GelMA, 90% methacrylation  (Synonyms: Gelatin Methacryloyl, 90% methacrylation)

GelMA (Gelatin Methacryloyl), 90% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing^[1].

GelMA, 90% methacrylation can be photocrosslinked with the photoinitiator LAP (HY-44076) to form a hydrogel that functions as a bioactive and biodegradable scaffold, providing structural support and cell-adhesion motifs for tissue cells^[1].
GelMA, 90% methacrylation can be formulated into hydrogels incorporated with chitosan microspheres (CM-SIN) for application in osteoarthritis research^[2].
GelMA, 90% methacrylation can be combined with poly(lactic-co-glycolic acid) (PLGA) (HY-B2247) microparticles to fabricate a composite microparticle system for drug delivery^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GelMA, 90% methacrylation can be photocrosslinked into hydrogels that can promote both cutaneous tissue formation within two weeks and vascularization in a rat full-thickness wound model, thereby alleviating distal necrosis of random-pattern skin flaps^[4][5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2280018-77-9

Solid

White to off-white

[GelMA, 90% methacrylation]

Room temperature in continental US; may vary elsewhere.

• [1]. Piao Y, et al., Biomedical applications of gelatin methacryloyl hydrogels[J]. Engineered Regeneration, 2021, 2: 47-56.

  [2]. Chen P, et al. Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy. Biomaterials. 2016 Mar;81:1-13.  [Content Brief]

  [3]. Y. Li, et al. Composite core-shell microparticles from microfluidics for synergistic drug delivery. Sci. China Mater., 60 (6) (2017), pp. 543-553.

  [4]. Zhao X, et al. Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing. Biomaterials. 2017 Apr;122:34-47.  [Content Brief]

  [5]. X. Sun, et al. Electrospun photocrosslinkable hydrogel fibrous scaffolds for rapid in vivo vascularized skin flap regeneration. Adv. Funct. Mater., 27 (2) (2017).