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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
108 Results for "
LXR
" in MedChemExpress (MCE) Product Catalog:
Products (108)
108 Results for "LXR" in MCE Product Catalog:
Cat. No.: HY-177890
CAS No.: 3031463-59-6
UAB116 is a Liver X Receptor (LXR)/Retinoid X Receptor (RXR) agonist. UAB116 can decreases metastatic phenotype in hepatoblastoma by inhibiting the Wnt/β-Catenin pathway via upregulation of TRIM29. UAB116 can reduce proliferation, stemness and invasiveness of metastatic hepatoblastoma cells .
Cat. No.: HY-169279
Target:
Research Areas:
PROTAC PXR degrader-1 is a PROTAC degrader targeting PXR, with a DC50 value of 49.8 nM in SNU-C4 3xFLAG-PXR KI cells. PROTAC PXR degrader-1 exhibits selectivity towards CAR, VDR, FXR, LXRα and LXRβ. PROTAC PXR degrader-1 induces the formation of a ternary complex with PXR and VHL, triggering proteasomal degradation of PXR. PROTAC PXR degrader-1 reduces both agonist-induced and basal PXR-mediated CYP3A4 promoter activation, and decreases the expression of endogenous CYP3A4 gene in cancer cells. PROTAC PXR degrader-1 enhances the cytotoxic effect of paclitaxel on cancer cells. PROTAC PXR degrader-1 can be used for the research of colorectal cancer .
Cat. No.: HY-N0835R
CAS No.: 34080-08-5
Synonyms: 20(S)-APPT (Standard); g-PPT (Standard)
Cat. No.: HY-115780
CAS No.: 1090785-30-0
Research Areas:
E17110 is a liver X receptor β (LXRβ) agonist with an EC50 of 0.72 μM. E17110 can increase the expression of ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) in RAW264.7 macrophages. E17110 also reduce cellular lipid accumulation and promoted cholesterol efflux. E17110 can be used for the research of cardiovascular disease, such as atherosclerosis .
Cat. No.: HY-178959
Target:
Research Areas:
FXR agonist 13 is a selective, orally active, potent FXR agonist (EC50 = 0.097 μM) and has favorable hepatic microsomal metabolic stability. FXR agonist 13 exhibits moderate affinity for FXR-LBD upon direct binding (KD = 14.74 μM). FXR agonist 13 displays good selectivity against related nuclear receptors, including LXRα/β, PPARα/γ/δ, PXR, and TGR5. FXR agonist 13 can be used for the study of metabolic-associated steatohepatitis (MASH) .
Category:
Cat. No.: HY-119831
CAS No.: 71294-60-5
Target:
NF-κB CDK PPAR Akt mTOR LXR Reactive Oxygen Species (ROS) Apoptosis Wnt Interleukin Related p38 MAPK ERK JNK
Research Areas:
Rohitukine is an orally active CDK9/T1 inhibitor with an IC50 of 0.3 μM. Rohitukine blocks ATP binding sites of CDK2/A and CDK9/T1, suppresses PPARγ, AKT, mTOR, C/EBPα, SREBP-2, and NF-κB signaling, and increases hepatic LXRα expression. Rohitukine induces S-phase cell cycle arrest, ROS generation, apoptosis, and exhibits anti-inflammatory activity. Rohitukine can be used for the research of leukemia, pancreatic cancer, prostate cancer, breast cancer, CNS cancer, ovarian cancer, lung cancer, dyslipidemia, inflammatory diseases, inflammatory bowel disease, and arthritis .
Cat. No.: HY-108688R
CAS No.: 1221277-90-2
Target:
Research Areas:
GSK2033 (Standard) is the analytical standard of GSK2033 (HY-108688). This product is intended for research and analytical applications. GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively.
Cat. No.: HY-RS19726
Target:
Research Areas:
Nr1h2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nr1h2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184474
Research Areas:
AU403 is a potent, brain-penetrant, isoform-selective LXRβ/PPARδ dual agonist (EC50 ≈ 45 nM for LXRβ and EC50 ≈ 40 nM for PPARδ). AU403 is designed to bypass LXRα-driven hepatotoxicity. AU403 significantly improves cognitive functions and reduces amyloid-β plaque burden in 3xTg-AD mice. AU403 is a promising dual-acting agonist for the research of Alzheimer’s disease .
Cat. No.: HY-P701404
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NR1H3; Liver X Receptor Alpha; Nuclear Receptor Subfamily 1 Group H Member 3; CDNA FLJ56172, Highly Similar To Oxysterols Receptor LXR-Alpha; LXR-A; Nuclear Receptor Subfamily 1, Group H, Member 3; RLD-1; Liver X Nuclear Receptor Alpha Variant 1; LXRa; Li
Species:
Human
Source:
E. coli
Cat. No.: HY-P701405
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NR1H3; Liver X Receptor Alpha; Nuclear Receptor Subfamily 1 Group H Member 3; CDNA FLJ56172, Highly Similar To Oxysterols Receptor LXR-Alpha; LXR-A; Nuclear Receptor Subfamily 1, Group H, Member 3; RLD-1; Liver X Nuclear Receptor Alpha Variant 1; LXRa; Li
Species:
Human
Source:
E. coli
Cat. No.: HY-160126
CAS No.: 2154373-60-9
27-Norcholestenoic acid is an inverse agonist of LXRβ and LXRα that decreases basal luciferase activity and inhibits agonist-induced transactivation. 27-Norcholestenoic acid induces conformational changes in the AF-2 domain that favor corepressor over coactivator recruitment, thereby destabilizing the active receptor conformation. 27-Norcholestenoic acid downregulates FASN and SREBP-1a/c gene expression .
Cat. No.: HY-182014
CAS No.: 2408041-54-1
Target:
Research Areas:
TLC-2716 is an orally available, gut- and liver-restricted inhibitor against LXRα and LXRβ, with EC50 values of 7 nM and 15 nM, respectively. TLC-2716 represses LXRα/β transcriptional activity, downregulates genes involved in lipogenesis, lipid absorption and lipoprotein metabolism, and preserves peripheral reverse cholesterol transport. TLC-2716 reduces lipid accumulation, suppresses inflammation and fibrotic gene expression, enhances triglyceride-rich lipoprotein clearance, and improves glucose homeostasis and insulin sensitivity. TLC-2716 lowers serum and hepatic triglycerides, plasma cholesterol and other atherogenic lipid profiles in experimental models and humanized liver mice. TLC-2716 can be used for the research of dyslipidemia and related cardiometabolic disorders .
Cat. No.: HY-109073R
CAS No.: 1454288-88-0
Synonyms: ALX-101 (Standard)
Target:
Research Areas:
Rovazolac (Standard) is the analytical standard of Rovazolac (HY-109073). This product is intended for research and analytical applications. Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1.
Cat. No.: HY-111498R
CAS No.: 610318-03-1
Synonyms: Abequolixron hydrochloride (Standard)
Target:
Research Areas:
RGX-104 hydrochloride (Standard) is the analytical standard of RGX-104 (hydrochloride) (HY-111498). This product is intended for research and analytical applications. RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
Cat. No.: HY-10627R
CAS No.: 405911-09-3
Target:
Research Areas:
GW3965 (Standard) is the analytical standard of GW3965 (HY-10627). This product is intended for research and analytical applications. GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
