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Results for "

CLDN18

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (3) CD3 (4) CD47 (1) Claudin (12) Small Interfering RNA (siRNA) (3) TNF Receptor (1)
By Research Areas:	Cancer (14) Inflammation/Immunology (6)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99350

Gresonitamab 1 Publications Verification AMG 910; Anti-Human CD3xClaudin18 2	CD3	Cancer
Gresonitamab (AMG 910) is a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody targets CD3-positive T cells and *CLDN18.2*-expressing tumor cells. Gresonitamab can be used for the research of adenocarcinoma .

HY-P991564

Arcotatug IBI-343 antibody; HB37A6; TAK-921 Antibody	ADC Antibody Claudin	Cancer
Arcotatug (IBI-343 antibody) is a *CLDN18.2* targeting humanized monoclonal antibody. Arcotatug can be used for synthesis of ADCs .

HY-P990742

Givastomig TJ-CD4B; ABL111; TJ033721	TNF Receptor Claudin	Inflammation/Immunology Cancer
Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma .

HY-P991163

Tixentamig	CD3 Claudin	Cancer
Tixentamig is a bispecific monoclonal antibody targeting human CD3 ε and *CLDN18* (claudin 18). Tixentamig is promising for research of cancers .

HY-P991681

Emaretamig ASP-2138	Claudin CD3	Cancer
Emaretamig is a humanized IgG1κ monoclonal antibody inhibitor targeting *CLDN18* and CD3E. Abdakibart can be used for cancers like gastric and pancreatic cancer research .

HY-RS02768

CLDN18 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CLDN18 Human Pre-designed siRNA Set A contains three designed siRNAs for CLDN18 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CLDN18 Human Pre-designed siRNA Set A CLDN18 Human Pre-designed siRNA Set A

HY-P991700

Lumivatamig	Claudin CD3	Cancer
Lumivatamig is an H-γ1_L-κ-scFvhl dimer-type bispecific antibody targeting CLDN18.2 & CD3E .

HY-RS25188

Cldn18 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cldn18 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cldn18 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cldn18 Rat Pre-designed siRNA Set A Cldn18 Rat Pre-designed siRNA Set A

HY-RS18701

Cldn18 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cldn18 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cldn18 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cldn18 Mouse Pre-designed siRNA Set A Cldn18 Mouse Pre-designed siRNA Set A

HY-P991027

Spevatamig PT-886	CD47	Inflammation/Immunology
HY-P991027 is an *CD47/CLDN18*-targeting (H-γ1_L-κ)_(H-γ1_L-κ) type bispecific antibody .

HY-P991140

Garetatug	Claudin	Cancer
Garetatug is a humanized monoclonal antibody targeting human *CLDN18* (claudin-18). Garetatug specifically binds to *CLDN18*, interfering with relevant cell signaling pathways and exerting antitumor activity .

HY-P991687

Gaspantatug	Claudin	Cancer
Gaspantatug is a humanized IgG1κ antibody targeting *CLDN18.2*. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991679

Elatatug TORL-2-307 antibody	Claudin	Cancer
Elatatug is an anti-CLDN18 (claudin 18) IgG1κ type humanized antibody with antineoplastic activity. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992467

SOT102 Antibody	ADC Antibody	Cancer
SOT102 Antibody is an IgG1 monoclonal antibody targeting *CLDN18.2. SOT102 Antibody binds selectively to CLDN18.2*, and promotes internalization. SOT102 Antibody can be used for the research of cancer ^[2]^.

HY-P992508

SPX-101 SX001	Claudin	Cancer
SPX-101 (SX001) is a humanized monoclonal antibody targeting *CLDN18.2. CLDN18*.2 is only transiently expressed in the differentiated epithelial cells of the gastric mucosa and is hardly found in healthy tissues, thus having an extremely wide therapeutic window. SPX-101 can be used for the study of solid tumors.

HY-P992355

GB7004-09 GB7004-09hu15	Claudin	Cancer
GB7004-09 (GB7004-09hu15) is a humanized monoclonal antibody against *CLDN18.2*. GB7004-09 can be used in cancer research .

HY-P992412

MIL93	Claudin	Cancer
MIL93 is a humanized defucosylated IgG1 monoclonal antibody targeting *Claudin18.2* (CLDN18.2) with enhanced antibody-dependent cellular cytotoxicity (ADCC) activity. MIL93 can be used for research on advanced solid tumors and gastric cancer. The recommended isotype control is human IgG1 kappa (HY-P99001) .

HY-P992316

ATG-022 Antibody	Claudin ADC Antibody	Cancer
ATG-022 Antibody is a humanized monoclonal antibody targeting Claudin 18.2 (CLDN 18.2). ATG-022 Antibody binds with VcMMAE (HY-15575) to form an Antibody-Drug Conjugate (ADC). ATG-022 Antibody can be used for the research of advanced/metastatic solid tumors and gastric cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99350

Gresonitamab 1 Publications Verification AMG 910; Anti-Human CD3xClaudin18 2	CD3	Cancer
Gresonitamab (AMG 910) is a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody targets CD3-positive T cells and *CLDN18.2*-expressing tumor cells. Gresonitamab can be used for the research of adenocarcinoma .

HY-P991564

Arcotatug IBI-343 antibody; HB37A6; TAK-921 Antibody	ADC Antibody Claudin	Cancer
Arcotatug (IBI-343 antibody) is a *CLDN18.2* targeting humanized monoclonal antibody. Arcotatug can be used for synthesis of ADCs .

HY-P990742

Givastomig TJ-CD4B; ABL111; TJ033721	TNF Receptor Claudin	Inflammation/Immunology Cancer
Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma .

HY-P991163

Tixentamig	CD3 Claudin	Cancer
Tixentamig is a bispecific monoclonal antibody targeting human CD3 ε and *CLDN18* (claudin 18). Tixentamig is promising for research of cancers .

HY-P991681

Emaretamig ASP-2138	Claudin CD3	Cancer
Emaretamig is a humanized IgG1κ monoclonal antibody inhibitor targeting *CLDN18* and CD3E. Abdakibart can be used for cancers like gastric and pancreatic cancer research .

HY-P990946

Tecotabart LM-102	Inhibitory Antibodies	Inflammation/Immunology
HY-P990946 is an *CLDN18*-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991026

Sonesitatug	Inhibitory Antibodies	Inflammation/Immunology
HY-P991026 is an *CLDN18*-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991700

Lumivatamig	Claudin CD3	Cancer
Lumivatamig is an H-γ1_L-κ-scFvhl dimer-type bispecific antibody targeting CLDN18.2 & CD3E .

HY-P991027

Spevatamig PT-886	CD47	Inflammation/Immunology
HY-P991027 is an *CD47/CLDN18*-targeting (H-γ1_L-κ)_(H-γ1_L-κ) type bispecific antibody .

HY-P991140

Garetatug	Claudin	Cancer
Garetatug is a humanized monoclonal antibody targeting human *CLDN18* (claudin-18). Garetatug specifically binds to *CLDN18*, interfering with relevant cell signaling pathways and exerting antitumor activity .

HY-P991687

Gaspantatug	Claudin	Cancer
Gaspantatug is a humanized IgG1κ antibody targeting *CLDN18.2*. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991679

Elatatug TORL-2-307 antibody	Claudin	Cancer
Elatatug is an anti-CLDN18 (claudin 18) IgG1κ type humanized antibody with antineoplastic activity. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992467

SOT102 Antibody	ADC Antibody	Cancer
SOT102 Antibody is an IgG1 monoclonal antibody targeting *CLDN18.2. SOT102 Antibody binds selectively to CLDN18.2*, and promotes internalization. SOT102 Antibody can be used for the research of cancer ^[2]^.

HY-P992508

SPX-101 SX001	Claudin	Cancer
SPX-101 (SX001) is a humanized monoclonal antibody targeting *CLDN18.2. CLDN18*.2 is only transiently expressed in the differentiated epithelial cells of the gastric mucosa and is hardly found in healthy tissues, thus having an extremely wide therapeutic window. SPX-101 can be used for the study of solid tumors.

HY-P991013

Omectatug ASKB-589	Inhibitory Antibodies	Inflammation/Immunology
HY-P991013 is an *CLDN18*-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990979

Ciletatug RC118 Antibody	Inhibitory Antibodies	Inflammation/Immunology
HY-P990979 is an *CLDN18*-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992355

GB7004-09 GB7004-09hu15	Claudin	Cancer
GB7004-09 (GB7004-09hu15) is a humanized monoclonal antibody against *CLDN18.2*. GB7004-09 can be used in cancer research .

HY-P992412

MIL93	Claudin	Cancer
MIL93 is a humanized defucosylated IgG1 monoclonal antibody targeting *Claudin18.2* (CLDN18.2) with enhanced antibody-dependent cellular cytotoxicity (ADCC) activity. MIL93 can be used for research on advanced solid tumors and gastric cancer. The recommended isotype control is human IgG1 kappa (HY-P99001) .

HY-P992316

ATG-022 Antibody	Claudin ADC Antibody	Cancer
ATG-022 Antibody is a humanized monoclonal antibody targeting Claudin 18.2 (CLDN 18.2). ATG-022 Antibody binds with VcMMAE (HY-15575) to form an Antibody-Drug Conjugate (ADC). ATG-022 Antibody can be used for the research of advanced/metastatic solid tumors and gastric cancer .

Species:	Human (10) Mouse (1) Cynomolgus (1)
Tag:	mCherry (1) His (8) Strep (1) Tag Free (2) Avi (1) Flag (1)
Source:	HEK293 (8) sf9 insect cells (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70701

	*Claudin-18/CLDN18.2 Protein, Human (His)* Claudin-18; CLDN18	Human	E. coli
	CLDN18 play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. Claudin-18/CLDN18.2 Protein, Human (His) is the recombinant human-derived Claudin-18/CLDN18.2 protein, expressed by E. coli , with N-8*His labeled tag. The complete sequence length is 172 amino acids. In addition to the target fragment P56856-2 (D28-L76), there are other fusion sequences that play a role in stabilizing the extracellular region.

HY-P70045

	*Claudin-18/CLDN18.1 Protein, Human (His)* rHuClaudin-18/CLDN18, His; Claudin-18; CLDN18	Human	E. coli
	CLDN18 play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. Claudin-18/CLDN18.1 Protein, Human (His) is the recombinant human-derived Claudin-18/CLDN18.1 protein, expressed by E. coli , with N-8*His labeled tag. The complete sequence length is 171 amino acids. In addition to the target fragment P56856-1 (D28-L76), there are other fusion sequences that play a role in stabilizing the extracellular region.

HY-P700404

	*Claudin-18/CLDN18.2 Protein-VLP, Mouse (HEK293, His)* rHuClaudin-18/CLDN18, His; Claudin-18; CLDN18	Mouse	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Mouse (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P704502

	*Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, GFP)* CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, GFP) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

HY-P78368

	*Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293)* CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293) is recommended for SPR analysis, animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P700403

	*Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, His)* CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P78105

	*Claudin-18/CLDN18.2 Protein-VLP, Human (Biotinylated, HEK293)* CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (Biotinylated, HEK293) is recommended only for SPR analysis. HY-P78368 can be used in animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P700440

	*Claudin-18/CLDN18.2 Protein-VLP, Cynomolgus (HEK293, His)* CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Cynomolgus	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Cynomolgus (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P704504

	*Claudin-18/CLDN18.2 Protein-Nanodisc, Human (sf9, Twin Strep)* CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	sf9 insect cells
	CLDN18-VLPs (Claudin 18 virus-like particles) play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. Claudin-18/CLDN18.2 Protein-Nanodisc, Human (sf9, Twin Strep) is the recombinant human-derived Claudin-18/CLDN18.2 protein, expressed by sf9 insect cells, with C-Twin-Strep and N-His labeled tag.

HY-P705008

	*Claudin-18/CLDN18.2 Protein-Nanodisc, Human (Biotinylated, sf9, Flag, His-Avi)* CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	sf9 insect cells

HY-P705964

	*Claudin-18/CLDN18.2 Protein, Human (HEK293, His, Detergent)* CLDN18.2	Human	HEK293
	As a membrane protein, Claudin-18/CLDN18.2 requires a detergent system to maintain its solubility and biological activity. The designated system consists of 10% (w/v) DDM and 2% (w/v) CHS, both of which are essential components for preserving protein stability and function. Under no circumstances should these detergents be removed.

HY-P702247

	*Claudin-18/CLDN18.1 Protein-VLP, Human (HEK293, mCherry)* Claudin-18	Human	HEK293
	Claudin-18/CLDN18.1 Protein-VLP, Human (HEK293, mCherry) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

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Host:	Mouse (1) Rabbit (1)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) WB (1) FC (1) ELISA (1)
Isotype:	IgG (1) IgG1 (1)
Conjugation:	Non-conjugated (2) Biotin (2)
Clonality:	Polyclonal (1) Monoclonal (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85991

	Claudin 18.1 Antibody (YA5683) Claudin 18 antibody; Claudin-18 antibody; CLD18_HUMAN antibody; CLDN18 antibody; SFTA5 antibody; SFTPJ antibody;	IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Claudin 18.1 Antibody (YA5683) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Claudin 18.1.

HY-P81773

	Claudin 18.2 Antibody CLDN 18.2,Claudin 18.2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Claudin 18.2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Claudin 18.2.

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