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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
61 Results for "
17 beta-hydroxysteroid dehydrogenase
" in MedChemExpress (MCE) Product Catalog:
Products (61)
61 Results for "17 beta-hydroxysteroid dehydrogenase" in MCE Product Catalog:
3
Category:
Monophenols Disease markers Metabolic Disease Endocrine diseases Phenols Nervous System Disorder Endogenous metabolite Disease Research Fields Steroids
Target:
2
Category:
Human Gut Microbiota Metabolites Immune System Disorder Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology Steroids
Target:
1
1 Cited Publications
Synonyms: 4-Androsten-11β-ol-3,17-dione
Target:
1
1 Cited Publications
Cat. No.: HY-P7604
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AKR1C3; Aldo-Keto Reductase Family 1, Member C3 (3-Alpha hydroxysteroid dehydrogenase, Type II), Isoform CRA_a; Prev. HSD17B5; Trans-1,2-Dihydrobenzene-1,2-Diol dehydrogenase; PGFS; Type IIb 3-Alpha hydroxysteroid dehydrogenase; Prostaglandin F Synthase; 3-Alpha-hydroxysteroid dehydrogenase Type 2; KIAA0119; 17-beta-hydroxysteroid dehydrogenase Type 5; HAKRB; hydroxysteroid (17-beta) dehydrogenase 5; DDX; Dihydrodiol dehydrogenase Type I; 3-Alpha hydroxysteroid dehydrogenase, Type II; Indanol dehydrogenase; Testosterone 17-beta-dehydrogenase 5; 3-Alpha-HSD Type 2; Chlordecone Reductase Homolog HAKRb; 17-beta-HSD 5; Dihydrodiol dehydrogenase X; HluPGFS; Dihydrodiol dehydrogenase 3; HAKRe; 3-Alpha-HSD Type II, Brain; DD-3; HA1753; DDH1; DD3; Aldo-Keto Reductase Family 1 Member C3; Aldo-Keto Reductase Family 1, Member C3 (3-Alpha hydroxysteroid dehydrogenase, Type II)
Species:
Human
Source:
HEK293
Cat. No.: HY-124529
CAS No.: 37116-80-6
Category:
Human Gut Microbiota Metabolites other families Conocephalum conicum (L.) Dumort. Phenols Polyphenols Plants Endogenous metabolite
Target:
Synonyms: 4-Androsten-11β-ol-3,17-dione-d7
Cat. No.: HY-18173
CAS No.: 1048668-70-7
Target:
Research Areas:
AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3 .
Cat. No.: HY-160618
CAS No.: 1834601-37-4
Target:
Research Areas:
11β-HSD2-IN-2 (compound 3) is a selective inhibitor for 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) with an IC50 of 300 nM .
Cat. No.: HY-W741510
CAS No.: 1882-82-2
Synonyms: 21-Desoxycortisone; NSC 38722
Target:
Research Areas:
21-Deoxy Cortisone (21-Desoxycortisone; NSC 38722) is a corticosteroid metabolite of 11-ketoprogesterone. It is formed from 11-ketoprogesterone by the cytochrome P450 (CYP) isozyme CYP17A1, but can also be produced by oxidation of 21-deoxycortisone (HY-113405) by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Congenital adrenal hyperplasia is an inborn error of metabolism characterized by a deficiency of 21-hydroxylase, and 21-Deoxy Cortisone levels are elevated in patients with congenital adrenal hyperplasia.
Cat. No.: HY-W002734
CAS No.: 87199-18-6
Synonyms: 3-Hydroxybenzeneboronic acid
Target:
Research Areas:
(3-Hydroxyphenyl)boronic acid (3-Hydroxybenzeneboronic acid) is a drug intermediate that can be used for the synthesis of 17β-hydroxysteroid dehydrogenase type 1 inhibitors .
TC HSD 21 is a selective inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) against related 17β-HSD isozymes, with an IC50 of 14 nM in HeLa cells. TC HSD 21 can be used in the research of prostate cancer .
17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) with blood-brain permeability. 17β-HSD10-IN-1 doesn't result additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects .
Cat. No.: HY-177634
CAS No.: 2409783-34-0
Target:
Research Areas:
Gatuzosiran, a siRNA,is a 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) synthesis reducer. It is used for the study of fatty liver disease.
Cat. No.: HY-106447
CAS No.: 72141-57-2
Target:
Research Areas:
Losulazine is an orally active antihypertensive agent. Losulazine modulates acid phosphatase, 3β-hydroxysteroid dehydrogenase, and 17β-hydroxysteroid dehydrogenase activity. Losulazine can be used for the research of hypertension .
Cat. No.: HY-113263R
CAS No.: 387-79-1
Synonyms: 17-OHP5 (Standard)
Research Areas:
17a-Hydroxypregnenolone (Standard) is the analytical standard of 17a-Hydroxypregnenolone. This product is intended for research and analytical applications. 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .
Synonyms: 17-OHP5-d3
Cat. No.: HY-177634A
Target:
Research Areas:
Gatuzosiran sodium, a siRNA,is a 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) synthesis reducer. It is used for the study of fatty liver disease.
Cat. No.: HY-W016604
CAS No.: 2589-71-1
Synonyms: 4-Pentanoylphenol; 4-Valerylphenol
4'-Hydroxyvalerophenone (Compound 4) is an inhibitor of 17β-hydroxysteroid dehydrogenase (17β-HSD) with an IC50 of 60.52 μM .
Cat. No.: HY-129433
CAS No.: 1318265-18-7
Target:
Research Areas:
17β-HSD1-IN-2 (PBRM) is a non-estrogenic and steroidal covalent irreversible inhibitor of 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) (Ki=368 nM). 17β-HSD1-IN-2 can be used for the research of estrogen-dependent disorders .
Adamantanone (2-Adamantone; 2-Oxoadamantane) serves as a substrate for some alcohol dehydrogenases and also acts as a probe for characterizing substrate-binding pockets. Adamantanone can be reduced by 3α-hydroxysteroid dehydrogenase and 3β-17β-hydroxysteroid dehydrogenase derived from Pseudomonas testosteroni, and it can fit into the conformationally flexible substrate-binding pockets of these enzymes that undergo substrate-induced fit .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
