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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
CCNK
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "CCNK" in MCE Product Catalog:
Target:
Research Areas:
HQ005 is a potent CCNK degrader with an DC50 value of 0.041 µM. HQ005 is a molecular-glue degrader that mediates interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation .
Cat. No.: HY-168555
CAS No.: 3053716-98-3
YJ1206 is an orally active selective CDK12/CDK13 PROTAC degrader. YJ1206 induces DNA damage and genomic instability, activates the AKT pathway, and triggers apoptosis. YJ1206 reduces tumor cell viability, inhibits tumor growth, and attenuates tumor cell dissemination. YJ1206 is applicable to research related to prostate cancer and high-grade serous tubo-ovarian cancer .
Cat. No.: HY-W181530
CAS No.: 790245-61-3
Research Areas:
NCT02 is a molecular glue degrader based on the E3 ubiquitin ligase DDB1 that targets CDK12 and its binding partner CCNK. NCT02 triggers the ubiquitination and proteasomal degradation of CCNK, thereby downregulating CDK12 protein levels and inhibiting its downstream signaling pathways. NCT02 can induce tumor cell apoptosis, arrest the cell cycle, and selectively inhibit the proliferation of colorectal cancer cells carrying TP53 defects or belonging to the consensus molecular subtype CMS4. NCT02 has the potential to inhibit tumor growth in in vitro and in vivo models .
Cat. No.: HY-179289
CAS No.: 3070379-34-6
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ZLY025 is a potent and orally active CCNK molecular glue degrader with an DC50 of 42.7 nM. ZLY025 exhibits broad-spectrum antiproliferative activity against various tumor cells with IC50 values ranging from 0.08 to 2.45 μM. ZLY025 can induce cells apoptosis and G1 phase arrest. ZLY025 can be used for the research of cancer, such as lung cancer .
Cat. No.: HY-168556
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Research Areas:
YJ9069 is a CDK12/CDK13 PROTAC degrader. YJ9069 induces proteasome-dependent degradation of CDK12 and CDK13, and inhibits serine 2 phosphorylation of RNA polymerase II (RNA polymerase II). YJ9069 triggers gene length-dependent transcription elongation defects, reduces the expression of DNA damage response genes, and induces DNA damage, cell cycle arrest and apoptosis. YJ9069 inhibits tumor growth in prostate cancer models. YJ9069 can be used for the research of prostate cancer, Ewing sarcoma and breast cancer .
Cat. No.: HY-RS02135
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CCNK Human Pre-designed siRNA Set A contains three designed siRNAs for CCNK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18467
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Ccnk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccnk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24948
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Ccnk Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccnk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P701374
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK9; CCNK; Cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; Cyclin-K
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Source:
Cat. No.: HY-P701375
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK9; CCNK; Cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; Cyclin-K
Species:
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Cat. No.: HY-P701360
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK12; CCNK; Cyclin-dependent kinase 12; Cdc2-related kinase; arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCDK12; Cyclin-K
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Source:
Cat. No.: HY-P701361
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK12; CCNK; Cyclin-dependent kinase 12; Cdc2-related kinase; arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCDK12; Cyclin-K
Species:
Source:
Cat. No.: HY-P706016
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CDK12; CCNK; Cyclin-dependent kinase 12; Cdc2-related kinase; arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCDK12; Cyclin-K
Species:
Source:
Cat. No.: HY-P702689
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK9; CCNK; Cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; Cyclin-K
Species:
Source:
Cat. No.: HY-P702690
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CDK9; CCNK; Cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; Cyclin-K
Species:
Source:
Cat. No.: HY-P702692
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK12; CCNK; Cyclin-dependent kinase 12; Cdc2-related kinase; arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCDK12; Cyclin-K
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Source:
Cat. No.: HY-P703002
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CPR4; CyclinK
Species:
Source:
Cat. No.: HY-P702886
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRK7; CRKRS; KIAA0904
Species:
Source:
Cat. No.: HY-P702885
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CRK7; CRKRS; KIAA0904
Species:
Source:
Cat. No.: HY-P702693
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK13; cyclin-dependent kinase 13; CDC2L5, cell division cycle 2 like 5 (cholinesterase related cell division controller); CDC2L; CHED; cholinesterase related cell division controller; KIAA1791; CDC2-related protein kinase 5; cell division protein kinase 13; cell division cycle 2-like protein kinase 5; cholinesterase-related cell division controller; CDC2L5; hCDK13; FLJ35215;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
