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Results for "

CLDN18.2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (3) CD3 (2) Claudin (8) TNF Receptor (1)
By Research Areas:	Cancer (10) Inflammation/Immunology (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P991564

Arcotatug IBI-343 antibody; HB37A6; TAK-921 Antibody	ADC Antibody Claudin	Cancer
Arcotatug (IBI-343 antibody) is a *CLDN18.2* targeting humanized monoclonal antibody. Arcotatug can be used for synthesis of ADCs .

HY-P99350

Gresonitamab 1 Publications Verification AMG 910; Anti-Human CD3xClaudin18 2	CD3	Cancer
Gresonitamab (AMG 910) is a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody targets CD3-positive T cells and *CLDN18.2*-expressing tumor cells. Gresonitamab can be used for the research of adenocarcinoma .

HY-P990742

Givastomig TJ-CD4B; ABL111; TJ033721	TNF Receptor Claudin	Inflammation/Immunology Cancer
Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to **Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9)** on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma .

HY-P991700

Lumivatamig	Claudin CD3	Cancer
Lumivatamig is an H-γ1_L-κ-scFvhl dimer-type bispecific antibody targeting CLDN18.2 & CD3E .

HY-P991687

Gaspantatug	Claudin	Cancer
Gaspantatug is a humanized IgG1κ antibody targeting *CLDN18.2*. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992467

SOT102 Antibody	ADC Antibody	Cancer
SOT102 Antibody is an IgG1 monoclonal antibody targeting *CLDN18.2. SOT102 Antibody binds selectively to CLDN18.2*, and promotes internalization. SOT102 Antibody can be used for the research of cancer ^[2]^.

HY-P992508

SPX-101 SX001	Claudin	Cancer
SPX-101 (SX001) is a humanized monoclonal antibody targeting *CLDN18.2. CLDN18.2* is only transiently expressed in the differentiated epithelial cells of the gastric mucosa and is hardly found in healthy tissues, thus having an extremely wide therapeutic window. SPX-101 can be used for the study of solid tumors.

HY-P992412

MIL93	Claudin	Cancer
MIL93 is a humanized defucosylated IgG1 monoclonal antibody targeting *Claudin18.2* (CLDN18.2) with enhanced antibody-dependent cellular cytotoxicity (ADCC) activity. MIL93 can be used for research on advanced solid tumors and gastric cancer. The recommended isotype control is human IgG1 kappa (HY-P99001) .

HY-P992355

GB7004-09 GB7004-09hu15	Claudin	Cancer
GB7004-09 (GB7004-09hu15) is a humanized monoclonal antibody against *CLDN18.2*. GB7004-09 can be used in cancer research .

HY-P992316

ATG-022 Antibody	Claudin ADC Antibody	Cancer
ATG-022 Antibody is a humanized monoclonal antibody targeting Claudin 18.2 (CLDN 18.2). ATG-022 Antibody binds with VcMMAE (HY-15575) to form an Antibody-Drug Conjugate (ADC). ATG-022 Antibody can be used for the research of advanced/metastatic solid tumors and gastric cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991564

Arcotatug IBI-343 antibody; HB37A6; TAK-921 Antibody	ADC Antibody Claudin	Cancer
Arcotatug (IBI-343 antibody) is a *CLDN18.2* targeting humanized monoclonal antibody. Arcotatug can be used for synthesis of ADCs .

HY-P99350

Gresonitamab 1 Publications Verification AMG 910; Anti-Human CD3xClaudin18 2	CD3	Cancer
Gresonitamab (AMG 910) is a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody targets CD3-positive T cells and *CLDN18.2*-expressing tumor cells. Gresonitamab can be used for the research of adenocarcinoma .

HY-P990742

Givastomig TJ-CD4B; ABL111; TJ033721	TNF Receptor Claudin	Inflammation/Immunology Cancer
Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to **Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9)** on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma .

HY-P991700

Lumivatamig	Claudin CD3	Cancer
Lumivatamig is an H-γ1_L-κ-scFvhl dimer-type bispecific antibody targeting CLDN18.2 & CD3E .

HY-P991687

Gaspantatug	Claudin	Cancer
Gaspantatug is a humanized IgG1κ antibody targeting *CLDN18.2*. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992467

SOT102 Antibody	ADC Antibody	Cancer
SOT102 Antibody is an IgG1 monoclonal antibody targeting *CLDN18.2. SOT102 Antibody binds selectively to CLDN18.2*, and promotes internalization. SOT102 Antibody can be used for the research of cancer ^[2]^.

HY-P992508

SPX-101 SX001	Claudin	Cancer
SPX-101 (SX001) is a humanized monoclonal antibody targeting *CLDN18.2. CLDN18.2* is only transiently expressed in the differentiated epithelial cells of the gastric mucosa and is hardly found in healthy tissues, thus having an extremely wide therapeutic window. SPX-101 can be used for the study of solid tumors.

HY-P992412

MIL93	Claudin	Cancer
MIL93 is a humanized defucosylated IgG1 monoclonal antibody targeting *Claudin18.2* (CLDN18.2) with enhanced antibody-dependent cellular cytotoxicity (ADCC) activity. MIL93 can be used for research on advanced solid tumors and gastric cancer. The recommended isotype control is human IgG1 kappa (HY-P99001) .

HY-P992355

GB7004-09 GB7004-09hu15	Claudin	Cancer
GB7004-09 (GB7004-09hu15) is a humanized monoclonal antibody against *CLDN18.2*. GB7004-09 can be used in cancer research .

HY-P992316

ATG-022 Antibody	Claudin ADC Antibody	Cancer
ATG-022 Antibody is a humanized monoclonal antibody targeting Claudin 18.2 (CLDN 18.2). ATG-022 Antibody binds with VcMMAE (HY-15575) to form an Antibody-Drug Conjugate (ADC). ATG-022 Antibody can be used for the research of advanced/metastatic solid tumors and gastric cancer .

Species:	Human (8) Mouse (1) Cynomolgus (1)
Tag:	His (7) Strep (1) Tag Free (2) Avi (1) Flag (1)
Source:	HEK293 (7) sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705964

	*Claudin-18/CLDN18.2* Protein, Human (HEK293, His, Detergent)** CLDN18.2	Human	HEK293
	As a membrane protein, Claudin-18/CLDN18.2 requires a detergent system to maintain its solubility and biological activity. The designated system consists of 10% (w/v) DDM and 2% (w/v) CHS, both of which are essential components for preserving protein stability and function. Under no circumstances should these detergents be removed.

HY-P704502

	*Claudin-18/CLDN18.2* Protein-VLP, Human (HEK293, GFP)** CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, GFP) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

HY-P78368

	*Claudin-18/CLDN18.2* Protein-VLP, Human (HEK293)** CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293) is recommended for SPR analysis, animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P700403

	*Claudin-18/CLDN18.2* Protein-VLP, Human (HEK293, His)** CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P78105

	*Claudin-18/CLDN18.2* Protein-VLP, Human (Biotinylated, HEK293)** CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (Biotinylated, HEK293) is recommended only for SPR analysis. HY-P78368 can be used in animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P700440

	*Claudin-18/CLDN18.2* Protein-VLP, Cynomolgus (HEK293, His)** CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Cynomolgus	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Cynomolgus (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P704504

	*Claudin-18/CLDN18.2* Protein-Nanodisc, Human (sf9, Twin Strep)** CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	sf9 insect cells
	CLDN18-VLPs (Claudin 18 virus-like particles) play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. Claudin-18/CLDN18.2 Protein-Nanodisc, Human (sf9, Twin Strep) is the recombinant human-derived Claudin-18/CLDN18.2 protein, expressed by sf9 insect cells, with C-Twin-Strep and N-His labeled tag.

HY-P705008

	*Claudin-18/CLDN18.2* Protein-Nanodisc, Human (Biotinylated, sf9, Flag, His-Avi)** CLDN18; CLDN18.2; Claudin-18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	sf9 insect cells

HY-P70701

	*Claudin-18/CLDN18.2* Protein, Human (His)** Claudin-18; CLDN18	Human	E. coli
	CLDN18 play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. Claudin-18/CLDN18.2 Protein, Human (His) is the recombinant human-derived Claudin-18/CLDN18.2 protein, expressed by E. coli , with N-8*His labeled tag. The complete sequence length is 172 amino acids. In addition to the target fragment P56856-2 (D28-L76), there are other fusion sequences that play a role in stabilizing the extracellular region.

HY-P700404

	*Claudin-18/CLDN18.2* Protein-VLP, Mouse (HEK293, His)** rHuClaudin-18/CLDN18, His; Claudin-18; CLDN18	Mouse	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Mouse (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

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HY-P81773

	*Claudin 18.2* Antibody** CLDN 18.2,Claudin 18.2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Claudin 18.2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Claudin 18.2.

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