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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1223 Results for "
stem
" in MedChemExpress (MCE) Product Catalog:
Products (1223)
1223 Results for "stem" in MCE Product Catalog:
Referencia número: HY-P85841
Synonyms: C Kit; c-Kit; c-Kit Ligand; CD117; Kit; Kit Ligand; KIT oncogene; KIT proto oncogene receptor tyrosine kinase; KIT_HUMAN; Mast cell growth factor receptor; Mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; Proto oncogene c Kit; Proto oncogene tyrosine protein kinase Kit; Proto-oncogene c-Kit; SCF Receptor; SCFR; soluble KIT variant 1; Steel Factor Receptor; stem cell factor receptor; tyrosine protein kinase Kit; Tyrosine-protein kinase Kit; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Referencia número: HY-P86802
Synonyms: AC133 antibody; Antigen AC133 antibody; CD133 antibody; CORD12 antibody; Hematopoietic stem cell antigen antibody; hProminin antibody; MCDR2 antibody; MSTP061 antibody; OTTHUMP00000217744 antibody; OTTHUMP00000217745 antibody; AC133 antibody; Antigen AC133 antibody; CD133 antibody; CORD12 antibody; Hematopoietic stem cell antigen antibody; hProminin antibody; MCDR2 antibody; MSTP061 antibody; OTTHUMP00000217744 antibody; OTTHUMP00000217745 antibody; OTTHUMP00000217746 antibody; PROM1 antibody; PROM1_HUMAN antibody; Prominin I antibody; Prominin like 1 antibody; Prominin like protein 1 precursor antibody; Prominin mouse like 1 antibody; Prominin-1 antibody; Prominin-like protein 1 antibody; Prominin1 antibody; PROML1 antibody; RP41 antibody; STGD4 antibody;
Referencia número: HY-10182AR
No. CAS: 1797989-42-4
Synonyms: CHIR-99021 monohydrochloride (Standard); CT99021 monohydrochloride (Standard)
Laduviglusib (monohydrochloride) (Standard) is the analytical standard of Laduviglusib (monohydrochloride). This product is intended for research and analytical applications. Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy .
Referencia número: HY-103701R
No. CAS: 23313-12-4
Synonyms: 2-Phospho-L-ascorbic acid (Standard); LAA2P (Standard)
Referencia número: HY-10996
No. CAS: 1262770-73-9
Áreas de investigación:
KHS101 is a blood-brain barrier-penetrant anticancer agent that primarily functions by inhibiting HSPD1 (IC50 = 14.4 μM) and TACC3 across different cellular backgrounds. KHS101 promotes the aggregation of HSPD1 with client proteins, destabilizes TACC3, and reduces the levels of TACC3, Aurora A and PLK1. KHS101 induces autophagy, apoptosis, cell cycle exit and neuronal differentiation; it suppresses cancer cell growth, motility, EMT and stemness; it also impairs mitochondrial bioenergetics and glycolysis in glioblastoma cells. KHS101 can be used in research related to glioblastoma multiforme and breast cancer .
CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor (IC50=11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis, arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC .
Referencia número: HY-129115
No. CAS: 897613-29-5
Target:
Áreas de investigación:
S1QEL1.1 is a small molecule inhibitor that specifically inhibits the generation of superoxide and hydrogen peroxide at the IQ site during reverse electron transfer in mitochondrial respiratory chain complex I (Complex I), with an IC50 of 0.07 μM. S1QEL1.1 can significantly reduce the activation of cysteine-aspartic protease (caspase) triggered by endoplasmic reticulum stress. S1QEL1.1 helps to decrease excessive proliferation of stem cells by inhibiting the Reactive Oxygen Species signaling pathway initiated by endoplasmic reticulum stress .
Referencia número: HY-181560
No. CAS: 2759011-75-9
Áreas de investigación:
SLD1121 is an agonist of the Wnt/β-catenin signaling pathway that enhances Wnt signaling by targeting LRP6 (Kd: 4.52-7.49 nM). SLD1121 interacts with the intracellular domain of LRP6, stabilizes LRP6, promotes its nuclear translocation, and facilitates its binding to β-catenin, TCF4 or LEF1 in the nucleus, thereby inducing the expression of Wnt-regulated genes and stem cell-related genes. SLD1121 induces the transition of hair follicles from telogen to anagen in the mouse hair growth cycle and promotes hair growth in mice. SLD1121 is applicable to hair loss-related research .
Referencia número: HY-N8134
No. CAS: 1809980-25-3
Target:
Referencia número: HY-W714048
Synonyms: CHIR-99021-d4; CT99021-d4
Referencia número: HY-W747491
No. CAS: 1365620-36-5
Triclosan- 13C12 is 13C labeled Triclosan (HY-B1119). Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
Referencia número: HY-K6301
MCE Human iPSC/ESC Cortical Brain Organoid Induction Differentiation Kit is a standardized culture system specifically designed to recapitulate the developmental processes and functional features of the human cerebral cortex through forebrain ventralization-based signaling regulation. By sequentially activating the Wnt/β-catenin pathway and gradually inhibiting BMP/Smad signaling, this system efficiently drives human pluripotent stem cells (PSC) to differentiate into high-purity glutamatergic neurons (VGLUT1/2+ > 85%), while simultaneously promoting the formation of Pax6+/BLBP+ radial glial cells that establish a biomimetic ventricular-zone–like structure.
Referencia número: HY-P991744
Category:
Target:
Referencia número: HY-13739
No. CAS: 58994-96-0
Synonyms: MCNU
Target:
Áreas de investigación:
Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera .
Referencia número: HY-148958
No. CAS: 471918-16-8
Target:
Áreas de investigación:
SNAP-Biotin is a cell-permeable SNAP-tag-targeted labeling reagent. SNAP-Biotin undergoes an irreversible covalent reaction with SNAP-tag to transfer biotin to the tag. SNAP-Biotin enables the detection of SNAP-tag fusion proteins via a streptavidin-HRP immunoblotting system and achieves biotinylation of SNAP-tag fusion proteins. SNAP-Biotin is applicable to triple-negative breast cancer-related research .
Referencia número: HY-174216
No. CAS: 3068830-89-4
Áreas de investigación:
PZL-A is a activator of mitochondrial DNA (mtDNA) synthesis. PZL-A restores wild-type-like activity to mutant forms of polymerase γ (POLγ) with AC50 s of 160 and 20 nM for A467T and G848S. PZL-A activates mtDNA synthesis in cells, enhancing biogenesis of the oxidative phosphorylation machinery and cellular respiration. PZL-A is promising for relieving POLG disease and other severe conditions linked to depletion of mtDNA .
Referencia número: HY-P11809
No. CAS: 79385-97-0
Category:
Target:
Referencia número: HY-P76197
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PROM1; AC133 Antigen; Prev. PROML1; Prominin-1; Prev. STGD4; Stargardt Disease 4 (Autosomal Dominant); Prev. MCDR2; Hematopoietic stem Cell Antigen; CORD12; Macular Dystrophy, Retinal 2; CD133; Prominin (Mouse)-Like 1; AC133; CD133 Isoform H; RP41; CD133
Species:
Rat
Source:
HEK293
Referencia número: HY-160121
No. CAS: 76319-15-8
Synonyms: Patrinoside aglycone
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
