108 Results for "

LXR

" in MedChemExpress (MCE) Product Catalog:
Products (108)

108 Results for "LXR" in MCE Product Catalog:

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RGX-104 (Standard)
RGX-104 (Standard)
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Cat. No.: HY-111498AR
CAS No.: 610318-54-2
Synonyms: Abequolixron (Standard)
Target:  

Reference Standards LXR

Research Areas:  

Inflammation/Immunology Cancer

RGX-104 (Standard) is the analytical standard of RGX-104 (HY-111498A). This product is intended for research and analytical applications. RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
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FXR agonist 15
FXR agonist 15
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Cat. No.: HY-179703
CAS No.: 2991276-14-1
Target:  

FXR

Research Areas:  

Inflammation/Immunology

FXR agonist 15 is a selective, potent and orally active farnesoid X receptor (FXR) agonist with EC50 of 0.76 μM. FXR agonist 15 exhibits no obvious activation on other nuclear receptors including LXRα/β, PXR, PPARα/β/γ, THR-β, with EC50 values all >10 μM. FXR agonist 15 can alleviate steatosis, lobular inflammation, hepatocyte ballooning and liver fibrosis. FXR agonist 15 can be used for the research of nonalcoholic steatohepatitis (NASH) .
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Acanthoic acid
Acanthoic acid
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Cat. No.: HY-116136
CAS No.: 119290-87-8
Synonyms: NP1302
Category:  

Triterpenes Terpenoids Plants Acanthopanax koreanum Araliaceae Extract

Target:  

LXR FXR AMPK Sirtuin p38 MAPK Acetyl-CoA Carboxylase Cytochrome P450 HIF/HIF Prolyl-Hydroxylase PPAR Caspase PARP Bcl-2 Family Apoptosis

Acanthoic acid (NP1302) is an orally active pimarane-type diterpenoid. Acanthoic acid is isolated from the root bark of Araliaceae family plant Eleutherococcus senticosus (Siberian ginseng). Acanthoic acid activates LXR and FXR. Acanthoic acid activates the AMPK-LKB1, SIRT1, and p38 MAPK signaling pathways and increases the phosphorylation level of ACC. Acanthoic acid downregulates the expression of SREBP-1, CYP2E1, HIF-1α, and PPARγ, and upregulates the expression of PPARα. Acanthoic acid induces Apoptosis by activating Caspase-3, promoting PARP cleavage, and downregulating Bcl-xL. Acanthoic acid exhibits antioxidant, anti-fibrotic, and hepatoprotective effects. It reduces lipid accumulation and lipogenesis. Acanthoic acid is used in studies on non-alcoholic fatty liver disease, alcoholic liver disease, acute promyelocytic leukemia, and Acetaminophen-induced hepatotoxicity .
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Gypenoside LVI
Gypenoside LVI
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Cat. No.: HY-N21887
CAS No.: 105214-48-0
Category:  

Tetracyclic Triterpenoids Terpenoids Cucurbitaceae Extract Plants Gynostemma pentaphyllum (Thunb.) Makino

Target:  

ERK JNK NOD-like Receptor (NLR) PCSK9 LXR Interleukin Related

Gypenoside LVI is an orally active dammarane-type triterpenoid compound found in Gynostemma pentaphyllum. Gypenoside LVI inhibits ERK and JNK phosphorylation, the NLRP3 inflammasome, and modulates M1 to M2 microglial polarization. Gypenoside LVI downregulates PCSK9 expression through a SREBP-independent pathway. Gypenoside LVI promotes cholesterol efflux via ABCG1 and SRB1, upregulates LXRα-mediated reverse cholesterol transport, and attenuates foam cell formation by reducing lipid accumulation and cholesterol uptake. Gypenoside LVI inhibits IL-6 and IL-1β secretion, reduces oxidative stress, neuroinflammation, microglial and astrocyte activation, and inhibits LPS-induced microglial proliferation. Gypenoside LVI can be used for research on atherosclerosis, hypercholesterolemia, depression, and non-small cell lung cancer .
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2,4-Di-tert-butylphenol (Standard)
2,4-Di-tert-butylphenol (Standard)
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Cat. No.: HY-W014589R
CAS No.: 96-76-4
Synonyms: 2,4-DTBP (Standard)
Category:  

Microorganisms Monophenols Phenols Endogenous metabolite

Target:  

Reference Standards Endogenous Metabolite Fungal Apoptosis RAR/RXR Amyloid-β

2,4-Di-tert-butylphenol (Standard) is the analytical standard of 2,4-Di-tert-butylphenol (HY-W014589). This product is intended for research and analytical applications. 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities, and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of pharmaceuticals and fragrances .
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2,4-Di-tert-butylphenol-d19
2,4-Di-tert-butylphenol-d19
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Cat. No.: HY-W014589S
CAS No.: 1577233-55-6
Synonyms: 2,4-DTBP-d19
2,4-Di-tert-butylphenol-d19 (2,4-DTBP-d19) is the deuterium labeled 2,4-Di-tert-butylphenol (HY-W014589). 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances .
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2,4-Di-tert-butylphenol-d21
2,4-Di-tert-butylphenol-d21
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Cat. No.: HY-W749327
CAS No.: 1413431-25-0
Synonyms: 2,4-DTBP-d21
2,4-Di-tert-butylphenol-d21 (2,4-DTBP-d21) is the deuterium labeled 2,4-Di-tert-butylphenol (HY-W014589). 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances .
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5,7-Dihydroxychromone (Standard)
5,7-Dihydroxychromone (Standard)
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Cat. No.: HY-N1970R
CAS No.: 31721-94-5
Category:  

Flavonoids Phenols Polyphenols Plants Other Families Extract Isoflavones

Target:  

Reference Standards Keap1-Nrf2 Caspase PARP Fungal

5,7-Dihydroxychromone (Standard) is the analytical standard of 5,7-Dihydroxychromone (HY-N1970). This product is intended for research and analytical applications. 5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection .
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