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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
CDK3
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "CDK3" in MCE Product Catalog:
3
3 Cited Publications
RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
3
3 Cited Publications
RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
2
Roniciclib is an orally bioavailable pan-cyclin dependent kinase (CDK) inhibitor, with IC50s of 5-25 nM for CDK1, CDK2, CDK3, CDK4, CDK7 and CDK9.
Cat. No.: HY-142686A
Purity: 96.65%
Target:
Research Areas:
SGK1-IN-3 hydrochloride (Compound 3a) is an ATP-competitive SGK1 inhibitor with an IC50 of <1 nM against hSGK1. SGK1-IN-3 hydrochloride blocks the activity of CDK family members. SGK1-IN-3 hydrochloride serves as a P-glycoprotein substrate. SGK1-IN-3 can be used for the research of osteoarthritis .
Cat. No.: HY-RS02380
Target:
Research Areas:
CDK3 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18915
Target:
Research Areas:
Cdk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-E70678
CDK3 is a major player driving retinoblastoma (Rb) phosphorylation during the G0/G1 transition and in the early G1 phase of the cell cycle. CDK3 interacts with various transcription factors involved in cell proliferation, differentiation, and transformation driven by the EGFR/Ras signaling pathway. CDK3/CycE1 Recombinant Human Active Protein Kinase is an ortholog of CDK3 .
Cat. No.: HY-151878
CAS No.: 3034210-97-1
Research Areas:
CDK7-IN-20 is a potent, selective and irreversible CDK7 (CDK) inhibitor with an IC50 value of 4 nM. CDK7-IN-20 displays >206-fold selectivity for CDK7 over CDK1, CDK2, CDK3, CDK5, CDK6, CDK9 and CDK12 . CDK7-IN-20 has the potential for autosomal dominant polycystic kidney disease (ADPKD) research .
Cat. No.: HY-E70677
CDK3 is a major player driving retinoblastoma (Rb) phosphorylation during the G0/G1 transition and in the early G1 phase of the cell cycle. CDK3 interacts with various transcription factors involved in cell proliferation, differentiation, and transformation driven by the EGFR/Ras signaling pathway. CDK3/CycC Recombinant Human Active Protein Kinase is an ortholog of CDK3 .
Cat. No.: HY-E70680
CDK3 is a major player driving retinoblastoma (Rb) phosphorylation during the G0/G1 transition and in the early G1 phase of the cell cycle. CDK3 interacts with various transcription factors involved in cell proliferation, differentiation, and transformation driven by the EGFR/Ras signaling pathway. CDK3/CycO Recombinant Human Active Protein Kinase is an ortholog of CDK3 .
Cat. No.: HY-E70679
CDK3 is a major player driving retinoblastoma (Rb) phosphorylation during the G0/G1 transition and in the early G1 phase of the cell cycle. CDK3 interacts with various transcription factors involved in cell proliferation, differentiation, and transformation driven by the EGFR/Ras signaling pathway. CDK3/CycE2 Recombinant Human Active Protein Kinase is an ortholog of CDK3 .
Cat. No.: HY-161708
CAS No.: 3075001-08-7
PROTAC FLT3/CDKs degrader-1 (Compound C3) is a degrader for cyclin-dependent kinases (DC50 is 18.73 nM for CDK2) and the FMS-like tyrosine kinase 3 (FLT3). PROTAC FLT3/CDKs degrader-1 induces differentation of HL-60 (72.77% differentation at 6.25 nM), inhibits proliferation of AML cells, with IC50s of 2.9-37 nM. PROTAC FLT3/CDKs degrader-1 is potential for ameliorating acute myeloid leukemia. (Pink: ligand for target protein FLT3/CDKs ligand-1 (HY-161709); Black: linker (HY-W012935); Black: ligand for E3 ligase Thalidomide 5-fluoride (HY-W087383))
Cat. No.: HY-P703553
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CDKN3
Species:
Source:
Cat. No.: HY-P701364
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK3; CCNE1; Cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1
Species:
Source:
Cat. No.: HY-P702680
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CDK3; CCNE1; Cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1
Species:
Source:
Cat. No.: HY-P702681
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK3; CCNE1; Cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1
Species:
Source:
Cat. No.: HY-P701365
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK3; CCNE1; Cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1
Species:
Source:
Cat. No.: HY-161709
CAS No.: 2452019-67-7
Research Areas:
FLT3/CDKs ligand-1 (Compound 14) is a ligand for target protein, which promotes the degradation of cyclin-dependent kinase (CDK) and the FMS-like tyrosine kinase 3 (FLT3), inhibits FLT3/CDK related proliferations and survivals of leukemia cells. LT3/CDKs ligand-1 can be used for synthesis of PROTAC FLT3/CDKs degrader-1 (HY-161708) .
Cat. No.: HY-P706030
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Cyclin-dependent kinase 3; Cell division protein kinase 3; CDKN3; Cyclin-H; MO15-associated protein; p34; p37
Species:
Source:
Cat. No.: HY-P810605
Synonyms: CDK2; CDKN2; Cyclin-dependent kinase 2; Cell division protein kinase 2; p33 protein kinase
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
