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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
ACK1
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "ACK1" in MCE Product Catalog:
4
4 Cited Publications
AIM-100 is a potent and selective Ack1 inhibitor with an IC50 of 21.58 nM. AIM-100 also inhibits Tyr 267 phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect [1] .
2
2 Cited Publications
GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-Abl WT and Bcr-Abl T315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies [1] .
1
1 Cited Publications
Forschungsgebiete:
KRCA-0008 is a selective ALK/Ack1 inhibitor with IC50s of 12 and 4 nM for ALK and Ack1, respectively. KRCA-0008 can be used for the research of cancer [1] .
Target:
Ack1 JAK Anaplastic lymphoma kinase (ALK) Src Bcr-Abl Checkpoint Kinase (Chk) FGFR ROS Kinase
Forschungsgebiete:
(R)-9b is an ATP-competitive kinase inhibitor. (R)-9b binds to the ATP-binding site of ACK1/TNK2, inhibiting their kinase activity and autophosphorylation, with a human IC50 of 56 nM. (R)-9b also inhibits JAK2, Tyk2, ALK, c-Src, ABL1, CHK1, FGFR1, LCK, and ROS/ROS1. (R)-9b can be used for research on prostate cancer [1].
Synonyms: ACK1-B19
Target:
Forschungsgebiete:
XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively.
Art. -Nr.: HY-149989
CAS. Nr.: 2924415-92-7
Ack1 inhibitor 1 is a potent, selective, and orally active inhibitor of ACK1 kinase with an IC50 value of 2.1 nM. Ack1 inhibitor 1 inhibits the phosphorylation of ACK1 and activation of downstream AKT. Ack1 inhibitor 1 has anti-tumor activity [1].
Art. -Nr.: HY-160635
CAS. Nr.: 1196392-26-3
Ack1 inhibitor 2 (Example 259) is an Ack1 inhibitor (IC50: 0.46 μM) [1].
Art. -Nr.: HY-162254
CAS. Nr.: 3032642-29-5
EGFR T790M/L858R/ACK1-IN-1 is a dual inhibitor of EGFR T790M/L858R and ACK1. IC50 values are 23 and 263 nM, respectively. EGFR T790M/L858R/ACK1-IN-1 can inhibit cell proliferation and has antitumor activity [1].
Art. -Nr.: HY-E70868
Thirty-eight-negative kinase-1 (TNK1) is a member of the ACK family of NRTKs, which includes only two human kinases, TNK1 and TNK2 (also called ACK1). TNK1 Recombinant Human Active Protein Kinase is a recombinant TNK1 protein that can be used to study TNK1-related functions [1].
Art. -Nr.: HY-P75542
Reinheit: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: TNK2; ACK; Tyrosine Kinase Non Receptor 2; Activated Cdc42-Associated Kinase 1; ACK1; ACK-1; Tyrosine Kinase Non-Receptor Protein 2; Non-Specific Protein-Tyrosine Kinase; Activated CDC42 Kinase 1; Tyrosine Kinase, Non-Receptor, 2; P21cdc42Hs; Activated P2
Species:
Human
Source:
Sf9 insect cells
Art. -Nr.: HY-RS14838
Target:
Forschungsgebiete:
TNK2 Human Pre-designed siRNA Set A contains three designed siRNAs for TNK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-10943R
CAS. Nr.: 839706-07-9
Target:
Forschungsgebiete:
GNF-7 (Standard) is the analytical standard of GNF-7 (HY-10943). This product is intended for research and analytical applications. GNF-7 is a multiKinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-AblWT and Bcr-AblT315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 Kinase 1) and GCK (germinal center Kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies [1] .
Art. -Nr.: HY-RS16928
Target:
Forschungsgebiete:
Tnk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
