7 Results for "

AP2A2

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "AP2A2" in MCE Product Catalog:

2
TAT-GluA2 3Y
TAT-GluA2 3Y
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2 Cited Publications
Cat. No.: HY-P2259
CAS No.: 1404188-93-7
Target:  

iGluR HIV Integrase Adenosine Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease

TAT-GluA2 3Y is a blood-brain barrier-permeable AMPA receptor inhibitory peptide that crosses cell membranes via the HIV-1 TAT protein domain. TAT-GluA2 3Y blocks the endocytosis of AMPA receptors, including the internalization of GluA1/GluA2 subunits, by disrupting interactions with the AP2, Brag2 and Syt3-GluA2 complexes, while also inhibiting long-term depression. TAT-GluA2 3Y blocks hypoxia-mediated AMPAR internalization, alleviates A1R-induced persistent synaptic inhibition, and reduces cerebral ischemic volume, neurological deficits and spatial memory deficits. TAT-GluA2 3Y blocks the effect of NLRP3 deficiency on fear generalization, inhibits amphetamine-induced behavioral/neurochemical sensitization, weakens the unconditioned stimulus-conditioned stimulus association of morphine, and promotes the extinction of morphine CPP. TAT-GluA2 3Y can be used in studies related to fear generalization, ischemic stroke, hypoxia, drug addiction and opioid addiction .
Neral
Neral
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Cat. No.: HY-W923189
CAS No.: 106-26-3
Target:  

Interleukin Related COX TNF Receptor NOD-like Receptor (NLR) NO Synthase PERK p38 MAPK Reactive Oxygen Species (ROS) Caspase Autophagy Herbicide

Research Areas:  

Inflammation/Immunology Cancer

Neral is a plant-derived anti-inflammatory, antioxidant and anticancer agent. Neral inhibits the phosphorylation of ERK1/2, p38 MAPK and IκB in macrophages induced by LPS (HY-D1056), suppresses the secretion of TNF-α and IL-6, as well as the expression of pro-IL-1β, iNOS and COX-2 in cells, and reduces the production of ROS in cells. Neral inhibits the activation of the NLRP3 inflammasome, and decreases the activation of caspase-1 and the secretion of IL-1β in mouse macrophages. Neral induces autophagy, and exhibits antiproliferative activity both in in vitro breast cancer cell models and mouse xenograft models. Neral regulates brassinosteroid, jasmonic acid and ethylene signaling pathways, and induces the expression of AP2/ERF-ERF and bHLH family genes in rice roots. Neral acts as a herbicide safener, alleviates the damage induced by Fenoxaprop-P-ethyl (HY-B2013), and promotes the elongation of rice roots. Neral can be used in research related to breast cancer, inflammatory and immune system diseases, and herbicide safeners .
AP2A2 Human Pre-designed siRNA Set A
AP2A2 Human Pre-designed siRNA Set A
Cat. No.: HY-RS00785
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

AP2A2 Human Pre-designed siRNA Set A contains three designed siRNAs for AP2A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HW161023
HW161023
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Cat. No.: HY-159931
CAS No.: 2920698-73-1
Target:  

AAK1

Research Areas:  

Neurological Disease

HW161023 (compound 5) is an orally active AP2-associated protein kinase 1 (AAK1) inhibitor with IC50 values of 5.4 nM and 11.9 μM aganist of AAK1and hERG, respectively. HW161023 inhibits the pain in chronic constriction injury of the sciatic nerve rat model .
AAK1-IN-8
AAK1-IN-8
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Cat. No.: HY-174214
CAS No.: 2969205-90-9
Target:  

AAK1 Cyclin G-associated Kinase (GAK)

Research Areas:  

Infection

AAK1-IN-8 (Compound 18) is a pan-NAK inhibitor. AAK1-IN-8 inhibits AAK1 and GAK (EC50 values are 50 and 190 nM, respectively). AAK1-IN-8 inhibits the phosphorylation of AP2-µ2 subunit at T156 .
AAK1-IN-7
AAK1-IN-7
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Cat. No.: HY-174213
Target:  

AAK1 Cyclin G-associated Kinase (GAK)

Research Areas:  

Infection

AAK1-IN-7 (Compound 16) is a dual AAK1/GAK inhibitor (EC50 values are 40 and 80 nM, respectively). AAK1-IN-7 inhibits the phosphorylation of AP2-µ2 subunit at T156. AAK1-IN-7 has weak antiviral activity against RNA viruses .
AAK1-IN-6
AAK1-IN-6
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Cat. No.: HY-159879
CAS No.: 3061058-16-7
Target:  

AAK1 Dengue Virus

Research Areas:  

Infection

AAK1-IN-6 (Compound 23) is an inhibitor of AP-2-associated protein kinase 1 (AAK1, IC50 = 12 nM) with antiviral activity against the dengue virus (DNEV2, EC50 = 0.24 μM) and Venezuelan equine encephalitis virus (VEEV, EC50 = 0.30 μM). AAK1-IN-6 can be utilized in antiviral research .
Assay Types