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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
124 Results for "
IL18
" in MedChemExpress (MCE) Product Catalog:
Products (124)
124 Results for "IL18" in MCE Product Catalog:
Cat. No.: HY-P78316
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IL18RAP; IL-1RAcPL; Interleukin 18 Receptor Accessory Protein; CDw218b; AcPL; IL-1R-7; CD218b; IL-1R7; Interleukin-18 Receptor Accessory Protein; Interleukin-18 Receptor Accessory Protein-Like; CD218 Antigen-Like FamILy Member B; Cluster Of Differentiatio
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P72573
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL18RAP; IL-1RAcPL; Interleukin 18 Receptor Accessory Protein; CDw218b; AcPL; IL-1R-7; CD218b; IL-1R7; Interleukin-18 Receptor Accessory Protein; Interleukin-18 Receptor Accessory Protein-Like; CD218 Antigen-Like FamILy Member B; Cluster Of Differentiatio
Species:
Human
Source:
HEK293
Cat. No.: HY-P76425
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: IL18RAP; IL-1RAcPL; Interleukin 18 Receptor Accessory Protein; CDw218b; AcPL; IL-1R-7; CD218b; IL-1R7; Interleukin-18 Receptor Accessory Protein; Interleukin-18 Receptor Accessory Protein-Like; CD218 Antigen-Like FamILy Member B; Cluster Of Differentiatio
Species:
Human
Source:
HEK293
Cat. No.: HY-P705145
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IL18RAP; IL-1RAcPL; Interleukin 18 Receptor Accessory Protein; CDw218b; AcPL; IL-1R-7; CD218b; IL-1R7; Interleukin-18 Receptor Accessory Protein; Interleukin-18 Receptor Accessory Protein-Like; CD218 Antigen-Like FamILy Member B; Cluster Of Differentiatio
Species:
Human
Source:
HEK293
Cat. No.: HY-P10939A
Target:
Research Areas:
Cat. No.: HY-P992238
Target:
Research Areas:
Cat. No.: HY-P992239
Target:
Research Areas:
Cat. No.: HY-P992046
Target:
Research Areas:
Cat. No.: HY-178053
CAS No.: 1191937-43-5
Research Areas:
AHR agonist 10 is a potent AHR agonist (EC50 = 2.01 nM). AHR agonist 10 can elevate the transcript levels of key AHR downstream pathway target genes, including CYP1A1 and CYP1B1. AHR agonist 10 can downregulate the expression levels of CD36, IL-18 and shows low cytotoxicity (>40 μM) to normal cells. AHR agonist 10 can suppress the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, demonstrating that AHR agonist 10 effectively modulate inflammatory responses through AHR dependent signaling pathways. AHR agonist 10 can be used for psoriasis research .
Cat. No.: HY-185311
CAS No.: 3119435-52-5
Research Areas:
NEK7 degrader-3 is an orally active and brain-penetrant NEK7 molecular glue degrader with a DC50 of 33.1 nM. NEK7 degrader-3 mediates interaction between NEK7 and E3 ligase cereblon, promoting proteasomal degradation of NEK7 and attenuating NLRP3 inflammasome-mediated inflammatory responses. NEK7 degrader-3 inhibits caspase-1 activity, cytokine release of IL-1β, IL-1α, and IL-18, and pyroptosis-related plasma membrane permeabilization. NEK7 degrader-3 shows antiinflammatory activity in an LPS (HY-D1056)-induced neuroinflammation mouse model. NEK7 degrader-3 can be used for the research of neuroinflammation .
Cat. No.: HY-NP192
Cat. No.: HY-113298R
CAS No.: 498-23-7
Synonyms: Methylmaleic acid (Standard); Citraconate (Standard)
Cat. No.: HY-189235
CAS No.: 3078735-55-1
Target:
Research Areas:
IHCH-8110 is a peripherally restricted, non-brain-penetrant 5-HT2AR and 5-HT2CR agonist (Ki=47.86 nM) that antagonizes 5-HT2BR. IHCH-8110 induces CXCL10 and IL-18 expression by activating 5-HT2AR on enteric glial cells, thereby promoting CD8 + T cell recruitment and effector polarization, and avoids the risk of cardiac valvulopathy associated with 5-HT2BR activation. IHCH-8110 exhibits a low risk of hERG channel inhibition (IC50=5.96 μM) and is well tolerated, sensitizing immunologically cold colorectal cancer to PD-1 blockade therapy, making it suitable for research related to colorectal cancer .
Cat. No.: HY-130413
CAS No.: 660430-03-5
Synonyms: Neuroprotectin D1; NPD1
Cat. No.: HY-P11935
CAS No.: 2410535-57-6
Target:
Wnt Apoptosis Pyroptosis NOD-like Receptor (NLR) Caspase Bcl-2 Family β-catenin GSK-3 Interleukin Related
Research Areas:
RR-171 is an amino acid polypeptide and an inhibitor of the Wnt signaling pathway. RR-171 reduces the expression levels of Wnt-1, GSK3β and β-catenin. RR-171 induces apoptosis (Apoptosis) in pancreatic cancer cells, which is characterized by an increased Bax/Bcl-2 ratio, activation of Caspase-3/7/9, and increased Cleaved-PARP; this pro-apoptotic effect can be partially reversed by Z-VAD-FMK (HY-16658B). RR-171 also induces pyroptosis (Pyroptosis) in pancreatic cancer cells, which is manifested by activation of the NLRP-3 inflammasome, activation of Caspase-1, cleavage of GSDMD, upregulation of IL-1β and IL-18, and increased LDH release; this pro-pyroptotic effect can be partially reversed by VX-765 (HY-13205). RR-171 inhibits the viability, proliferation and colony formation of pancreatic cancer cells, with low cytotoxicity against normal cells. RR-171 downregulates the expression of Ki-67 and PCNA in tumor tissues in vivo, with favorable biosafety. RR-171 can be used in studies related to pancreatic cancer .
Cat. No.: HY-160793
CAS No.: 501950-47-6
Target:
Research Areas:
NSC80734 is a IL- 18 inhibitor. NSC80734 disrupts hIL-18 binding to the ectromelia virus IL-18BP. NSC80734 inhibits IL-18-induced production of IFN-γ .
Cat. No.: HY-P704113
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Interleukin-18 receptor 1; IL-18R1; CDw218a; IL1RRP; IL-18R-alpha; CD218a
Species:
Virus
Source:
HEK293
Cat. No.: HY-175640
Research Areas:
Troponin-IN-1 is a troponin inhibitor. Troponin-IN-1 protects OGD/R-injured H9c2 cardiomyocytes by reducing LDH leakage, pyroptosis and ROS accumulation. Troponin-IN-1 inhibits NO production and IL-1β/TNF-α/IL-18 release in LPS (HY-D1056)-induced RAW264.7 cells. Troponin-IN-1 acts via caspase-1/GSDMD/IL-18 pathway. Troponin-IN-1 reduces myocardial infarct size in LAD-induced myocardial ischemia/reperfusion (MI/R) male rats. Troponin-IN-1 can be used for the study of myocardial ischemia/reperfusion (MI/R) injury .
Cat. No.: HY-111662
CAS No.: 960119-75-9
Target:
Research Areas:
Fc 11a-2, a benzimidazole compound, is an orally active and potent NLRP3 inflammasome inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS; HY-116282C)-induced murine experimental colitis .
Cat. No.: HY-173234
CAS No.: 1008710-58-4
Target:
Research Areas:
GI-Y2 is an orally active, selective Gasdermin D (GSDMD) inhibitor (Kd = 36.0 μM) with anti-pyroptosis activity. GI-Y2 targets GSDMD, impairs membrane anchoring of GSDMD-NT, and blocks GSDMD‑dependent lipid binding and pore formation. GI-Y2 suppresses GSDMD‑dependent pyroptosis and inflammation, mitigates atherosclerosis and cardiac injury, boosts cell survival, and reduces IL‑1β/IL‑18 secretion. GI-Y2 can be used for the research of atherosclerosis and septic myocardial injury .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
