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Amylases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amylases (89) Amyloid-β (1) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (3) Autophagy (3) Bacterial (3) Bcl-2 Family (1) Biochemical Assay Reagents (11) Bombesin Receptor (3) Caspase (1) CGRP Receptor (1) Cholecystokinin Receptor (7) Cholinesterase (ChE) (4) COX (3) Dipeptidyl Peptidase (5) DNA/RNA Synthesis (1) Drug Metabolite (1) Endogenous Metabolite (10) Environmental Pollutants (2) Fatty Acid Synthase (FASN) (2) Fungal (2) GLUT (3) Glycosidase (62) HDAC (1) Integrin (1) Lipase (4) MDM-2/p53 (1) Monoamine Oxidase (1) Neuropeptide Y Receptor (1) NF-κB (8) NO Synthase (1) NOD-like Receptor (NLR) (2) P-glycoprotein (1) P2Y Receptor (1) p38 MAPK (1) Parasite (1) PARP (1) Phosphatase (2) PPAR (2) Pregnane X Receptor (PXR) (1) Pyroptosis (2) Reactive Oxygen Species (ROS) (2) Reference Standards (8) SARS-CoV (1) Somatostatin Receptor (2) TNF Receptor (3) Tyrosinase (2) β-glucuronidase (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (3) Endocrinology (4) Infection (3) Inflammation/Immunology (27) Metabolic Disease (109) Neurological Disease (6)
Oligonucleotides:	Cholesterol (1)

151

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Oligonucleotides

Targets Recommended: Amylases

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132179

Fucoidan Maximum Cited Publications 6 Publications Verification	Glycosidase	Cardiovascular Disease Metabolic Disease Cancer
Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities .

HY-N1425

Tiliroside 3 Publications Verification	Others	Metabolic Disease
Tiliroside, a glycosidic flavonoid, possesses anti-diabetic activities. Tiliroside is a noncompetitive inhibitor of *α-amylase* with a K_i value of 84.2 μM. Tiliroside inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract .

HY-P3462A

Cagrilintide acetate 3 Publications Verification	CGRP Receptor	Metabolic Disease
Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies .

HY-W009694

3,5-Dinitrosalicylic acid	Biochemical Assay Reagents	Others
3,5-Dinitrosalicylic acid the derivative of salicylic acid. 3,5-Dinitrosalicylic acid is used in the α-amylase assay, carbohydrase assay, and for the colorimetric determination of reducing substances .

HY-B2193

α-Amylase 2 Publications Verification	Environmental Pollutants Amylases	Others
α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.

HY-N0668

Rubusoside 2 Publications Verification	GLUT Amylases NF-κB	Metabolic Disease Inflammation/Immunology Cancer
Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase) .

HY-N1495

Maltopentaose Maltopentose	Amylases	Others
Maltopentaose is the shortest chain oligosaccharide. Maltopentaose is a substrate for *α-amylases. Maltopentaose can be classified as maltodextrin and is also used in a study to investigate glycation and phosphorylation of α-lactalbumin. Maltopentaose is used to study the inhibition kinetics of human pancreatic α-amylase* by dehydrodieugenol B .

HY-153102

G3-CNP	Biochemical Assay Reagents	Others
G3-CNP is an α-amylase substrate. The absorbance of G3-CNP cleavage product 2-chloro-4-nitrophenol is measured at 405 nm, which can be used to detect enzyme activity .

HY-B2192

*Amylase*	Amylases	Metabolic Disease Cancer
Amylase is an enzyme produced by pancreas and salivary glands, catalyzing the hydrolysis of starch into sugars. Amylase are broadly classified into α, β, and γ subtypes .

HY-112835

Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside pNP-G7	Amylases Glycosidase	Inflammation/Immunology
Ethylidene-4-nitrophenyl-α-D-Maltoheptaoside (EPS; pNP-G7) serves as a substrate for α-amylase. In the presence of an auxiliary enzyme such as α-glucosidase (α-glucosidase), Ethylidene-4-nitrophenyl-α-D-Maltoheptaoside is degraded by amylase (Amylase) to release a chromophore, enabling the measurement of amylase activity. Ethylidene-4-nitrophenyl-α-D-Maltoheptaoside is applicable for the diagnosis of pancreatitis ^[2].

HY-P2968

Bacterial α-Amylase	Amylases	Others
Bacterial α-Amylase catalyses the hydrolysis of internal α-1,4-glycosidic linkages in starch in low molecular weight products, such glucose, maltose and maltotriose units. Bacterial α-Amylase is often used in biochemical studies .

HY-P2762

*α-Amylase* from Aspergillus oryzae**	Amylases	Others
α-Amylase from Aspergillus oryzae is an *amylase. α-Amylase* from Aspergillus oryzae can be used for various biochemical studies .

HY-N6675

Gardenia yellow	Amylases Glycosidase	Inflammation/Immunology
Gardenia yellow is a competitive inhibitor of *α-Amylase* (HY-B2193) and α-glucosidase. Gardenia yellow can bind to the catalytic sites of *α-Amylase* and α-glucosidase, inhibit starch digestion, and significantly increase the contents of resistant starch and slowly digestible starch in starch-based systems. Gardenia yellow reduces the glycemic index and hydrolysis index. Gardenia yellow can be used in diabetes-related research .

HY-P1096

A71623	Cholecystokinin Receptor	Metabolic Disease
A71623, a CCK-4-based peptide, is a potent and highly selective CCK-A full agonist. The IC₅₀s for A-71623 are 3.7 nM in guinea pig pancreas (CCK-A) and 4500 nM in cerebral cortex (CCK-B) in radioligand binding assays, respectively .

HY-B2193A

*α-Amylase, Human Saliva* 1,4-alpha-D-Glucan-glucanohydrolase, ptyalin	Biochemical Assay Reagents	Metabolic Disease Inflammation/Immunology
α-Amylase, Human Saliva (1,4-alpha-D-Glucan-glucanohydrolase) is a hydrolase enzyme that can be isolated from human saliva. α-Amylase, Human Saliva catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose. α-Amylase, Human Saliva can be used in life science research .

HY-B2193C

*α-Amylase, Porcine Pancreatic* 1,4-alpha-D-Glucan-glucanohydrolase, amy2, PPA, PA	Biochemical Assay Reagents	Others
α-Amylase, Porcine Pancreatic (1,4-alpha-D-Glucan-glucanohydrolase) is a hydrolase enzyme that can be isolated from porcine pancreatic. α-Amylase, Porcine Pancreatic catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose. α-Amylase, Porcine Pancreatic can be used in life science research .

HY-B2193B

*α-Amylase, Human Pancreas* Amylase, a-Amylase, 1,4-a-D-glucan glucanohydrolase, glycogenase	Biochemical Assay Reagents	Others
α-Amylase, Human Pancreas (Amylase) is a hydrolase enzyme that can be isolated from human pancreas. α-Amylase, Human Pancreas catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose. α-Amylase, Human Pancreas can be used in life science research .

HY-135530

Chinese gallotannin	Amylases	Metabolic Disease
Chinese gallotannin is a non-specific promiscuous *α-amylase* inhibitor with a K_i of 0.82 μg/mL for human salivary α-amylase. Chinese gallotannin can be used for the research of diabetes .

HY-W005598

2-Hydroxyquinoline	Glycosidase Amylases	Metabolic Disease
2-Hydroxyquinoline is an inhibitor of α-glucosidase and *α-amylase* with IC₅₀ values of 64.4 µg/mL and 130.5 µg/mL, respectively. 2-Hydroxyquinoline can be used in the study of diabetes .

HY-153101

Gal-G2-CNP	Biochemical Assay Reagents	Others
Gal-G2-CNP is a galactopyranosyl maltoside. Gal-G2-CNP is an amylase substrate specific to salivary amylase, which produces a yellow hydrolyzate upon decomposition. Gal-G2-CNP can serve as a matrix for the assays of novel amylases and pancreatic amylases .

HY-P3112

ICI 216140	Bombesin Receptor	Neurological Disease
ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC₅₀ of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure .

HY-P2770

*β-Amylase, Bacilus subtilis*	Endogenous Metabolite	Others
β-Amylase, Bacilus subtilis has abundant starch degrading activities. β-Amylase can be used for various biochemical studies .

HY-E70183

Lysosomal α-Glucosidase EC:3.2.1.20; GAA	Biochemical Assay Reagents	Others
Lysosomal α-Glucosidase (EC:3.2.1.20) is a γ-amylase with specificity for glycogen and several natural and synthetic oligoglucosides .

HY-200541

Dihydro-α-ionone	Others	Metabolic Disease
Dihydro-α-ionone is a volatile compound found in the essential oil of Persicaria hydropiper L. leaves. The essential oil can inhibit α-glucosidase and α-amylase activities .

HY-N8326

Maltononaose	Others	Others
Maltononaose is a linear oligosaccharide consisting of 9 glucose units linked by alpha-1, 4-glucoside bonds. Maltononaose is used as a substrate to study the subsites affinity of glucoamylase. Maltononaose can be used to determine the activity of amylase and to optimize the process of starch hydrolysis .

HY-178363

*α-Amylase-IN-13*	Amylases	Metabolic Disease Endocrinology
α-Amylase-IN-13 is an orally active, selective, brain-penetrant *α-amylase* inhibitor (IC₅₀ = 0.71 μM). α-Amylase-IN-13 inhibits α-amylase through a mixed type of inhibition mechanism. α-Amylase-IN-13 leads to a significant reduction in blood glucose level in diabetic rats. α-Amylase-IN-13 causes significant histopathological improvements in the kidney, liver, and pancreas. α-Amylase-IN-13 can be used for the study of diabetic complications .

HY-179141

*α-Amylase/α-Glucosidase-IN-23*	Amylases Glycosidase	Metabolic Disease
α-Amylase/α-Glucosidase-IN-23 (Compound 5e) is a *α-Amylase/α-Glucosidase* inhibitor with IC₅₀ values of 73.68 nM for α-glucosidase and 146.18 nM for α-amylase. α-Amylase/α-Glucosidase-IN-23 can be used in the research of hypoglycemia .

HY-146752

*α-Amylase-IN-1*	Amylases	Others
α-Amylase-IN-1 is a potent *α-amylase* inhibitor with an IC_{50 of 4.46 μM .}

HY-149008

*α-Amylase-IN-3*	Amylases Cholinesterase (ChE)	Inflammation/Immunology
α-Amylase-IN-3 (Compound 4) is the inhibitor for *α-Amylase, AChE* and AChE with IC₅₀s of 18.04 μM, 21.04 μM and 22.2 μM, respectively. α-Amylase-IN-3 exhibits antioxidant activity. α-Amylase-IN-3 can be used in research of diabetes and oxidative stress associated disease .

HY-133718

Acarviosin (S)-Acarviosin	Amylases	Others
Acarviosin, a pseudodisaccharide moiety, is a part of the potent inhibitor of α-amylase .

HY-N17254

Onjisaponin R	Amylases	Metabolic Disease
Onjisaponin R is an *α-amylase* inhibitor. Onjisaponin R can be used in diabetes research .

HY-118194

A-65186	Cholecystokinin Receptor	Others
A-65186 is a CCK-A receptor antagonist with the activity of inhibiting CCK8-induced amylase secretion. A-65186 has high binding affinity for pancreatic CCK-A receptors, is more than 500 times more selective for CCK-A receptors than for CCK-B receptors, and can inhibit CCK8-induced amylase secretion.

HY-N10413

Diphlorethohydroxycarmalol	Glycosidase	Metabolic Disease
Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and *α-amylase* inhibitor with IC₅₀s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities .

HY-106525

Aclatonium napadisylate	Cholinesterase (ChE)	Inflammation/Immunology
Aclatonium napadisylate is a cholinergic agonist. Aclatonium napadisylate can increase amylase release and Ca ²⁺ efflux. Aclatonium napadisylate can stimulate pancreatic exocrine secretion and increase motility and peristalsis of the gastrointestinal tract. Aclatonium napadisylate can be used for the research of gastrointestinal disorders .

HY-161944

*α-Amylase-IN-8*	Amylases	Metabolic Disease
α-Amylase-IN-8 (compound 44) is an *α-amylase* inhibitor (IC₅₀=58.1 μM). α-Amylase-IN-8 can be used in the research of type 2 diabetes .

HY-178935

*α-Amylase-IN-14*	Amylases Reactive Oxygen Species (ROS)	Metabolic Disease Inflammation/Immunology
α-Amylase-IN-14, a derivative of Nicotinic (HY-B0143), is an *α-amylase* inhibitor and has good interactions with α-amylase protein (-5.55 kcal/mol). α-Amylase-IN-14 is a dual anti-inflammatory and anti-hyperglycemic agent. α-Amylase-IN-14 exhibits good results against DPPH and ABTS radicals. α-Amylase-IN-14 can be used for the study of diabetes .

HY-155241

*α-Amylase/α-Glucosidase-IN-4*	Glycosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity .

HY-175605

*α-Amylase/α-Glucosidase-IN-21*	Glycosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-21 (Compound 4) is a dual-functional inhibitor of α-Glucosidase and *α-Amylase* with IC₅₀s of 0.27 and 0.19 µg/mL for α-Glucosidase and α-Amylase, respectively. α-Amylase/α-Glucosidase-IN-21 has an antidiabetic activity.α-Amylase/α-Glucosidase-IN-21 can be used for diabetes mellitus research .

HY-149973

*α-Amylase-IN-4*	Amylases	Metabolic Disease
α-Amylase-IN-4 (Compd 10y) show maximum inhibition of amylase activity with IC₅₀ value 17.83 ± 0.14 μg/mL .

HY-149313

*α‑Amylase-IN-1*	Amylases	Metabolic Disease
α Amylase-IN-1 (Compound 11) is an *α-Amylase* inhibitor with an IC₅₀ value of 0.5509 μM. α Amylase-IN-1 has antioxidant activity with an IC₅₀ value of 53.49 μM for scavenging DPPH free radicals. IC₅₀ can be used in the study of diabetes and oxidative stress-related diseases.

HY-W112651

2,4,6-Triphenylaniline	Glycosidase Amylases	Metabolic Disease
2,4,6-Triphenylaniline has anti-diabetic activity and can be encapsulated in nano-emulsions (NE) to enhance stability and permeability. The NE loaded with 2,4,6-Triphenylaniline inhibits α-glucosidase and *α-amylase* .

HY-N0668R

Rubusoside (Standard)	GLUT Amylases NF-κB Reference Standards	Metabolic Disease Inflammation/Immunology Cancer
Rubusoside (Standard) is the analytical standard of Rubusoside. This product is intended for research and analytical applications. Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits *NF-κB and α-amylase* (α-amylase) .**

HY-169737

Inulobiose	Glycosidase Amylases	Metabolic Disease
Inulobiose is a difructan disaccharide that can be isolated from Pistacia vera L.. Inulobiose inhibits α-glycosidase and *α-amylase* activities with IC₅₀s of 1.87 and 40.72 mg/mL, respectively. Inulobiose can be used for the research of diabetes and glomerular filtration rate testing .

HY-N0419R

Quercimeritrin (Standard) Quercetin-7-O-β-D-glucopyranoside (Standard)	Reference Standards Others	Metabolic Disease
Quercimeritrin (Standard) is the analytical standard of Quercimeritrin. This product is intended for research and analytical applications. Quercimeritrin, isolated from the leaves of Ixeridium dentatum, exhibits significant amylase activity .

HY-P1133

Galanin (2-29) (rat) Rat galanin(2-29)	Neuropeptide Y Receptor	Others
Galanin (2-29) (rat) inhibits rat pancreatic protein and CCK-8-stimulated amylase secretion. Galanin (2-29) (rat) is an GAL2R agonist (K_i: 3.5 nM) .

HY-159491

DPP-4-IN-11	Dipeptidyl Peptidase Glycosidase Amylases	Metabolic Disease
DPP-4-IN-11 (compound 10) is an orally active DPP-4 inhibitor (IC₅₀=2.75 μM) with anti-type 2 diabetes activity. DPP-4-IN-11 exerts its glucose-lowering effect by inhibiting the activities of α-glucosidase (IC₅₀=3.02 μM) and *α-amylase* (IC₅₀=3.3 μM) .

HY-161782

*α-Amylase-IN-7*	Amylases	Metabolic Disease
α-Amylase-IN-7 (Compound 6e) is an inhibitor for *α-Amylase* with an IC₅₀ of 40 μM. α-Amylase-IN-7 exhibits potential as an antidiabetic agent .

HY-149557

*α-Amylase/α-Glucosidase-IN-5*	Glycosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-5 (compound 4l) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 5.96 μM and 1.62 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity .

HY-168495

*α-Amylase-IN-12*	Amylases Glycosidase	Metabolic Disease
α-Amylase-IN-12 (Compound 5e) is an *α-amylase* inhibitor (IC₅₀: 0.15 mM) with a mixed inhibition. α-Amylase-IN-12 has an IC₅₀ of 9.40 mM against α-glucosidase. α-Amylase-IN-12 promotes glucose uptake in yeast cells and exhibits significant antiglycation activity at high concentrations. α-Amylase-IN-12 can be used for the research of diabetes .

HY-170548

*α-Amylase-IN-10*	Amylases	Metabolic Disease
α-Amylase-IN-10 (Compound 15n) is an inhibitor for *α-Amylase* with an IC₅₀ of 5.00 µM. α-Amylase-IN-10 can be used for research of type 2 diabetes mellitus .

Cat. No.	Product Name	Type

HY-W009694

3,5-Dinitrosalicylic acid	Biochemical Assay Reagents
3,5-Dinitrosalicylic acid the derivative of salicylic acid. 3,5-Dinitrosalicylic acid is used in the α-amylase assay, carbohydrase assay, and for the colorimetric determination of reducing substances .

HY-153102

G3-CNP	Biochemical Assay Reagents
G3-CNP is an α-amylase substrate. The absorbance of G3-CNP cleavage product 2-chloro-4-nitrophenol is measured at 405 nm, which can be used to detect enzyme activity .

HY-160113

Sodium phosphate buffer 0.02 M, pH 6.9

Biochemical Assay Reagents

Sodium phosphate buffer 0.02 M, pH 6.9 is a commonly used aqueous biological buffer that maintains a stable pH value. Sodium phosphate buffer 0.02 M, pH 6.9 is often used in enzyme activity assays, such as α-amylase assays. Sodium phosphate buffer 0.02 M, pH 6.9 is prepared by mixing disodium hydrogen phosphate (Na₂HPO₄) (HY-B2243) and sodium dihydrogen phosphate (NaH₂PO₄) (HY-Y0308) to a total concentration of 0.02 M .

HY-W005598

2-Hydroxyquinoline	Biochemical Assay Reagents
2-Hydroxyquinoline is an inhibitor of α-glucosidase and *α-amylase* with IC₅₀ values of 64.4 µg/mL and 130.5 µg/mL, respectively. 2-Hydroxyquinoline can be used in the study of diabetes .

HY-153101

Gal-G2-CNP	Biochemical Assay Reagents
Gal-G2-CNP is a galactopyranosyl maltoside. Gal-G2-CNP is an amylase substrate specific to salivary amylase, which produces a yellow hydrolyzate upon decomposition. Gal-G2-CNP can serve as a matrix for the assays of novel amylases and pancreatic amylases .

HY-E70183

Lysosomal α-Glucosidase EC:3.2.1.20; GAA	Biochemical Assay Reagents
Lysosomal α-Glucosidase (EC:3.2.1.20) is a γ-amylase with specificity for glycogen and several natural and synthetic oligoglucosides .

HY-N1731

2′-Hydroxy-5′-methoxyacetophenone

Biochemical Assay Reagents

2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inﬂammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC₅₀s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity .

HY-137228

4-Nitrophenylmaltohexaoside	Biochemical Assay Reagents
4-Nitrophenylmaltohexaoside is a chromogenic substrate targeting α-amylase.

HY-137785

2-Chloro-4-nitrophenyl-β-D-maltotrioside	Biochemical Assay Reagents
2-Chloro-4-nitrophenyl-β-D-maltotrioside is a chromogenic substrate used in bioluminescent and fluorescent assays to detect α-amylase.

Cat. No.	Product Name	Target	Research Area

HY-P3462A

Cagrilintide acetate 3 Publications Verification	CGRP Receptor	Metabolic Disease
Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies .

HY-P1096

A71623	Cholecystokinin Receptor	Metabolic Disease
A71623, a CCK-4-based peptide, is a potent and highly selective CCK-A full agonist. The IC₅₀s for A-71623 are 3.7 nM in guinea pig pancreas (CCK-A) and 4500 nM in cerebral cortex (CCK-B) in radioligand binding assays, respectively .

HY-P0039

BIM-26226	Bombesin Receptor	Cancer
BIM-26226 is a selective gastrin-releasing peptide receptor (GRPR) (IC₅₀ = 6 nM) and bombesin receptor (BN receptor) antagonist. BIM-26226 antagonizes BN- or GRP-stimulated amylase release with IC₅₀ values of 0.3 nM and 0.2 nM, respectively. BIM-26226 is specific for the GRP-preferring BN receptor subtype with no interference with GRP receptor system. BIM-26226 can induce the synthesis of somatostatin receptor but has no significant effect on tumor growth .

HY-P3377

Rimtoregtide	Peptides	Inflammation/Immunology
Rimtoregtide is a polypeptide compound which significantly reduces the increase in the levels of amylase and lipase in the blood caused by acute pancreatitis. Rimtoregtide has the potential for the research of pancreatitis and acute pancreatitis (extracted from patent WO2018205233A1).

HY-P3112

ICI 216140	Bombesin Receptor	Neurological Disease
ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC₅₀ of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure .

HY-P3899A

[Nle8] Somatostatin (1-28) TFA	Somatostatin Receptor	Metabolic Disease
[Nle8] Somatostatin (1-28) TFA is a derivative of somatosttin (1-28) with norleucine replacing methionine in position 8. [Nle8] Somatostatin (1-28) TFA increases the amylase release.[Nle8] Somatostatin (1-28) TFA increases the cyclic AMP in pancreatic acini .

HY-P1133

Galanin (2-29) (rat) Rat galanin(2-29)	Neuropeptide Y Receptor	Others
Galanin (2-29) (rat) inhibits rat pancreatic protein and CCK-8-stimulated amylase secretion. Galanin (2-29) (rat) is an GAL2R agonist (K_i: 3.5 nM) .

HY-P3899

[Nle8] Somatostatin (1-28)	Somatostatin Receptor	Metabolic Disease
[Nle8] Somatostatin (1-28) is a derivative of somatosttin (1-28) with norleucine replacing methionine in position 8. [Nle8] Somatostatin (1-28) increases the amylase release.[Nle8] Somatostatin (1-28) increases the cyclic AMP in pancreatic acini .

HY-103282

[D-Phe12]-Bombesin	Bombesin Receptor	Others
[D-Phe12]-Bombesin is a derivative of Bombesin (HY-P0195) and an antagonist for bombesin receptor with K_i of 4.7 μM. [D-Phe12]-Bombesin inhibits the Bombesin (HY-P0195)-induced amylase release, with IC₅₀ of 4 μM .

HY-P2055

A-57696	Endogenous Metabolite	Endocrinology
A-57696 is a cholecystokinin antagonist with selective activity at cortical CCK-B receptors (IC50 = 25 nM). A-57696 behaves as a competitive antagonist in reversing CCK8-stimulated pancreatic alpha-amylase secretion and phosphatidylinositol degradation. A-57696 fails to induce gallbladder contraction and inhibits CCK8-induced contraction. A-57696 behaves as a partial agonist at CCK-B/gastrin receptors on NCI-H345 cells, achieving 80% of the maximal CCK8 response. A-57696 and CCK8 inhibit each other in a calcium mobilization assay .

Cat. No.	Product Name		Classification

HY-B1393

Dehydrocholic acid Dehydrocholate		Cholesterol
Dehydrocholic acid (Dehydrocholate) is an orally active hydrocholeretic agent. Dehydrocholic acid modulates Autophagy, reduces serum *amylase* and lipase levels. Dehydrocholic acid has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid can be used in the study of acute biliary pancreatitis and obstructive jaundice .

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