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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1885 Results for "
Reactive
" in MedChemExpress (MCE) Product Catalog:
Products (1885)
1885 Results for "Reactive" in MCE Product Catalog:
Cat. No.: HY-105904
CAS No.: 54824-20-3
Research Areas:
Pinafide is an orally active anticancer agent. Pinafide binds to double-stranded DNA via intercalation, stabilizes the DNA-topoisomerase II complex, induces photo-induced DNA damage and ROS production, causes lysosomal and mitochondrial dysfunction, impairs DNA and RNA synthesis, and blocks cell growth. Pinafide binds to human serum albumin in vitro, undergoes biotransformation via reduction and acetylation in rats, and can cross the placental barrier of pregnant rats. Pinafide can be used in cancer-related research such as hepatocellular carcinoma .
Cat. No.: HY-156065
CAS No.: 2700303-28-0
Research Areas:
S217879 is an orally active and selective NRF2 activator. S217879 activates the NRF2 pathway by specifically disrupting the KEAP1 (Kd: 4.15 nM)-NRF2 interaction, and upregulates the antioxidant response. S217879 also ameliorates steatohepatitis and reduces the degree of liver fibrosis. S217879 can be used in the research of metabolic dysfunction-associated steatotic liver disease and nonalcoholic steatohepatitis .
Cat. No.: HY-169072
CAS No.: 3103327-20-1
Research Areas:
PROTAC MLKL Degrader-2 is an orally active and highly selective mixed lineage kinase domain-like pseudokinase (MLKL) PROTAC degrader with a DC50 of 0.012 μM. PROTAC MLKL Degrader-2 recruits the CRBN E3 ubiquitin ligase to form a ternary complex, leading to ubiquitination of MLKL and its degradation via a proteasome-dependent pathway. PROTAC MLKL Degrader-2 inhibits necroptosis, reduces ROS production, restores mitochondrial function, and ameliorates lysosomal dysfunction induced by necroptotic stimuli. PROTAC MLKL Degrader-2 degrades MLKL in xenograft mouse models. PROTAC MLKL Degrader-2 can be used in cancer-related research .
Cat. No.: HY-181598
CAS No.: 3057531-85-5
Research Areas:
GPX4 degrader-1 (Compound RS-1) is a hydrophobic tagging (HyT)-mediated GPX4 degrader (DC50: 8.9 nM in HT1080 cells) GPX4 degrader-1 induces GPX4 degradation. GPX4 degrader-1 induces Ferroptosis. GPX4 degrader-1 increases lipid ROS. GPX4 degrader-1 demonstrates potent antitumor efficacy in a murine mammary carcinoma model .
Cat. No.: HY-181656
Research Areas:
GPX4 degrader-2 is a GPX4 molecular glue degrader and ferroptosis inducer. GPX4 degrader-2 suppresses GPX4 enzyme activity, promotes ubiquitination-dependent proteasomal degradation of GPX4 protein. GPX4 degrader-2 indues ferroptosis, increases lipid ROS and MDA levels, suppresses glutathione levels in cancer cells. GPX4 degrader-2 inhibits cancer cells proliferation and colony formation. GPX4 degrader-2 can be used for the research of colorectal cancer .
Cat. No.: HY-184452
Research Areas:
BNNC is a Photomolecular glue . BNNC selectively releases (R)-CR8 (HY-18340) (a Cyclin K molecular glue) and BSS-Et in hypoxic tumor microenvironments, thereby triggering Cyclin K degradation dependent on the ubiquitin-proteasome pathway. BNNC generates ROS and singlet oxygen in hypoxic tumor cells under light irradiation. BNNC enhances DNA damage and Apoptosis through the combined effects of Cyclin K degradation and phototherapy. BNNC enhances the tumor selectivity of molecular glue via specific activation in hypoxic tumor microenvironments. BNNC can be used in breast cancer-related research .
Category:
Cat. No.: HY-N2180A
CAS No.: 25305-05-9
Synonyms: (±)-Eudesmine
Cat. No.: HY-N3741
CAS No.: 18296-45-2
Synonyms: Didrovaltratum
Cat. No.: HY-N6821
CAS No.: 129499-78-1
Target:
Research Areas:
2-O-α-D-Glucopyranosyl-L-ascorbic Acid is an orally active glucoside derivative of ascorbic acid. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid can be hydrolyzed by α-glucosidase to release ascorbic acid. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid inhibits melanin synthesis, prevents UV-induced cell damage, and promotes collagen synthesis in skin fibroblasts. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid also induces oxidative stress to inhibit tumor growth. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid can be used in research related to tumors, inflammation, and other conditions .
Cat. No.: HY-P11489
CAS No.: 252731-57-0
Research Areas:
Cat. No.: HY-P4111
CAS No.: 1318232-11-9
Target:
Research Areas:
Cat. No.: HY-W115789
CAS No.: 1344-09-8
Cat. No.: HY-W343900
CAS No.: 6912-67-0
Synonyms: DL-Hydroxyproline
Research Areas:
Hydroxyproline (DL-Hydroxyproline) is a non-essential amino acid and one of the main components of collagenous tissues. Hydroxyproline acts as a substrate for mitochondrial hydroxyproline oxidase to generate ROS. Hydroxyproline promotes the synthesis of glutathione, DNA, heme and proteins via conversion to Glycine (HY-Y0966). Hydroxyproline promotes the activation of caspase-9 and apoptosis in cancer cells treated with Doxorubicin . Hydroxyproline serves as a biochemical marker. Hydroxyproline is used in research related to various diseases including colon cancer, diabetes and arthritis .
Cat. No.: HY-181073
Target:
Research Areas:
Apoptosis/necroptosis inducer 1 is an orally active and brain-penetrant apoptosis and necroptosis inducer. Apoptosis/necroptosis inducer 1 induces mitochondria-dependent (intrinsic pathway) apoptosis. Apoptosis/necroptosis inducer 1 induces necroptosis by activating the TNF-α/NF-κB/MAPK signaling pathway. Apoptosis/necroptosis inducer 1 exhibits antiproliferative activity in glioblastoma cell lines and multiple solid tumor types. Apoptosis/necroptosis inducer 1 inhibits growth of orthotopic glioblastoma in animal models and improves survival rate. Apoptosis/necroptosis inducer 1 can be used for the research of glioblastoma .
Cat. No.: HY-182802
CAS No.: 3097756-33-4
Research Areas:
Ferroptosis inducer-15 is a ferroptosis inducer. Ferroptosis inducer-15 downregulates GPX4 expression, triggers lipid peroxidation via ROS accumulation, and disrupts mitochondrial membrane potential to drive ferroptosis. Ferroptosis inducer-15 increases splenic CD4 + T cell proportion, promotes CD8 + cytotoxic T cell tumor infiltration, and activates antitumor immune responses. Ferroptosis inducer-15 exerts antiproliferative activity against colorectal cancer cells and inhibits tumor growth in xenograft mice models without significant body weight loss. Ferroptosis inducer-15 can be used for the research of cancer, such as colorectal cancer .
Cat. No.: HY-183290
Research Areas:
Antileishmanial agent-41 (Compound 20k) is a selective Antileishmanial agent with a IC50 of 1.51 μg/mL against Leishmania donovani. Antileishmanial agent-41 increases ROS levels. Antileishmanial agent-41 can be used for the research of leishmaniasis .
Cat. No.: HY-183621
Research Areas:
Antileishmanial agent-43 is a 3,4,5‑trisubstituted isoxazole with selective antileishmanial activity. Antileishmanial agent-43 shows IC50 values of 12.7 μM against Leishmania amazonensis promastigotes and 0.96 μM against intracellular amastigotes. Antileishmanial agent-43 induces ROS elevation, oxidative stress and mitochondrial dysfunction, resulting in lipid peroxidation, mitochondrial depolarization and ATP imbalance. Antileishmanial agent-43 causes cell shrinkage, phosphatidylserine externalization, plasma membrane permeabilization, and promotes autophagy. Antileishmanial agent-43 can be used for the research of leishmaniasis .
Cat. No.: HY-183987
CAS No.: 859138-65-1
Research Areas:
ZINC000002107582 is a UVRAG binder. ZINC000002107582 induces Apoptosis, increases intracellular ROS levels, arrests the cell cycle at the S phase, and elevates the proportion of cells in the Sub G0 phase. ZINC000002107582 exhibits anticancer activity against breast cancer .
Cat. No.: HY-184308
CAS No.: 3123321-73-0
Target:
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Antifungal agent-165 is an antifungal agent with in vitro activity against Rhizoctonia solani. Antifungal agent-165 inhibits catalase (CAT) activity, drives intracellular ROS accumulation, and induces oxidative damage. Antifungal agent-165 disrupts fungal hyphal morphology, compromises cell membrane integrity, and triggers cellular content leakage in Rhizoctonia solani. Antifungal agent-165 can be used for the research of potato black scurf disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
