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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
159 Results for "
HTT,brain atrophy
" in MedChemExpress (MCE) Product Catalog:
Products (159)
159 Results for "HTT,brain atrophy" in MCE Product Catalog:
Cat. No.: HY-133970S1
CAS No.: 122241-86-5
Research Areas:
5α-Cholestane-d2 is the deuterated-labeled 5α-Cholestane (HY-133970). 5α-Cholestane is a steroidal hydrocarbon and fecal stanol, and is used as an internal standard for gas chromatographic sterol analysis. 5α-Cholestane is the parent steroidal skeleton of polyhydroxylated brassinosteroids of plant origin. It is used as an internal standard for GC-FID and GC-MS analysis of fecal sterols in urine and sludge samples. 5α-Cholestane can be used in studies of age- or disease-related skeletal muscle atrophy .
Cat. No.: HY-137557
CAS No.: 1565797-16-1
Synonyms: APN1607; PM-PBB3
Target:
Research Areas:
Florzolotau (APN1607) is a positron emission tomography (PET) ligand that can be used for the detection of Alzheimer's disease (AD) and other tau proteinopathies. Its binding sites are located in the β-sheet of paired helical filaments (PHFs) and straight filaments (SFs) of tau protein, as well as in the C-shaped cavity of SFs. In addition, APN-1607 binds to intraneuronal inclusions in Alzheimer's disease (AD), primary age-related tauopathy (PART) and posterior cortical atrophy (PCA). Florzolotau shows promise for PET imaging studies of neurological disorders, particularly tau proteinopathies .
Cat. No.: HY-182385
CAS No.: 1628945-93-6
Target:
Research Areas:
BPN-14136 is an orally effective retinol-binding protein 4 (RBP4) inhibitor. BPN-14136 inhibits the binding of retinol to RBP4 with an IC50 of 12.8 nM. BPN-14136 inhibits retinol-dependent RBP4-transthyretin interaction (IC50 = 43.6 nM) and reduces circulating plasma RBP4 levels in vivo. BPN-14136 decreases the formation of cytotoxic bisretinoids in retinal pigment epithelial cells. BPN-14136 can be used for the research of atrophic age-related macular degeneration and Stargardt disease .
Cat. No.: HY-123439
CAS No.: 249289-10-9
Target:
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FTY720-C2 is a derivative of FTY72 (HY-12005). FTY720-C2 promotes the expression of brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) in multiple system atrophy (MSA) models, without causing immunosuppression. FTY720-C2 improves motor dysfunction and reduces the levels of insoluble alpha-synuclein (αSyn) in MSA mouse models. FTY720-C2 is blood-brain barrier penetrate .
Cat. No.: HY-133970R
CAS No.: 481-21-0
Research Areas:
5α-Cholestane (Standard) is the analytical standard of 5α-Cholestane (HY-133970). This product is intended for research and analytical applications. 5α-Cholestane is a steroidal hydrocarbon and fecal stanol, and is used as an internal standard for gas chromatographic sterol analysis. 5α-Cholestane is the parent steroidal skeleton of polyhydroxylated brassinosteroids of plant origin. It is used as an internal standard for GC-FID and GC-MS analysis of fecal sterols in urine and sludge samples. 5α-Cholestane can be used in studies of age- or disease-related skeletal muscle atrophy .
Cat. No.: HY-151547S
Cat. No.: HY-19299
CAS No.: 245329-99-1
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology
CI-1018 is an orally active selective PDE-4 inhibitor, with IC50 values of 1.1 μM, 35.8 μM, and 73.4 μM against hPDE-4, canine PDE-4, and guinea pig PDE-4, respectively. CI-1018 induces iNOS expression and Apoptosis. CI-1018 induces vascular injury, medial necrosis, hemorrhage, edema, thymic atrophy, ketonuria, and weight loss. CI-1018 can be used in research related to asthma, vasculitis, and mesenteric vasculitis/arteriopathy .
Target:
Pirlindole is an orally active, selective and reversible MAO-A inhibitor with an IC50 value of 250 nM. Pirlindole inhibits genomic replication of Enterovirus species B and D, and exhibits moderate activity against enterovirus species A. Pirlindole inhibits MAO-A-mediated monoamine metabolism, promotes adult hippocampal neurogenesis, rescues stress-induced dendritic atrophy of hippocampal granule neurons, reverses behavioral effects associated with chronic mild stress, and also possesses anticonvulsant, analgesic, local anesthetic, hypotensive, antiplatelet aggregation and antispasmodic activities. Pirlindole shows no detectable mutagenic, clastogenic or carcinogenic properties. Pirlindole can be used in research related to depression and enterovirus infections .
Cat. No.: HY-100679A
CAS No.: 207572-66-5
Target:
Pirlindole mesylate is an orally active, selective and reversible MAO-A inhibitor with an IC50 value of 250 nM. Pirlindole mesylate inhibits genomic replication of Enterovirus species B and D, and exhibits moderate activity against enterovirus species A. Pirlindole mesylate inhibits MAO-A-mediated monoamine metabolism, promotes adult hippocampal neurogenesis, rescues stress-induced dendritic atrophy of hippocampal granule neurons, reverses behavioral effects associated with chronic mild stress, and also possesses anticonvulsant, analgesic, local anesthetic, hypotensive, antiplatelet aggregation and antispasmodic activities. Pirlindole mesylate shows no detectable mutagenic, clastogenic or carcinogenic properties. Pirlindole mesylate can be used in research related to depression and enterovirus infections .
Cat. No.: HY-111520R
CAS No.: 1562333-92-9
Target:
Research Areas:
NVS-SM2 (Standard) is the analytical standard of NVS-SM2 (HY-111520). This product is intended for research and analytical applications. NVS-SM2 is a potent, orally active and brain-penetrant SMN2 splicing enhancer with an EC50 of 2 nM for SMN. NVS-SM2 enhances U1-pre-mRNA association. NVS-SM2 promotes exon 7 inclusion and restores normal survival motor neuron (SMN) protein expression. NVS-SM2 can be used for spinal muscular atrophy (SMA) research .
Cat. No.: HY-125172
CAS No.: 300670-16-0
Synonyms: Polyglutamine Aggregation inhibitor III
Target:
Research Areas:
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s=25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.
Synonyms: ASC-JM17; ALZ-003
Target:
Keap1-Nrf2 Androgen Receptor HSP Mitophagy Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy
Research Areas:
Rosolutamide (ASC-JM17) is an orally active Nrf1/Nrf2 activator. Rosolutamide activates Hsf1 pathways, upregulates proteasome subunits and antioxidant enzymes, induces proteasome complex structural rearrangement, and enhances ubiquitin-proteasome system-mediated degradation. Rosolutamide reduces mutant androgen receptor and ataxin-3 aggregates, restores mitochondrial function, attenuates reactive oxygen species (ROS) levels, induces apoptosis and ferroptosis, and inhibits cancer cell growth. Rosolutamide can be used for the research of spinal and bulbar muscular atrophy, Huntington’s disease, and temozolomide-resistant glioblastoma .
Cat. No.: HY-W279140
CAS No.: 16154-78-2
Synonyms: Pyrazidole hydrochloride; Pirazidole hydrochloride
Target:
Pirlindole hydrochloride is an orally active, selective and reversible MAO-A inhibitor with an IC50 value of 250 nM. Pirlindole hydrochloride inhibits genomic replication of Enterovirus species B and D, and exhibits moderate activity against enterovirus species A. Pirlindole hydrochloride inhibits MAO-A-mediated monoamine metabolism, promotes adult hippocampal neurogenesis, rescues stress-induced dendritic atrophy of hippocampal granule neurons, reverses behavioral effects associated with chronic mild stress, and also possesses anticonvulsant, analgesic, local anesthetic, hypotensive, antiplatelet aggregation and antispasmodic activities. Pirlindole hydrochloride shows no detectable mutagenic, clastogenic or carcinogenic properties. Pirlindole hydrochloride can be used in research related to depression and enterovirus infections .
Cat. No.: HY-104044A
CAS No.: 2086689-94-1
Synonyms: BGB-290 maleate
Target:
Research Areas:
Pamiparib maleate (BGB-290 maleate) is a highly potent and selective PARP inhibitor with neurotoxicity-inducing activity. Pamiparib maleate can effectively penetrate the blood-brain barrier and cause cerebral hemorrhage, brain atrophy, and movement disorders in zebrafish embryos exposed. Pamiparib maleate exposure downregulates the activities of acetylcholinesterase (AChE) and adenosine triphosphatase (ATPase) and leads to upregulation of oxidative stress, which triggers apoptosis and interferes with the expression of neurodevelopment-related genes. The use of pamiparib maleate is also accompanied by downregulation of the Notch signaling pathway, while activation of the Notch signaling pathway can partially rescue neurodevelopmental toxicity. Therefore, pamiparib maleate provides a reference for evaluating its potential neurotoxicity during embryonic development .
Cat. No.: HY-P991797
Target:
Research Areas:
Cat. No.: HY-137557A
Synonyms: (E/Z)-APN1607; (E/Z)-PM-PBB3
Target:
Research Areas:
(E/Z)-Florzolotau ((E/Z)-APN1607) is a mixed configuration or unspecified configuration of Florzolotau (HY-137557). Florzolotau (APN1607) is a positron emission tomography (PET) ligand that can be used for the detection of Alzheimer's disease (AD) and other tau proteinopathies. Its binding sites are located in the β-sheet of paired helical filaments (PHFs) and straight filaments (SFs) of tau protein, as well as in the C-shaped cavity of SFs. In addition, APN-1607 binds to intraneuronal inclusions in Alzheimer's disease (AD), primary age-related tauopathy (PART) and posterior cortical atrophy (PCA). Florzolotau shows promise for PET imaging studies of neurological disorders, particularly tau proteinopathies .
Cat. No.: HY-167152
CAS No.: 292039-20-4
Target:
Research Areas:
Cardiovascular Disease Infection Neurological Disease Cancer
Pirlindole lactate is an orally active, selective and reversible MAO-A inhibitor with an IC50 value of 250 nM. Pirlindole lactate inhibits genomic replication of Enterovirus species B and D, and exhibits moderate activity against enterovirus species A. Pirlindole lactate inhibits MAO-A-mediated monoamine metabolism, promotes adult hippocampal neurogenesis, rescues stress-induced dendritic atrophy of hippocampal granule neurons, reverses behavioral effects associated with chronic mild stress, and also possesses anticonvulsant, analgesic, local anesthetic, hypotensive, antiplatelet aggregation and antispasmodic activities. Pirlindole lactate shows no detectable mutagenic, clastogenic or carcinogenic properties. Pirlindole lactate can be used in research related to depression and enterovirus infections .
Cat. No.: HY-W275882
CAS No.: 13179-98-1
Target:
Research Areas:
1,6-Dimethoxyhexane is an aliphatic ether that serves as a PROTAC linker and fuel additive. 1,6-Dimethoxyhexane is an orally active testicular toxicant. It has no direct toxicity on its own, but exerts toxicity after oxidative metabolism by liver/testicular microsomes to produce 2-Methoxyacetic Acid (MAA). 1,6-Dimethoxyhexane induces apoptosis/necrosis of pachytene spermatocytes, downregulates the expression of HSP70.2, HSP60 and ERp60/PDI A3, and causes spermatogenic tubule degeneration, testicular/thymic atrophy, a sharp decline in epididymal sperm density, and other effects. 1,6-Dimethoxyhexane can be used in studies related to testicular toxicity .
Cat. No.: HY-100679R
CAS No.: 60762-57-4
Pirlindole (Standard) is the analytical standard of Pirlindole (HY-100679). This product is intended for research and analytical applications. Pirlindole is an orally active, selective and reversible MAO-A inhibitor with an IC50 value of 250 nM. Pirlindole inhibits genomic replication of Enterovirus species B and D, and exhibits moderate activity against enterovirus species A. Pirlindole inhibits MAO-A-mediated monoamine metabolism, promotes adult hippocampal neurogenesis, rescues stress-induced dendritic atrophy of hippocampal granule neurons, reverses behavioral effects associated with chronic mild stress, and also possesses anticonvulsant, analgesic, local anesthetic, hypotensive, antiplatelet aggregation and antispasmodic activities. Pirlindole shows no detectable mutagenic, clastogenic or carcinogenic properties. Pirlindole can be used in research related to depression and enterovirus infections .
Cat. No.: HY-100679S
CAS No.: 1801646-26-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
