilator responses .
Cat. No.: HY-107543R
CAS No.: 634207-53-7
Synonyms: 8-CPT-2'-O-Me-CaMP sodium (Standard)
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8-pCPT-2′-O-Me-cAMP sodium (Standard) is the analytical standard of 8-pCPT-2′-O-Me-cAMP (sodium) (HY-107543). This product is intended for research and analytical applications. 8-pCPT-2′-O-Me-cAMP (8-CPT-2'-O-Me-cAMP) sodium, an analog of cAMP, is an activator of exchange proteins activated by cAMP (Epac). 8-pCPT-2′-O-Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 >10 μM). 8-pCPT-2′-O-Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro. 8-pCPT-2′-O-Me-cAMP sodium is a Rap1 activator. 8-pCPT-2′-O-Me-cAMP sodium enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration .
Cat. No.: HY-183907
CAS No.: 89943-82-8
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Cicletanine is a voltage-dependent Ca 2+ channel inhibitor. Cicletanine inhibits α-adrenoceptor-mediated Ca 2+ release pathway, and shows vasodilatory effects on isolated vascular smooth muscle. Cicletanine directly stimulates lysosomal and cytoplasmic cholesteryl ester hydrolase activity. Cicletanine can be used for the research of hypertension .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
