4 Results for "

Azaleatin

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "Azaleatin" in MCE Product Catalog:

Azaleatin
Azaleatin
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Cat. No.: HY-N7653
CAS No.: 529-51-1
Category:  

Flavonols Flavonoids Carthamus tinctorius L. Metabolic Disease Phenols Polyphenols Plants Compositae Disease Research Fields

Target:  

Dipeptidyl Peptidase NF-κB MyD88 JAK Toll-like Receptor (TLR) STAT Interleukin Related COX Reactive Oxygen Species (ROS) Glutathione S-transferase SOD Bcl-2 Family Caspase Apoptosis Dengue Virus

Azaleatin is an orally active inhibitor of hQC, NS2B-NS3 protease and E. coli β-glucuronidase, with IC50 values of 1.1 μM, 38.00 μg/mL and 0.57 μM, respectively. Azaleatin inhibits the activities of NF-κB, MyD88, JAK1, TLR4, STAT3, IL-1β, IL-6, COX-2, TNF-α and β-glucuronidase, blocks pro-inflammatory signaling pathways, reduces the levels of ROS, MDA and uric acid, elevates the levels of GPx, GSR, GST, SOD, CAT, HO-1 and GSH, scavenges free radicals and exerts reducing capacity. Azaleatin inhibits the expression of pro-apoptotic proteins Bax, Caspase-9 and Caspase-3, and upregulates the expression of anti-apoptotic protein Bcl-2. Azaleatin reduces the levels of cardiac injury markers, restores cardiac histological structure, inhibits Aβ aggregation, dengue protease activity, hepatic stellate cell proliferation and cancer cell growth, and also exhibits antibacterial activity. Azaleatin can be used in studies related to subchronic cardiotoxicity, Alzheimer's disease, dengue fever, hyperuricemia, liver fibrosis, gastric cancer and bacterial infections .
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Azaleatin-3-rutinoside
Azaleatin-3-rutinoside
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Cat. No.: HY-N12854
CAS No.: 63764-79-4
Category:  

other families Flavonoids Flavones Plants Casuarina equisetifolia L.

Target:  

Others

Azaleatin-3-rutinoside is a flavonol glycoside that can be isolated from Carya pecan .
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Azaleatin 3-O-galactoside
Azaleatin 3-O-galactoside
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Cat. No.: HY-N15175
CAS No.: 28454-85-5
Category:  

Flavonoids Leguminosae Flavones Plants Medicago × varia Martyn

Target:  

Drug Derivative

Azaleatin 3-O-galactoside (compound 11b) is a Quercetin (HY-18085) derivative with DPPH radical scavenging property. Azaleatin 3-O-galactoside can be used for antioxidant research .
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Azaleatin 3-glucoside
Azaleatin 3-glucoside
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Cat. No.: HY-N15178
CAS No.: 23598-17-6
Category:  

Flavonoids Juglandaceae Flavones Carya cathayensis Sarg. Plants

Target:  

Others

Azaleatin 3-glucoside is a flavonol glycoside that can be isolated from the branches of Carya pecan .
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