16 Results for "

Angiopoietins

" in MedChemExpress (MCE) Product Catalog:
Products (16)

16 Results for "Angiopoietins" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99194
CAS No.: 1446419-85-7
Synonyms: REGN1500

Target:  

ANGPTL

Evinacumab (REGN1500) is a human anti-ANGPTL3 (angiopoietin-like protein 3) monoclonal antibody (IgG4 class antibody). Evinacumab reduces plasma lipids in dyslipidemic mice by blocking ANGPTL3. Evinacumab can be used in studies of homozygous familial hypercholesterolaemia (HoFH), refractory hypercholesterolaemia (both familial and non-familial) and severe hypertriglyceridaemia .
loading...
    loading...
Cat. No.: HY-P99116
CAS No.: 1607793-29-2
Synonyms: RG7716; RO-6867461
Faricimab, an overall good safety and tolerability profile, is a bispecific antibody targeting Angiopoietin-2 (Ang-2) and vascular endothelial growth factor-A (VEGF-A). Faricimab prevents retinal vascular leakage, cell death and inflammation in retinal ischemia/reperfusion (I/R) injury and sCNV mouse models. Faricimab demonstrates statistically superior visual acuity gains versus Ranibizumab (HY-P9951). Faricimab can be used for retinal diseases, such as age-related macular degeneration (w-AMD), diabetic macular edema (DME) and macular edema following retinal vein occlusion (RVO) .
loading...
    loading...
Cat. No.: HY-P99330
CAS No.: 1448221-05-3
Synonyms: Anti-Human VEGFA Recombinant Antibody; RO5520985

Target:  

VEGFR Tie

Research Areas:  

Cancer

Vanucizumab is a first-in-class, bispecific IgG1-like monoclonal antibody that simultaneously blocks VEGF-A and angiopoietin-2 (Ang-2) from interacting with their receptors. Vanucizumab has antiangiogenic and anticancer effects .
loading...
    loading...
Cat. No.: HY-P99036
CAS No.: 1296818-77-3
Synonyms: REGN910
Target:  

Tie

Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches .
loading...
    loading...
Cat. No.: HY-P99546
CAS No.: 894356-79-7
Synonyms: 2xCon4C; AMG 386

Target:  

Tie

Research Areas:  

Cardiovascular Disease Cancer

Trebananib (2xCon4C) is an Fc fusion peptibody. Trebananib exerts its effects by blocking the binding of angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2) to the TIE2 receptor. Trebananib has anti-angiogenic and anti-tumor activities .
loading...
    loading...
Cat. No.: HY-P99510
CAS No.: 2415205-37-5
Synonyms: LY-3127804

Target:  

Tie

Research Areas:  

Inflammation/Immunology Cancer

Zansecimab (LY-3127804) is a monoclonal antibody against angiopoietin 2 (Ang‑2). Zansecimab can be used in research on angiogenesis, immunomodulation and anti-tumor activity .
loading...
    loading...
Cat. No.: HY-P990625
CAS No.: 1415642-51-1

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

MEDI-3617 is a humanized antibody expressed in CHO cells, targeting Ang2/ANGPT2/Angiopoietin2. MEDI-3617 has a huIgG2 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for MEDI-3617 can refer to Human IgG2 kappa, Isotype Control (HY-P99002).
loading...
    loading...
Cat. No.: HY-153497A
CAS No.: 2172852-12-7
Purity:  98.33%
Synonyms: IONIS ANGPT-L3Rx sodium; ISIS 703802 sodium
Target:  

ANGPTL

Research Areas:  

Metabolic Disease

Vupanorsen (sodium) is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen (sodium) lowers triglycerides and atherogenic lipoproteins.
loading...
    loading...
Cat. No.: HY-P990334

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Anti-ANGPT2 Antibody is a CHO-expressed human antibody that targets Ang2/ANGPT2/Angiopoietin2. Anti-ANGPT2 Antibody has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-ANGPT2 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
loading...
    loading...
Cat. No.: HY-153497
CAS No.: 2097587-62-5
Synonyms: IONIS ANGPT-L3Rx; ISIS 703802
Target:  

ANGPTL

Research Areas:  

Metabolic Disease

Vupanorsen is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen lowers triglycerides and atherogenic lipoproteins.
loading...
    loading...
Cat. No.: HY-P4866
CAS No.: 1361235-89-3
Q-Peptide is an angiopoietin-1 derived peptide (QHREDGS). Q-Peptide interacts with β1-integrin, binds to integrins on the surface of osteoblasts, and serves as an acyl donor substrate for Streptomyces mobaraensis transglutaminase. Q-Peptide activates Akt, MAPKp42/44, ILK, ERK1/2, and downregulates caspase-3/7. Q-Peptide inhibits cell apoptosis, enhances cell adhesion and migration, and promotes osteoblast differentiation, bone matrix deposition and mineralization. Q-Peptide can be used in studies related to myocardial infarction, bone regeneration, diabetic wound repair and human induced pluripotent stem cells .
loading...
    loading...
Cat. No.: HY-P991663

Target:  

Tie

Research Areas:  

Cancer

AMG-780 is a fully human IgG2 antibody that targets angiopoietin 1 (Ang1) (IC50 = 4.5 nM) and angiopoietin 2 (Ang2) (IC50 = 0.06 nM). AMG-780 inhibits tumor growth in the Colo205 xenograft mouse model by inhibiting both Ang1 and Ang2. AMG-780 is indicated for the research of cancers such as colon cancer .
loading...
    loading...
Cat. No.: HY-14243
CAS No.: 856692-39-2
CEP-14083 is a ATP-competitive ALK kinase inhibitor with an IC50 value in enzymatic assays of 2 nM. CEP-14083 also inhibits other kinases, such as insulin receptor (IR), vascular endothelial growth factor receptor 2 (VEGFR2), angiopoietin-1 receptor (TIE2) and dual leucine zipper kinase (DLK). CEP-14083 suppresses CD274 mRNA expression and the NPM/ALK function in the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells. CEP-14083 is promising for research of lymphoma .
loading...
    loading...
Cat. No.: HY-160043
Research Areas:  

Cancer

AL6 aptamer sodium is a short-chain nucleic acid aptamer chemically synthesized in vitro. AL6 aptamer sodium specifically targets Angiopoietin (Ang) for the specific detection of Ang. The AL6 aptamer binds to Ang, causing the rotational motion of the fluorophore on the AL6 aptamer to become slower. The concentration of Ang in the test solution can be quantified by detecting the anisotropy of AL6 aptamer/Ang .
loading...
    loading...
Cat. No.: HY-185318
CAS No.: 3078403-66-1
Target:  

ANGPTL

Research Areas:  

Metabolic Disease

Lexosiran is a siRNA that inhibits ANGPTL3 (angiopoietin-related protein 3) synthesis, and can be use for the study of antihyperlipidaemic.
loading...
    loading...
Cat. No.: HY-185318A
Target:  

ANGPTL

Research Areas:  

Metabolic Disease

Lexosiran sodium is a siRNA that inhibits ANGPTL3 angiopoietin-related protein 3 synthesis, and can be use for the study of antihyperlipidaemic.
loading...
    loading...
  • 1