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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
174 Results for "
liver function
" in MedChemExpress (MCE) Product Catalog:
Products (174)
174 Results for "liver function" in MCE Product Catalog:
Cat. No.: HY-167681
CAS No.: 68020-77-9
Synonyms: Ro 12-4713
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Carprazidil (Ro 12-4713) is a potent vasodilator with activity in suppressing severe hypertension and mild heart failure. The use of carprazidil may lead to sodium retention and increased heart rate, requiring increased doses of diuretics or beta-blockers in some cases. Carprazidil and mecycline may both cause hirsutism, limiting their long-term use in women. Carprazidil did not cause adverse side effects on hematological parameters, liver, or kidney function .
Cat. No.: HY-P11626
CAS No.: 67943-21-9
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Cat. No.: HY-D3104
CAS No.: 2767443-23-0
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ERNT is a fluorescent probe for monitoring endoplasmic reticulum (ER) polarity and detecting endoplasmic reticulum stress (ERS) during the progression of dynamic liver injury. ERNT functions based on a donor-π-acceptor (D-π-A) structure with an intramolecular charge transfer (ICT) effect. ERNT has multiple excitation/emission pairs: for in vitro cell imaging, the green channel has Ex/Em = 488/500-550 nm, and the red channel has Ex/Em = 488/570-620 nm; for in vivo liver imaging, Ex/Em = 520/620 nm; for solvent optical tests, Ex = 470 nm, with the maximum emission peak at 548 nm in low-polarity toluene and 668 nm in high-polarity DMSO. ERNT can evaluate the efficacy of hepatoprotective interventions by detecting changes in ER polarity, and also exhibits excellent photostability and low cytotoxicity .
Cat. No.: HY-P992356
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Cat. No.: HY-L155
545 compounds
Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity.
MCE contains 545 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.
Cat. No.: HY-L224
2,478 compounds
Diarrhea is a disease symptom, and the pathophysiologic basis of diarrhea is a disturbance in intestinal water and electrolyte balance, which may be due to increased secretion of osmotically active electrolytes (secretory diarrhea) or increased intake of osmotically active substances (osmotic diarrhea). Food poisoning, pathogenic bacterial infections, and intestinal-related diseases can all contribute to the development of diarrhea. Traditional Chinese Medicine (TCM) considers diarrhea to be a symptom of an imbalance in the body's systems, particularly related to the functions of the spleen and stomach. Spleen qi deficiency, dampness-heat, liver and spleen disharmony are closely related to diarrhea. Many types of Chinese herbs regulate the function of diarrhea, such as: Dysosmae Verspiellis Rhixoma Et Radix, Ginkgo Semen, Forsythiae Fructus, and Campsis Flos.
MCE can provide 2,478 active monomers that can be obtained from TCM herbs with diarrhea-regulating functions, which can be applied to drug development and disease mechanism research.
Cat. No.: HY-50876A
CAS No.: 2727965-45-7
Synonyms: FK866 hydrochloride; APO866 hydrochloride
Daporinad (FK866) hydrochloride is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a Ki value of 0.3 nM. Daporinad hydrochloride depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad hydrochloride causes the depletion of the endoplasmic reticulum Ca²⁺ pool, ultimately weakening the mitogen-induced Ca²⁺ signal and the activation and function of T cells. Daporinad hydrochloride induces cell cycle arrest and apoptosis, and inhibits cell proliferation. Daporinad hydrochloride can be used for the study of myeloma, liver cancer, and immunosuppression .
Cat. No.: HY-181709
Synonyms: TG062
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TPM003 (TG062) is a triple agonist of GLP-1R, GIPR and GCGR, with EC50 values of 33.9, 12.5 and 92.9 pM, respectively. TPM003 suppresses appetite, regulates blood glucose, enhances insulin sensitivity, reduces gastrointestinal intolerance, promotes hepatic lipid mobilization and increases energy expenditure. TPM003 induces weight loss, improves metabolic parameters, reverses hepatic steatosis and optimizes liver function markers. TPM003 is applicable for research on obesity and non-alcoholic steatohepatitis .
Cat. No.: HY-P992007
Synonyms: RN909
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Cat. No.: HY-181604
CAS No.: 3047410-41-0
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MDH2-IN-2 is an orally active MDH2 inhibitor with an IC50 of 5.9 μM. MDH2-IN-2 reduces the levels of senescence markers and senescence-associated secretory phenotype (SASP) factors in mammalian cell models. MDH2-IN-2 extends the lifespan and improves the healthspan of Caenorhabditis elegans. MDH2-IN-2 alleviates tissue senescence in aged mice, inhibits SASP factors, and restores liver and kidney functions. MDH2-IN-2 is applicable for senescence-related research .
Cat. No.: HY-184381
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MAO-B-IN-61 is an orally active, brain-penetrant, highly selective, mixed-type reversible MAO-B inhibitor (IC50 = 14 nM, SI for MAO-A > 2857). MAO-B-IN-61 exhibits no significant cytotoxicity across various human cell lines and demonstrates good metabolic stability in rat and human liver microsomes. In an MPTP (HY-W114750)-induced rat model of Parkinson's disease, MAO-B-IN-61 exhibits significantly improving motor function and positioning itself as a promising candidate for Parkinson's disease research .
Cat. No.: HY-N7521
CAS No.: 37064-31-6
Synonyms: Procyanidine C2
Cat. No.: HY-178362
CAS No.: 3085155-69-4
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CAII/VII-IN-1 is an orally active hCA II (KI = 12.3 nM), and hCA VII (KI = 22.6 nM) inhibitor, showing no significant activity against hCA I. CAII/VII-IN-1 shows excellent neuroprotective activity in vivo Pilocarpine (HY-B0726A)-induced seizure model. CAII/VII-IN-1 can upregulate KCC2 and inhibit mTOR, exerting neuroprotective effects. CAII/VII-IN-1 does not show any significant neurotoxic effects or alterations in liver and kidney function. CAII/VII-IN-1 can be used for the study of epilepsy .
Cat. No.: HY-183878
CAS No.: 71431-46-4
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Zincov is an orally active hydroxamic acid derivative and bacterial metalloproteinase inhibitor. Zincov blocks chloride ion binding by binding to the active site of thermolysin, thereby inhibiting the hydrolysis and blood coagulation reactions catalyzed by this enzyme. Meanwhile, Zincov attenuates cytotoxicity, prevents protein degradation and ZO-1 rearrangement without affecting the functions of other common proteases. Zincov exhibits blood glucose-regulating and antioxidant activities; it reduces blood glucose levels and increases liver dry weight in diabetic rats, but elevates blood glucose levels in normal rats. Zincov is widely used in studies related to cholera and diabetes .
Cat. No.: HY-N0120
CAS No.: 65914-17-2
Synonyms: (E/Z)-Piceid
Category:
Stilbenes Polygonaceae Reynoutria japonica Houtt. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-W795967
CAS No.: 108605-69-2
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Cat. No.: HY-L265
558 compounds
Cholesterol is a crucial lipid that maintains cell membrane structure, serves as a precursor for the synthesis of steroid hormones and bile acids, and plays an important role in cell signal transduction and membrane function regulation. Intracellular cholesterol levels are precisely controlled by multiple processes, including synthesis, uptake, transport, esterification, storage, and efflux. Dysregulation of cholesterol metabolism is closely associated with diseases such as atherosclerosis, fatty liver disease, metabolic syndrome, and various cancers.
The Cholesterol Metabolism Compound Library contains 558 compounds and focuses on cholesterol metabolism and homeostatic regulation. It provides an efficient tool for mechanistic studies of cholesterol metabolism and for drug discovery in metabolism‑related diseases.
Cat. No.: HY-W017960
CAS No.: 1149-23-1
Synonyms: Et-HE; 1,4-DHP
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Diludine (BNP-7787) is an orally effective feed additive. Diludine reduces the activity of G6PD and increases the level of superoxide dismutase (SOD). Diludine reduces the mutagenic effect of environmental pollutants, protects parental reproductive systems and improves offspring quality. Diludine is mainly applied during the transition period of dairy cows to increase milk yield and milk fat content, and improve health status during parturition. Diludine can be used in animal feeding research .
Cat. No.: HY-145581B
CAS No.: 1933460-18-4
Synonyms: (rac)-AZD4831
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(rac)-Mitiperstat ((rac)-AZD4831) is the racemic form of Mitiperstat (HY-145581). Mitiperstat (AZD4831) is an effective oral inhibitor of myeloperoxidase (MPO). Mitiperstat inhibits MPO and thyroid peroxidase (TPO) with IC50s of 1.5 nM and 0.69 μM. Mitiperstat exhibits a weak inhibitory activity against CYP3A4 with an IC50 of 6 μM. Mitiperstat can reduce inflammation and improve microvascular function, and it can be used in studies related to heart failure, preserved or mildly reduced ejection fraction, non-alcoholic fatty liver disease, and chronic obstructive pulmonary disease .
Cat. No.: HY-159709
CAS No.: 2765519-47-7
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VL-422 is an ionizable cationic lipid. VL-422 delivers CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA to enable in vitro and in vivo gene editing. LNPs containing VL-422 loaded with Cas9 mRNA and sgRNA targeting the ANGPTL3 gene induce the deletion of premature stop codons within the ANGPTL3 gene in the liver of cynomolgus monkeys. Loss-of-function of ANGPTL3 leads to decreased levels of LDL, HDL and cholesterol in plasma. The VL-422 delivery system can be used for the research of gene editing strategies targeting lipid metabolism diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
