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Isoforms Recommended: A-Raf
Results for "

ARaf

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

3

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-158115
    NST-628

    		Molecular Glues Raf MEK Cancer
    NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation. NST-628 also binds RAF and prevents the formation of BRAF-CRAF and BRAF-ARAF heterodimers, effectively inhibiting the RAS-MAPK pathway. NST-628 inhibits RAS- and RAF-driven cancers and demonstrated potent inhibition in mutant KRAS, NRAS, BRAF class II/III, and NF1-mutant tumors .
    NST-628
  • HY-178042
    SS-3091

    		Ras Akt ERK Cancer
    SS-3091 is a pan-KRas inhibitor active across KRas G12D, KRas G12C, KRas G12V, KRas G12S mutants, with minimal effects on non-KRas-driven cancer cells. SS-3091 binds to the KRas·ARaf interaction interface, destabilizes the complex, and attenuates KRas activity. SS-3091 suppresses phosphorylation of S6K, Akt, and ERK. SS-3091 reduces proliferation and decreases colony formation of cancer cells bearing KRas G12 mutations. SS-3091 can be used for the research of KRas-driven cancers .
    SS-3091
  • HY-RS18462
    Araf Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Araf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Araf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Araf Mouse Pre-designed siRNA Set A
    Araf Mouse Pre-designed siRNA Set A
  • HY-RS00886
    ARAF Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ARAF Human Pre-designed siRNA Set A contains three designed siRNAs for ARAF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ARAF Human Pre-designed siRNA Set A
    ARAF Human Pre-designed siRNA Set A
  • HY-18652A
    Avutometinib potassium

    Ro 5126766 potassium; CH5126766 potassium

    		 Raf MEK Cancer
    Avutometinib (CH5126766) (potassium) is a RAF/MEK clamp that potently inhibits RAF/MEK kinase activity and induces dominant negative RAF-MEK complexes preventing phosphorylation of MEK by ARAF, BRAF and CRAF. Avutometinib (potassium) shows anti-proliferative potency across tumor cell lines carrying KRAS mutations including PDAC cell lines. Avutometinib (potassium) induces tumor inhibition and increases survival in a KRAS/p53 pancreatic cancer mouse model. Avutometinib (potassium) is promising for research of low-grade-serous-ovarian-carcinoma (LGSOC), ovarian cancer and pancreatic ductal adenocarcinoma (PDAC) .
    Avutometinib potassium
  • HY-181067
    IK-595

    		MEK ERK Cancer
    IK-595 is a MEK1/MEK2 inhibitor with high affinity (7.39 nM).IK-595 blocks EGF-induced ERK1/2 phosphorylation in AsPC-1 cells with IC50 value of 0.1 nM. IK-595 has oral activity and blood-brain barrier penetration. IK-595 can be used for the research of Ras/MAPK pathway-altered cancers .
    IK-595
  • HY-169869
    pan-Raf/RTK inhibitor 1

    		Raf Cancer
    Pan-Raf/RTK inhibitor 1 (compound I-16) is a potent pan-Raf inhibitor with IC50 values of 3.49 nM (BRaf V600E), 8.86 nM (ARaf), 5.78 nM (BRaf WT), and 1.65 nM (CRaf). Pan-Raf/RTK inhibitor 1 exhibits antiproliferative activities against various cancer cell lines and can be utilized in cancer research .
    pan-Raf/RTK inhibitor 1
  • HY-162752
    Anticancer agent 250

    		Apoptosis Cancer
    Anticancer agent 250 (compound 104) has antitumor activity, inducing apoptosis, slowing proliferation, and degrading key oncogenic proteins (such as aRaf, CDK4 ) without inducing a heat shock response .
    Anticancer agent 250
  • HY-RS24943
    Araf Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Araf Rat Pre-designed siRNA Set A contains three designed siRNAs for Araf gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Araf Rat Pre-designed siRNA Set A
    Araf Rat Pre-designed siRNA Set A
  • HY-E70103I
    exo-α-1,3-Arabinofuranosidase, Penicillium chrysogenum

    		Biochemical Assay Reagents Others
    exo-α-1,3-Arabinofuranosidase, Penicillium chrysogenum (EC.3.2.1.55) is a glycoside hydrolase that cleaves terminal 1,3-linked-l-Araf residues present at the ends of branched arabinans and arabinogalactans .
    exo-α-1,3-Arabinofuranosidase, Penicillium chrysogenum

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