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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
CCNK
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "CCNK" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-W181530
CAS No.: 790245-61-3
Research Areas:
NCT02 is a molecular glue degrader based on the E3 ubiquitin ligase DDB1 that targets CDK12 and its binding partner CCNK. NCT02 triggers the ubiquitination and proteasomal degradation of CCNK, thereby downregulating CDK12 protein levels and inhibiting its downstream signaling pathways. NCT02 can induce tumor cell apoptosis, arrest the cell cycle, and selectively inhibit the proliferation of colorectal cancer cells carrying TP53 defects or belonging to the consensus molecular subtype CMS4. NCT02 has the potential to inhibit tumor growth in in vitro and in vivo models .
Target:
Research Areas:
HQ005 is a potent CCNK degrader with an DC50 value of 0.041 µM. HQ005 is a molecular-glue degrader that mediates interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation .
Cat. No.: HY-179289
CAS No.: 3070379-34-6
Target:
Research Areas:
ZLY025 is a potent and orally active CCNK molecular glue degrader with an DC50 of 42.7 nM. ZLY025 exhibits broad-spectrum antiproliferative activity against various tumor cells with IC50 values ranging from 0.08 to 2.45 μM. ZLY025 can induce cells apoptosis and G1 phase arrest. ZLY025 can be used for the research of cancer, such as lung cancer .
Cat. No.: HY-RS02135
Target:
Research Areas:
CCNK Human Pre-designed siRNA Set A contains three designed siRNAs for CCNK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18467
Target:
Research Areas:
Ccnk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccnk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24948
Target:
Research Areas:
Ccnk Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccnk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P701374
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK9; Tat-Associated Kinase Complex Catalytic Subunit; Prev. CDC2L4; Cyclin-Dependent Kinase 9 (CDC2-Related Kinase); TAK; Serine/Threonine Protein Kinase PITALRE; Cell Division Protein Kinase 9; Serine/Threonine-Protein Kinase PITALRE; Cyclin-Dependent K
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701375
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK9; Tat-Associated Kinase Complex Catalytic Subunit; Prev. CDC2L4; Cyclin-Dependent Kinase 9 (CDC2-Related Kinase); TAK; Serine/Threonine Protein Kinase PITALRE; Cell Division Protein Kinase 9; Serine/Threonine-Protein Kinase PITALRE; Cyclin-Dependent K
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703002
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CCNK; Cyclin-K; Cyclin K; IDDHDF; CPR4
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701361
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK12; KIAA0904; Prev. CRKRS; Cell Division Cycle 2-Related Protein Kinase 7; CRK7; CDC2-Related Protein Kinase 7; Cdc2-Related Kinase, Arginine/Serine-Rich; CDC2 Related Protein Kinase 7; Cell Division Protein Kinase 12; HCDK12; Cyclin-Dependent Kinase 1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701360
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK12; KIAA0904; Prev. CRKRS; Cell Division Cycle 2-Related Protein Kinase 7; CRK7; CDC2-Related Protein Kinase 7; Cdc2-Related Kinase, Arginine/Serine-Rich; CDC2 Related Protein Kinase 7; Cell Division Protein Kinase 12; HCDK12; Cyclin-Dependent Kinase 1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706016
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CDK12; KIAA0904; Prev. CRKRS; Cell Division Cycle 2-Related Protein Kinase 7; CRK7; CDC2-Related Protein Kinase 7; Cdc2-Related Kinase, Arginine/Serine-Rich; CDC2 Related Protein Kinase 7; Cell Division Protein Kinase 12; HCDK12; Cyclin-Dependent Kinase 1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P811691
Synonyms: CPR4, CCNK, Cyclin-K
Cat. No.: HY-P702689
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK9; Tat-Associated Kinase Complex Catalytic Subunit; Prev. CDC2L4; Cyclin-Dependent Kinase 9 (CDC2-Related Kinase); TAK; Serine/Threonine Protein Kinase PITALRE; Cell Division Protein Kinase 9; Serine/Threonine-Protein Kinase PITALRE; Cyclin-Dependent K
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702690
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CDK9; Tat-Associated Kinase Complex Catalytic Subunit; Prev. CDC2L4; Cyclin-Dependent Kinase 9 (CDC2-Related Kinase); TAK; Serine/Threonine Protein Kinase PITALRE; Cell Division Protein Kinase 9; Serine/Threonine-Protein Kinase PITALRE; Cyclin-Dependent K
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702692
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK12; KIAA0904; Prev. CRKRS; Cell Division Cycle 2-Related Protein Kinase 7; CRK7; CDC2-Related Protein Kinase 7; Cdc2-Related Kinase, Arginine/Serine-Rich; CDC2 Related Protein Kinase 7; Cell Division Protein Kinase 12; HCDK12; Cyclin-Dependent Kinase 1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702693
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK13; Cell Division Protein Kinase 13; Prev. CDC2L5; Cyclin-Dependent Kinase 13; CDC2L; HCDK13; CHED; Cell Division Cycle 2-Like 5 (Cholinesterase-Related Cell Division Controller); Cholinesterase-Related Cell Division Controller; Mitogen-Activated Prote
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702886
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK12; KIAA0904; Prev. CRKRS; Cell Division Cycle 2-Related Protein Kinase 7; CRK7; CDC2-Related Protein Kinase 7; Cdc2-Related Kinase, Arginine/Serine-Rich; CDC2 Related Protein Kinase 7; Cell Division Protein Kinase 12; HCDK12; Cyclin-Dependent Kinase 1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702885
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CDK12; KIAA0904; Prev. CRKRS; Cell Division Cycle 2-Related Protein Kinase 7; CRK7; CDC2-Related Protein Kinase 7; Cdc2-Related Kinase, Arginine/Serine-Rich; CDC2 Related Protein Kinase 7; Cell Division Protein Kinase 12; HCDK12; Cyclin-Dependent Kinase 1
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
