CHIP

By Targets:	Apoptosis (1) Aryl Hydrocarbon Receptor (1) Bcl-2 Family (1) Biochemical Assay Reagents (6) c-Myc (2) Caspase (1) Endogenous Metabolite (1) Environmental Pollutants (1) Fluorescent Dye (1) Histone Methyltransferase (1) IAP (1) Isotope-Labeled Compounds (1) Ligands for E3 Ligase (1) Molecular Glues (1) NF-κB (1) Small Interfering RNA (siRNA) (3) STAT (1) Survivin (1) Tau Protein (1) VEGFR (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145898

WBC100 14-D-Valine-TPL	c-Myc Molecular Glues	Cancer
WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc molecule glue degrader. WBC100 is a c-Myc degrader and targets ubiquitin E3 ligase CHIP mediated 26S proteasome pathway. WBC100 is used for c-Myc overexpressing tumors research .

HY-W763582B

GelMA, 90% methacrylation Gelatin Methacryloyl, 90% methacrylation	Biochemical Assay Reagents	Others
GelMA (Gelatin Methacryloyl), 90% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing .

HY-W763582

GelMA, 30% methacrylation Gelatin Methacryloyl, 30% methacrylation	Biochemical Assay Reagents	Others
GelMA (Gelatin Methacryloyl), 30% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing .

HY-175552

CHIPOpt	Tau Protein	Neurological Disease
CHIPOpt, a peptide, is an orthosteric CHIP TPR domain inhibitor with a K_d of ∼16 nM. CHIPOpt has anti-aggregation activity and decreases p.tau ubiquitination with little effect on unmodified tau. CHIPOpt can be used for Alzheimer’s disease research .

HY-18619

YL-109 2 Publications Verification	Aryl Hydrocarbon Receptor	Cancer
YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. YL-109 has ability to inhibit breast cancer cell growth and invasiveness .

HY-175686

E3 ligase Ligand 67	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 67 (Compound 5) is a *STUB1/CHIP* ligand with a K_d of 8.9  μM for CHIP in fluorescence polarization assay. E3 ligase Ligand 67 is an E3 ligase ligand that can be used for synthesis of PROTACs .

HY-W123005

Dimethyl pimelimidate dihydrochloride 1 Publications Verification	Biochemical Assay Reagents	Others
Dimethyl pimelimidate dihydrochloride is a bifunctional imidoester protein-protein crosslinker used in chromatin immunoprecipitation (ChIP) assays .

HY-W763582A

GelMA, 60% methacrylation Gelatin Methacryloyl, 60% methacrylation	Biochemical Assay Reagents	Others
GelMA (Gelatin Methacryloyl), 60% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing .

HY-101508

GNA002	Histone Methyltransferase	Cancer
GNA002 is a highly potent, specific and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor with an IC₅₀ of 1.1 μM. GNA002 can specifically and covalently bind to Cys668 within the EZH2-SET domain, triggering EZH2 degradation through COOH terminus of Hsp70-interacting protein (CHIP)-mediated ubiquitination. GNA002 efficiently reduces EZH2-mediated H3K27 trimethylation, reactivates polycomb repressor complex 2 (PRC2)-silenced tumor suppressor genes .

HY-W391506

Poly(methyl methacrylate) Poly(methyl methacrylate), beads; PMMA	Environmental Pollutants Endogenous Metabolite Biochemical Assay Reagents	Others
Poly(methyl methacrylate) (PMMA) serves as an effective material for the production of micro-fluidic chips.

HY-N3001

Isolinderalactone 1 Publications Verification	STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase	Neurological Disease Inflammation/Immunology Cancer
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .

HY-RS13972

STUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for STUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STUB1 Human Pre-designed siRNA Set A STUB1 Human Pre-designed siRNA Set A

HY-D1721

Fluorescein-12-dATP	Fluorescent Dye	Others
Fluorescein-12-dATP is a fluorescent dye acting as the detection probe. Fluorescein-12-dATP can be used to label the thrombin-binding aptamers by catalytic polymerization of TdT (terminal deoxynucleotidyl transferase) . Fluorescein-12-dATP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151884

FUBP1-IN-2	c-Myc	Cancer
FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines .

HY-130071

Iproplatin CHIP	Biochemical Assay Reagents	Cardiovascular Disease Metabolic Disease Cancer
Iproplatin (CHIP) is an anti-cancer agent with reduced toxicity in testicular and ovarian cancers. The major reduced product of Iproplatin by glutathione is chloro-bis (isopropylamine) glutathionatoplatinum (II). Iproplatin is promising for research of Thrombocytopenia and a wide range of cancers .

HY-W771025

1,4-Diiodobutane-13C4 Tetramethylene Iodide (stabilized with Copper CHIP)-13C4	Isotope-Labeled Compounds	Others
1,4-Diiodobutane- ¹³C₄ (Tetramethylene Iodide (stabilized with Copper chip)- ¹³C₄) is the ¹³C-labeled 1,4-Diiodobutane (HY-W004871).

HY-RS17083

Stub1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stub1 Mouse Pre-designed siRNA Set A Stub1 Mouse Pre-designed siRNA Set A

HY-RS23527

Stub1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stub1 Rat Pre-designed siRNA Set A Stub1 Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-W763582B

GelMA, 90% methacrylation Gelatin Methacryloyl, 90% methacrylation	Biochemical Assay Reagents
GelMA (Gelatin Methacryloyl), 90% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing .

GelMA, 90% methacrylation

Gelatin Methacryloyl, 90% methacrylation

Biochemical Assay Reagents

GelMA (Gelatin Methacryloyl), 90% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing .

HY-W763582

GelMA, 30% methacrylation Gelatin Methacryloyl, 30% methacrylation	Biochemical Assay Reagents
GelMA (Gelatin Methacryloyl), 30% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing .

GelMA, 30% methacrylation

Gelatin Methacryloyl, 30% methacrylation

Biochemical Assay Reagents

GelMA (Gelatin Methacryloyl), 30% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing .

HY-W763582A

GelMA, 60% methacrylation Gelatin Methacryloyl, 60% methacrylation	Biochemical Assay Reagents
GelMA (Gelatin Methacryloyl), 60% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing .

GelMA, 60% methacrylation

Gelatin Methacryloyl, 60% methacrylation

Biochemical Assay Reagents

GelMA (Gelatin Methacryloyl), 60% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing .

Cat. No.	Product Name	Target	Research Area

HY-175552

CHIPOpt	Tau Protein	Neurological Disease
CHIPOpt, a peptide, is an orthosteric CHIP TPR domain inhibitor with a K_d of ∼16 nM. CHIPOpt has anti-aggregation activity and decreases p.tau ubiquitination with little effect on unmodified tau. CHIPOpt can be used for Alzheimer’s disease research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3001

Isolinderalactone 1 Publications Verification	Classification of Application Fields Terpenoids Sesquiterpenes Plants Lauraceae Lindera aggregata (Sims) Kosterm. Disease Research Fields Source Classification Cancer	STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .

Species:	Human (4)
Tag:	SUMO (1) His (2) Tag Free (1) GST (1)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71340

	STUB1 Protein, Human 2 Publications Verification E3 Ubiquitin-Protein Ligase CHIP; Antigen NY-CO-7; CLL-Associated Antigen KW-8; Carboxy Terminus of Hsp70-Interacting Protein; STIP1 Homology and U Box-Containing Protein 1; STUB1; CHIP	Human	E. coli
	STUB1 protein is an E3 ubiquitin protein ligase that cooperates with ATXN3 to regulate ubiquitin chain length on substrates and prevent chain extension. It ubiquitinates NOS1 through Hsp70/Hsp40 and regulates chaperone complexes (Hsp70, Hsc70, Hsp90). STUB1 Protein, Human is the recombinant human-derived STUB1 protein, expressed by E. coli , with tag free.

HY-P705928

	STUB1 Protein, Human (His) E3 Ubiquitin-Protein Ligase CHIP; Antigen NY-CO-7; CLL-Associated Antigen KW-8; Carboxy Terminus of Hsp70-Interacting Protein; STIP1 Homology and U Box-Containing Protein 1; STUB1; CHIP	Human	E. coli
	STUB1 protein is an E3 ubiquitin protein ligase that cooperates with ATXN3 to regulate ubiquitin chain length on substrates and prevent chain extension. It ubiquitinates NOS1 through Hsp70/Hsp40 and regulates chaperone complexes (Hsp70, Hsc70, Hsp90). STUB1 Protein, Human (His) is the recombinant human-derived STUB1 protein, expressed by E. coli , with His tag.

HY-P72085

	AQP1 Protein, Human (His-SUMO) AQP 1; AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; aquaporin 1 channel-forming integral protein; 28kDa; CO blood group; ; aquaporin 1 Colton blood group; ; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel forming integral protein 28kDa; Channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; CO; Colton blood group; Growth factor induced delayed early response protein; MGC26324; Urine water channel; Water channel protein CHIP 29; Water channel protein CHIP29; Water channel protein for red blood cells and kidney proximal tubule	Human	E. coli
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (His-SUMO) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P72086

	AQP1 Protein, Human (GST) AQP 1; AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; aquaporin 1 channel-forming integral protein; 28kDa; CO blood group; ; aquaporin 1 Colton blood group; ; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel forming integral protein 28kDa; Channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; CO;	Human	E. coli
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (GST) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-GST labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W771025

1,4-Diiodobutane-13C4
1,4-Diiodobutane- ¹³C₄ (Tetramethylene Iodide (stabilized with Copper chip)- ¹³C₄) is the ¹³C-labeled 1,4-Diiodobutane (HY-W004871).

Host:	Rabbit (4)
Reactivity:	Human (4) Rat (2) Mouse (2)
Application:	IHC-P (3) ICC/IF (1) IF-Tissue (1) IP (1) IHC-F (1) WB (2)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82351

	STUB1 Antibody (YA2096) STUB1; CHIP; HSPABP2; NY-CO-7; SDCCAG7; UBOX1	WB, ICC/IF, IP	Human, Mouse, Rat
	STUB1 Antibody (YA2096) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STUB1.

HY-P86699

	Aquaporin 1 Antibody (YA6391) AQP 1; AQP-1; AQP1_HUMAN; Aquaporin-1; Aquaporin-CHIP; Channel like integral membrane protein 28 kDa; MGC26324; Water channel protein CHIP 29; AQP CHIP; AQP1; Aquaporin CHIP; Aquaporin1; Aquaporin 1; Channel forming integral protein 28kDa; CHIP 28; CHIP28; CO; Colton blood group; Growth factor induced delayed early response protein; Urine water channel; Water channel protein CHIP29; Water channel protein for red blood cells and kidney proximal tubule.	WB, IF-Tissue, IHC-P, IHC-F	Human, Mouse, Rat
	Aquaporin 1 Antibody (YA6391) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 1.

HY-P81404

	Aquaporin 1 Antibody (YA1149) AQP1; CHIP28; Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule	IHC-P	Human
	Aquaporin 1 Antibody (YA1149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 1.

HY-P81404A

	Aquaporin 1 Antibody (YA1149)(PBS only) AQP1; CHIP28; Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule	IHC-P	Human
	Aquaporin 1 Antibody (YA1149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 1.

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Cat. No.	Product Name		Classification

HY-RS13972

STUB1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
STUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for STUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17083

Stub1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Stub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23527

Stub1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Stub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Inhibitors & Agonists

Biochemical Assay Reagents

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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

CHIP

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
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