960119-75-9
Chemical Structure
Fc 11a-2
- CAS No.: 960119-75-9
- Formula:C16H16N2
- Molecular Weight:236.31
IUPAC Name: 1-ethyl-5-methyl-2-phenyl-1H-benzo[d]imidazole
InChIKey: LAPXJMHYUYXOQN-UHFFFAOYSA-N
SMILES: CC1=CC=C2N(CC)C(C3=CC=CC=C3)=NC2=C1
Biological Activity: Fc 11a-2, a benzimidazole compound, is an orally active and potent NLRP3 inflammasome inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS; HY-116282C)-induced murine experimental colitis[1][2][3].
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Fc 11a-2 | 99.75% | Fc 11a-2, a benzimidazole compound, is an orally active and potent NLRP3 inflammasome inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS; HY-116282C)-induced murine experimental colitis. | ||||||||||||||||||||
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- [1]. Liangkun Pan, et al. Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives and Analogs Targeting the NLRP3 Inflammasome. Molecules. 2017 Jan 30;22(2):213. [Content Brief]
- [2]. Wen Liu, et al. A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome. Biochem Pharmacol. 2013 May 15;85(10):1504-12. [Content Brief]
- [3]. Biswadeep Das, et al. Promise of the NLRP3 Inflammasome Inhibitors in In Vivo Disease Models. Molecules. 2021 Aug 18;26(16):4996. [Content Brief]
Keywords
