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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
BCATm
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "BCATm" in MCE Product Catalog:
6
6 Cited Publications
Research Areas:
BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6). BCAT-IN-2 can be used for the research of obesity and dislipidema .
1
1 Cited Publications
Cat. No.: HY-W017387
CAS No.: 4502-00-5
Synonyms: Sodium 4-methyl-2-oxopentanoate; 2-Ketoisocaproic acid sodium salt
Research Areas:
Sodium α-ketoisocaproate (Sodium 4-methyl-2-oxopentanoate) is an insulin secretagogue. Sodium α-ketoisocaproate undergoes transamination catalyzed by BCAT and BCATm to produce α-ketoglutarate and leucine; it also binds to the SUR1 site to inhibit KATP channel activity, but does not directly affect the Kir6.2 subunit. Sodium α-ketoisocaproate regulates Ca 2+ influx. Sodium α-ketoisocaproate exerts insulinotropic activity in pancreatic islets and intact mouse pancreata with sufficient BCATm expression. Sodium α-ketoisocaproate can be used in research related to type 2 diabetes .
Research Areas:
BCAT-IN-1 is a potent, selective and orally active inhibitor of BCATm, with a pIC50 of 7.3. BCAT-IN-1 shows 100-fold selectivity for BCATm over BCATc (pIC50=5.4). BCAT-IN-1 can be used for the research of metabolic diseases .
Cat. No.: HY-W017387S
CAS No.: 93523-67-2
Synonyms: Sodium 4-methyl-2-oxopentanoate-d3; 2-Ketoisocaproic acid-d3 sodium salt
Cat. No.: HY-RS01403
Target:
Research Areas:
BCAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for BCAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P701339
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BCAT2; Branched-chain-amino-acid aminotransferase; mitochondrial; BCAT(m); Placental protein 18; PP18
Cat. No.: HY-P701340
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BCAT2; Branched-chain-amino-acid aminotransferase; mitochondrial; BCAT(m); Placental protein 18; PP18
Cat. No.: HY-RS17299
Target:
Research Areas:
Bcat2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcat2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23754
Target:
Research Areas:
Bcat2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcat2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
