2. Inhibitory Antibodies
  3. Evinacumab

Evinacumab  (Synonyms: REGN1500)

Cat. No.: HY-P99194 Purity: 98.98%
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Evinacumab (REGN1500) is a human anti-ANGPTL3 (angiopoietin-like protein 3) monoclonal antibody (IgG4 class antibody). Evinacumab reduces plasma lipids in dyslipidemic mice by blocking ANGPTL3. Evinacumab can be used in studies of homozygous familial hypercholesterolaemia (HoFH), refractory hypercholesterolaemia (both familial and non-familial) and severe hypertriglyceridaemia.

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Evinacumab Chemical Structure

Evinacumab Chemical Structure

CAS No. : 1446419-85-7

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Description

Evinacumab (REGN1500) is a human anti-ANGPTL3 (angiopoietin-like protein 3) monoclonal antibody (IgG4 class antibody). Evinacumab reduces plasma lipids in dyslipidemic mice by blocking ANGPTL3. Evinacumab can be used in studies of homozygous familial hypercholesterolaemia (HoFH), refractory hypercholesterolaemia (both familial and non-familial) and severe hypertriglyceridaemia[1].

IC50 & Target

ANGPTL3[1].
In Vivo

Evinacumab (REGN1500) (10 mg/kg; s.c.; single) lowers serum TGs in normolipidemic C57Bl/6 mice and increases postheparin plasma LPL activity[1].
Evinacumab (25 mg/kg; s.c.; once weekly for 8 weeks) lowers serum TG and cholesterol levels in dyslipidemic C57Bl/6 mice[1].
Evinacumab (10 mg/kg; s.c.; single) lowers serum HDL-C by an EL-dependent mechanism in Lipg-/- mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl/6 mice (8-week-old)[1].
Dosage: 10 mg/kg
Administration: Subcutaneous injection, single.
Result: Caused a rapid reduction in TG levels with the maximal mean level of serum TG 55% lower than control group, and reduced 26% levels of TC.
Significantly reduced VLDL-TG, VLDL-cholesterol, and HDL-C levels.
Increased postheparin plasma LPL and improved lipid tolerance.
Animal Model: Male C57Bl/6 mice (8-week-old; on a high-fat high-cholesterol diet)[1].
Dosage: 25 mg/kg
Administration: Subcutaneous injection, once weekly for 8 weeks.
Result: Led to a marked and sustained reduction in circulating TG levels (up to 53%).
Significantly reduced levels of TC (up to 35%) and LDL-C (up to 45%).
Animal Model: Lipg-/- mice[1].
Dosage: 10 mg/kg
Administration: Subcutaneous injection, single.
Result: Blocked the inhibitory action of ANGPTL3 on EL with an IC50 value of 96 nM.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Evinacumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.98%

COA (231 KB)

Handling Instructions (2659 KB)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Evinacumab1446419-85-7REGN1500REGN 1500REGN-1500OthersIgG4HoFHrefractory hypercholesterolaemiasevere hypertriglyceridaemiaplasma lipidsInhibitorinhibitorinhibit

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