4 Results for "

Calphostin C

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "Calphostin C" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-105416
CAS No.: 121263-19-2
Purity:  99.00%
Synonyms: UCN-1028C
Target:  

Antibiotic PKC Apoptosis

Research Areas:  

Metabolic Disease Cancer

Calphostin C is a highly selective PKC inhibitor (IC50=0.05 μM) and tumor apoptosis inducer. Calphostin C competitively binds to PKC and inhibits PKC-mediated phosphorylation signal transduction. Calphostin C restores Na+/K+ ATPase activity in the sciatic nerve of diabetic mice and improves neuropathy. Calphostin C can be used in the study of anti-tumor and diabetic complications .
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Cat. No.: HY-N19700
CAS No.: 124986-26-1
Target:  

PKC

Calphostin D is a protein kinase C (Protein Kinase, PKC) inhibitor with an IC50 of 6.4 μM. Calphostin D achieves selective inhibition by interacting with the unique C1 regulatory domain of PKC. As a photosensitizer, Calphostin D generates reactive oxygen species upon exposure to light. Calphostin D can be used in cancer-related research .
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Cat. No.: HY-N19701
CAS No.: 124857-59-6
Target:  

PKC

Calphostin I is a selective protein kinase C (PKC) inhibitor with an IC50 of 0.14 μM in rats. Calphostin I interacts with the regulatory domain of PKC, and the aromatic groups at its C-14 and C-17 positions contribute to enhanced potency and selectivity, with no inhibition of cyclic adenosine monophosphate-dependent protein kinase (PKA) at high concentrations. Calphostin I can be used in research related to cervical cancer and breast cancer .
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Cat. No.: HY-N19702
CAS No.: 124824-06-2
Target:  

PKC PKA

Calphostin B is a protein kinase C (PKC) inhibitor with an IC50 of 1.04 μM in rats and an IC50 of 22.9 μM for bovine cyclic adenosine monophosphate-dependent protein kinase (PKA). Calphostin B bears aromatic structures at positions C-14 and C-17, which accounts for its higher selectivity for PKC over PKA. Calphostin B can be used in studies related to human cervical cancer and human breast cancer .
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