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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
ASBT
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "ASBT" in MCE Product Catalog:
13
Áreas de investigación:
Linerixibat (GSK2330672) is a highly potent, nonabsorbable and orally active apical sodium-dependent bile acid transporter (ASBT) inhibitor with an IC50 of 42 nM human ASBT. Linerixibat can be used as lipid-lowering agent. Linerixibat has the potential for type 2 diabetes and Primary Biliary Cholangitis treatment .
4
4 Cited Publications
Synonyms: A4250
Áreas de investigación:
Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .
Referencia número: HY-101190
No. CAS: 1025216-57-2
Synonyms: SHP626; LUM002
Áreas de investigación:
Volixibat (SHP626) is a highly selective, minimally absorbed, and competitive apical sodium-dependent bile acid transporter (ASBT) inhibitor. Volixibat has potential for treatment for non-alcoholic steatohepatitis (NASH) .
Referencia número: HY-148795
No. CAS: 2460667-52-9
Áreas de investigación:
Ritivixibat is an apical sodium-dependent bile acid transporter (ASBT/IBAT) inhibitor. Ritivixibat blocks ASBT/IBAT function, thereby reducing bile acid reabsorption, regulating bile acid homeostasis and alleviating liver injury. Ritivixibat protects cholangiocytes from damage caused by cytotoxic bile acids. Ritivixibat is applicable to research related to primary sclerosing cholangitis .
Áreas de investigación:
SC-435 is an orally effective apical sodium codependent bile acid transporter (ASBT) inhibitor. SC-435 effectively removes neurotoxic bile acids and ammonia from the blood by inhibiting intestinal ASBT, thereby alleviating liver and brain damage caused by liver failure. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations .
Referencia número: HY-RS12987
Target:
Áreas de investigación:
Slc10a2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Slc10a2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS12988
Target:
Áreas de investigación:
Slc10a2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Slc10a2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-168523
No. CAS: 259528-99-9
Áreas de investigación:
S1647 is a ASBT and SOAT dual inhibitor. S1647 can be used in the study of intrahepatic cholestasis, cholestatic pruritus, and obstipation .
Referencia número: HY-RS12986
Target:
Áreas de investigación:
SLC10A2 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC10A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-109120R
No. CAS: 501692-44-0
Synonyms: A4250 (Standard)
Áreas de investigación:
Odevixibat (Standard) is the analytical standard of Odevixibat. This product is intended for research and analytical applications. Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .
Referencia número: HY-109120S
Synonyms: A4250-d5
Referencia número: HY-109120S1
Synonyms: A4250-13C6
Referencia número: HY-P705614
Pureza: Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: SLC10A2; Na+/Taurocholate Cotransporting Polypeptide 2; Prev. ASBT; Ileal Sodium/Bile Acid Cotransporter; Prev. ISBT; Ileal Bile Acid Transporter; NTCP2; Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 2; IBAT; Ileal Apical Sodium
Species:
Human
Source:
HEK293
Referencia número: HY-101190A
Synonyms: (3R,4S,5S)-SHP626; (3R,4S,5S)-LUM002
Target:
Áreas de investigación:
(3R,4S,5S)-Volixibat ((3R,4S,5S)-SHP626) is an isomer of Volixibat (HY-101190). Volixibat is a highly selective, minimally absorbed, and competitive apical sodium-dependent bile acid transporter (ASBT) inhibitor. (3R,4S,5S)-Volixibat may be used in research on non-alcoholic steatohepatitis (NASH) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
