239 Results for "

Neutralizing

" in MedChemExpress (MCE) Product Catalog:
Products (239)

239 Results for "Neutralizing" in MCE Product Catalog:

Cat. No.: HY-P99906
CAS No.: 2414962-49-3
Synonyms: DKN-01; LY-2812176

Target:  

β-catenin Wnt

Research Areas:  

Cancer

Sirexatamab (DKN-01; LY-2812176) is a humanized IgG4 monoclonal antibody targeting DKK1, with Kd values of 3.3 pM and 20 pM for human and murine (mDKN-01) forms, respectively. Sirexatamab binds to DKK1 to neutralize its activity and reverse the inhibition of the canonical Wnt/β-catenin signaling pathway. Sirexatamab can be used in research related to cancers such as non-small cell lung cancer, endometrial cancer, and ovarian cancer .
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Cat. No.: HY-P990817

Target:  

Dengue Virus Flavivirus

Research Areas:  

Infection

Anti-West Nile/dengue virus E protein Antibody (E60) is mouse-derived IgG2a κ type antibody inhibitor, targeting to West Nile/dengue virus E protein. Anti-West Nile/dengue virus E protein Antibody (E60) can cross-neutralize West Nile virus (WNV) and dengue virus (DENV) envelope (E) protein. Anti-West Nile/dengue virus E protein Antibody (E60) can be used for the researches of WNV and DENV infection .
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Cat. No.: HY-P990837

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Anti-IL-4 Antibody (MP4-25D2) is a kind of rat IgG1 κ chimeric antibody inhibitor, targeting to human IL-4. Anti-IL-4 Antibody (MP4-25D2) can neutralize human IL-4 (interleukin-4). Anti-IL-4 Antibody (MP4-25D2) can be used for the inflammation and immunology .
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Cat. No.: HY-P990841

Target:  

Glycoprotein VI

Research Areas:  

Cancer

Anti-pan-Glypican Antibody (HS20) is a kind of human IgG1 κ human antibody, targeting to human pan-Glypican. Anti-pan-Glypican Antibody (HS20) can neutralize the heparan sulfate (HS) chains on GPC3 thereby disrupting the Wnt3a-GPC3 interactions leading to blockade of the Wnt3a/β-catenin signaling. Anti-pan-Glypican Antibody (HS20) can be used for the research of cancer, such as hepatocellular carcinoma (HCC) .
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Cat. No.: HY-P99127

Target:  

Integrin

Research Areas:  

Inflammation/Immunology

Anti-Mouse CD54 Antibody (YN1/1.7.4) is an anti-mouse CD54 IgG2b antibody inhibitor derived from host Rat. Anti-Mouse CD54 Antibody (YN1/1.7.4) can neutralize CD54 also known as Intercellular Adhesion Molecule-1 (ICAM-1). Anti-Mouse CD54 Antibody (YN1/1.7.4) can be used for the research of inflammation .
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Cat. No.: HY-P991674
CAS No.: 3033337-14-0
Synonyms: BJT-778

Target:  

HBV

Research Areas:  

Infection Inflammation/Immunology

Brelovitug (BJT-778) is a humanized IgG1 neutralizing monoclonal antibody targeting hepatitis B surface antigen (HBsAg). Brelovitug binds with high affinity to HBsAg purified from HBV serotypes ad and ay, with Kd values of 0.22 nM and 0.39 nM, respectively. Brelovitug binds with high affinity to HBsAg of HBV genotypes A, B, C and D, with IC50 values of 0.07, 0.02, 0.02 and 0.07 nM, respectively. Brelovitug can be used in research related to chronic hepatitis B and chronic hepatitis D .
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Cat. No.: HY-P992174

Target:  

RSV

Research Areas:  

Infection

ADI-14359 is an antibody that binds to RSV postF, with a KD value of 387 nM, and exhibits non-neutralizing activity. ADI-14359 binds to antigenic site I on RSV postF through interactions of its conserved CDR H3 motif, germline-encoded IGKV1-39 light chain residues and heavy chain residues, where the light chain mediates preferential binding to postF by conflicting with the rearranged preF region. ADI-14359 can be used in studies related to respiratory syncytial virus (RSV) infection .
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Cat. No.: HY-P99551
CAS No.: 1374419-41-6
Synonyms: KBSA301; AR-301

Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent. Recommend Isotope Control: Human IgG1 lambda1, Isotype Control (HY-P99992) .
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Cat. No.: HY-P99620
CAS No.: 1443004-15-6
Synonyms: CT-P22; CT120

Target:  

Influenza Virus

Research Areas:  

Infection

Firivumab (CT-P22; CT120) is a human IgG1 monoclonal influenza A virus hemagglutinin (Anti-IAV HA) antibody. Firivumab is capable of neutralizing H1N1, H5N1, H6N1, H6N2, H8N4, H8N8, H9N2 and H12N7. Firivumab shows protection against H1N1 virus in mice .
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Cat. No.: HY-105005
CAS No.: 927685-43-6
Purity:  98.92%
Synonyms: AAD-2004
Crisdesalazine (AAD-2004) is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Crisdesalazine acts as a potent free radical scavenger that directly neutralizes reactive oxygen species (ROS) including hydrogen peroxide, exerting neuroprotective effects against apoptosis and axonal damage. Crisdesalazine inhibits PGE2 production, mediates inflammatory responses, and promotes the conversion of macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype. Crisdesalazine is applicable to neuroprotection research in multiple sclerosis and spinal cord injury .
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Cat. No.: HY-108628R
CAS No.: 251356-45-3
Research Areas:  

Cancer

SU16f (Standard) is the analytical standard of SU16f (HY-108628). This product is intended for research and analytical applications. SU16f is a potent and selective PDGFRβ inhibitor with IC50s of 10 nM, 140 nM, 2.29 μM for PDGFRβ, VEGF-R2, FGF-R1, respectively . Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs (gastric cancer-derived mesenchymal stem cells) conditioned medium in gastric cancer cell proliferation and migration .
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Cat. No.: HY-126360R
CAS No.: 15646-46-5
Oxazolone (Standard) is the analytical standard of Oxazolone (HY-126360). This product is intended for research and analytical applications. Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins .
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Cat. No.: HY-180129
CAS No.: 308293-08-5
Target:  

SARS-CoV

Research Areas:  

Infection

SARS-CoV-2-IN-120 (Compound S22) is a SARS-CoV-2-specific entry inhibitor. SARS-CoV-2-IN-120 binds and trimerizes within the apex cavity of the SARS2 spike trimer. SARS-CoV-2-IN-120 blocks RBD-ACE2 interaction. SARS-CoV-2-IN-120 neutralizes BA.2 and subsequent Omicron variants. SARS-CoV-2-IN-120 inhibits SARS-CoV-2 replication in mice .
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Cat. No.: HY-B0215R
CAS No.: 616-91-1
Synonyms: N-Acetylcysteine (Standard); N-Acetyl-L-cysteine (Standard); NAC (Standard)
Acetylcysteine (Standard) is the analytical standard of Acetylcysteine. This product is intended for research and analytical applications. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor . Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases . Acetylcysteine induces cell apoptosis . Acetylcysteine also has anti-influenza virus activities . In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .
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Cat. No.: HY-B0215S
CAS No.: 131685-11-5
Synonyms: N-Acetylcysteine-d3; N-Acetyl-L-cysteine-d3; NAC-d3
Acetylcysteine-d3 is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .
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Cat. No.: HY-P5552
CAS No.: 709611-59-6
Target:  

Bacterial Fungal

Research Areas:  

Infection

Melimine is an antimicrobial peptide with broad-spectrum antimicrobial activity against Gram-negative/Gram-positive bacteria, fungi and protozoa. Melimine neutralizes endotoxin activity by interacting with the phosphate groups of lipid A, depolarizes and permeabilizes the cytoplasmic membrane of *Pseudomonas aeruginosa*, and induces bacterial lysis. Melimine exerts additive antiviral effects against H1N1 and MHV-1 when used in combination with RK610. Melimine retains its antimicrobial activity when conjugated to polymer and titanium surfaces. Melimine can be used in infection-related research .
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Cat. No.: HY-P5552A
Target:  

Bacterial Fungal

Research Areas:  

Infection

Melimine acetate is an antimicrobial peptide with broad-spectrum antimicrobial activity against Gram-negative/Gram-positive bacteria, fungi and protozoa. Melimine acetate neutralizes endotoxin activity by interacting with the phosphate groups of lipid A, depolarizes and permeabilizes the cytoplasmic membrane of *Pseudomonas aeruginosa*, and induces bacterial lysis. Melimine acetate exerts additive antiviral effects against H1N1 and MHV-1 when used in combination with RK610. Melimine acetate retains its antimicrobial activity when conjugated to polymer and titanium surfaces. Melimine acetate can be used in infection-related research .
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Cat. No.: HY-P990205
Anti-Mouse/Human KLRG-1 Antibody (2F1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse/human KLRG-1. Anti-Mouse/Human KLRG-1 Antibody (2F1) neutralizes KLRG1. Anti-Mouse/Human KLRG-1 Antibody (2F1) reduces T-cell receptor signals and regulatory T-cell accumulation. Anti-Mouse/Human KLRG-1 Antibody (2F1) can be used for the researches of immunology .
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Cat. No.: HY-P990226

Target:  

Interleukin Related

Research Areas:  

Infection Inflammation/Immunology

Anti-Mouse IL-12 p35 Antibody (C18.2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-12 p35. Anti-Mouse IL-12 p35 Antibody (C18.2) can neutralize IL-12. Anti-Mouse IL-12 p35 Antibody (C18.2) can be used for the researches of infection, inflammation and immunology, such as airway inflammation and F. tularensis infection .
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Cat. No.: HY-P990227
Anti-Mouse IL-12 Antibody (R1-5D9) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse IL-12. Anti-Mouse IL-12 Antibody (R1-5D9) can neutralize IL-12. Anti-Mouse IL-12 Antibody (R1-5D9) can be used for the researches of infection, inflammation and immunology, such as Leishmania infection and skin inflammation .
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