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BCAT-IN-1 

Cat. No.: HY-141668
Handling Instructions

BCAT-IN-1 is a potent, selective and orally active inhibitor of BCATm, with a pIC50 of 7.3. BCAT-IN-1 shows 100-fold selectivity for BCATm over BCATc (pIC50=5.4). BCAT-IN-1 can be used for the research of metabolic diseases.

For research use only. We do not sell to patients.

BCAT-IN-1 Chemical Structure

BCAT-IN-1 Chemical Structure

CAS No. : 2581243-32-3

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Description

BCAT-IN-1 is a potent, selective and orally active inhibitor of BCATm, with a pIC50 of 7.3. BCAT-IN-1 shows 100-fold selectivity for BCATm over BCATc (pIC50=5.4). BCAT-IN-1 can be used for the research of metabolic diseases[1].

IC50 & Target

pIC50: 7.3 (BCATm)[1]

In Vitro

BCAT-IN-1 (compound 8b) inhibits BCATm in human cells, with a pIC50 of 7.0[1].
BCAT-IN-1 inhibits mouse BCATm, with pIC50 of 5.9 in the cellular assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BCAT-IN-1 (compound 8b) (30-300 mg/kg; p.o.) increases the level of c BCAAs in an acute mouse model over an extended duration[1].
BCAT-IN-1 (5 mg/kg; p.o.) exhibits oral bioavailability (F=28%) and Cmax (1648 ng/mL) in mice[1].
BCAT-IN-1 (1 mg/kg; i.v.) exhibits half-life (t1/2=9.2 h) and clearance (Cl=4.0 mL/min/kg) in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

538.46

Formula

C₂₅H₂₄BrN₅O₂S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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BCAT-IN-1
Cat. No.:
HY-141668
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