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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
5-Aminothalidomide
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "5-Aminothalidomide" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-P2336A
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1 Cited Publications
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Natural Products Animals Marine natural products Other marine organisms Disease Research Fields Cancer
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Cat. No.: HY-P4070
CAS No.: 1188379-43-2
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Cat. No.: HY-W023573
CAS No.: 191732-76-0
Cat. No.: HY-P5362
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GBD-9 is a degrader based on the E3 ubiquitin ligase CRBN that targets BTK and the G1 to S phase transition protein GSPT1. GBD-9 has both PROTAC and molecular glue properties by inducing ubiquitination and proteasomal degradation of target proteins. GBD-9 can efficiently degrade wild-type and mutant BTK (such as C481S mutation) and GSPT1. GBD-9 significantly inhibits tumor cell proliferation by inducing G1 phase arrest in cancer cells, downregulating anti-apoptotic proteins (BCL-2, MCL-1) and activating Caspase-3 to induce apoptosis. GBD-9 is mainly used in the research of hematological tumors such as diffuse large B-cell lymphoma (DLBCL) and acute myeloid leukemia (AML) .
GBD-9 is composed of E3 ubiquitin ligase ligand (pink part) 5-Aminothalidomide (HY-W023573), target protein ligand (blue part) Btk Inhibitor: IBT6A (HY-13036A), and PROTAC linker (black part) Nonanoic acid (HY-N7057).
GBD-9 is composed of E3 ubiquitin ligase ligand (pink part) 5-Aminothalidomide (HY-W023573), target protein ligand (blue part) Btk Inhibitor: IBT6A (HY-13036A), and PROTAC linker (black part) Nonanoic acid (HY-N7057).
Cat. No.: HY-P10341
CAS No.: 1345835-12-2
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Cat. No.: HY-174869
CAS No.: 2412056-40-5
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Pomalidomide-5-C7-NH2 is an E3 ligase ligand-linker conjugate that incorporates the 5-Aminothalidomide (HY-W023573) based CRBN ligand (HY-103596) and linker. Pomalidomide-5-C7-NH2 can be used for synthesis of PROTAC BT-O2C (HY-174866) .
Cat. No.: HY-163929
CAS No.: 2924858-26-2
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5-Aminothalidomide-cyclohexane is an E3 ligase ligand-linker conjugate.
Cat. No.: HY-168553
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3-Hydroxyazetidine-Cyclohexanol-5-Aminothalidomide is a E3 ligase ligand-linker conjugate that can be used in the synthesis of ALK PROTAC (HY-168551) .
Cat. No.: HY-168277
CAS No.: 3053782-32-1
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5-Aminothalidomide-C9-Boc is a E3 ligase ligand-linker conjugate, used for the synthesis of PROTAC TRIB2 degrader-1 (HY-168274) .
Cat. No.: HY-P11004
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Cat. No.: HY-P10472
CAS No.: 134457-28-6
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Cat. No.: HY-P4757
CAS No.: 108081-77-2
Cat. No.: HY-P11243
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Cat. No.: HY-P2434
CAS No.: 846569-60-6
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Cat. No.: HY-P5362A
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Cat. No.: HY-105168
CAS No.: 157380-72-8
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Cat. No.: HY-P2075
CAS No.: 126784-34-7
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Cat. No.: HY-P10876
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
