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Carbapenem Antibiotic

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13678
    Meropenem
    30+ Cited Publications

    SM 7338

    		 Penicillin-binding protein (PBP) Bacterial Antibiotic Infection Cancer
    Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
    Meropenem
  • HY-B1369A
    Imipenem
    Maximum Cited Publications
    35 Publications Verification

    N-Formimidoyl thienamycin; MK0787

    		 Antibiotic Bacterial Infection
    Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .
    Imipenem
  • HY-B1369
    Imipenem monohydrate
    30+ Cited Publications

    N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate

    		 Antibiotic Bacterial Infection
    Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .
    Imipenem monohydrate
  • HY-13678A
    Meropenem trihydrate
    30+ Cited Publications

    SM 7338 trihydrate

    		 Penicillin-binding protein (PBP) Bacterial Antibiotic Infection Cancer
    Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
    Meropenem trihydrate
  • HY-A0076
    Tebipenem
    5+ Cited Publications

    LJC 11036

    		 Bacterial Antibiotic Infection
    Tebipenem is an orally available carbapenem antibiotic, shows broad-spectrum activity against Gram-positive and -negative bacteria, except for Pseudomonas aeruginosa.
    Tebipenem
  • HY-147429
    Zosurabalpin

    Abx MCP; RG6006

    		 Antibiotic Bacterial Infection
    Zosurabalpin is a polypeptide antibiotic targeting LPS transporter (LptB2FGC complex), which can block the transport of LPS and lead to endotoxin accumulation in cells, and has shown excellent antibacterial activity against Carbapenem-resistant Acinetobacter baumanni (CRAB) .
    Zosurabalpin
  • HY-13678S
    Meropenem-d6

    SM 7338-d6

    		 Bacterial Antibiotic Infection
    Meropenem-d6 is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
    Meropenem-d6
  • HY-111521
    Meropenem-vaborbactam

    Carbavance

    		 Antibiotic Bacterial Beta-lactamase Infection
    Meropenem-vaborbactam (Carbavance) is a Carbapenem Antibiotic and Boronic acid-based beta-lactamase inhibitor, is a fixed-dose combination product with potent in vitro activity against Enterobacteriaceae that are Klebsiella pneumoniae carbapenemase producers. Meropenem-vaborbactam exhibits activity against Pseudomonas aeruginosa isolates , with an MIC50 of 0.5 μg/mL and an MIC90 of 8 μg/mL .
    Meropenem-vaborbactam
  • HY-W008806
    N-(3-Oxohexanoyl)-L-homoserine lactone

    OHHL; N-(3-Oxohexanoyl)homoserine lactone

    		 Bacterial Infection Inflammation/Immunology
    N-(3-Oxohexanoyl)-L-homoserine lactone (OHHL; N-(3-Oxohexanoyl)homoserine lactone) is a specific agonist of LuxR-type transcription factor CarR with a Kd of 1.8 μM. N-(3-Oxohexanoyl)-L-homoserine lactone activates CarR by inducing protein multimerization, promoting its binding to target DNA sequences in the carR-carA intergenic region, thereby upregulating the transcription of carbapenem biosynthesis genes. N-(3-Oxohexanoyl)-L-homoserine lactone acts as a quorum sensing signal molecule, enabling bacteria to coordinate the production of carbapenem antibiotics in a cell density-dependent manner. N-(3-Oxohexanoyl)-L-homoserine lactone is used to study bacterial quorum sensing mechanisms, especially the secondary metabolism and virulence factor regulatory pathways of Erwinia carotovora and Yersinia enterocolitica .
    N-(3-Oxohexanoyl)-L-homoserine lactone
  • HY-W561907
    IMipenem and cilastatin sodium

    		Antibiotic Bacterial Infection
    IMipenem and cilastatin sodium is a broad-spectrum Carbapenem Antibiotic combination. Imipenem (HY-B1369A) is a Carbapenem antibiotic. IMipenem demonstrates excellent activity against gram-positive and gram-negative aerobic and anaerobic organisms. Cilastatin (HY-A0166) is a renal Dehydropeptidase inhibitor that inhibits the metabolism of Imipenem by renal brush-border enzymes, thus increasing imipenem concentrations in urine .
    IMipenem and cilastatin sodium
  • HY-147349
    Pilabactam sodium

    ANT3310 sodium

    		 Beta-lactamase Bacterial Infection
    Pilabactam (ANT3310) sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam sodium can be used in the research of bacterial infection .
    Pilabactam sodium
  • HY-B1369R
    Imipenem monohydrate (Standard)

    N-Formimidoyl thienamycin monohydrate (Standard); MK0787 monohydrate (Standard)

    		 Reference Standards Antibiotic Bacterial Infection
    Imipenem (monohydrate) (Standard) is the analytical standard of Imipenem (monohydrate). This product is intended for research and analytical applications. Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .
    Imipenem monohydrate (Standard)
  • HY-16955A
    Plazomicin sulfate
    1 Publications Verification

    ACHN 490 sulfate

    		 Antibiotic Bacterial Infection
    Plazomicin (ACHN 490) sulfate is a semi-synthetic aminoglycoside Antibiotic. Plazomicin sulfate acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin sulfaten is not modified by various common aminoglycoside-modifying enzymes. Plazomicin sulfate selectively inhibits MATE2-K. Plazomicin sulfate exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales .
    Plazomicin sulfate
  • HY-13678AR
    Meropenem trihydrate (Standard)

    SM 7338 trihydrate (Standard)

    		 Penicillin-binding protein (PBP) Reference Standards Bacterial Antibiotic Infection Cancer
    Meropenem (trihydrate) (Standard) is the analytical standard of Meropenem (trihydrate). This product is intended for research and analytical applications. Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
    Meropenem trihydrate (Standard)
  • HY-B1127
    Betamipron

    N-Benzoyl-β-alanine

    		 Antibiotic Bacterial Infection Endocrinology
    Betamipron (N-benzoyl-β-alanine) is a carbapenem β-lactam antibiotic with antibacterial activity against most Gram-positive and Gram-negative aerobic and anaerobic bacteria. Betamipron can target and inhibit renal organic anion transporters, alleviate renal injury caused by Cisplatin (HY-17394), without interfering with the biological activity of cisplatin. Betamipron is often used in combination with panipenem, which can attenuate the renal effects induced by panipenem and slightly promote the proliferation of Clostridium difficile in the cecum. Betamipron can be used in studies related to renal injury and bacterial infection .
    Betamipron
  • HY-137927
    Benapenem

    		Antibiotic Others
    Benapenem is a carbapenem-type agent that belongs to the broad-spectrum β-lactam antibiotic class.
    Benapenem
  • HY-125416
    Streptothricin F

    		Antibiotic Bacterial Infection
    Streptothricin F is a bactericidal antibiotic. Streptothricin F interacts with the 30S subunit of 70S ribosome. Streptothricin F shows rapid, bactericidal activity against highly drug-resistant, carbapenem-resistant Enterobacterales (CRE) (MIC50 and MIC90: 2 and 4 μM, respectively) and Acinetobacter baumannii .
    Streptothricin F
  • HY-16955
    Plazomicin

    ACHN 490

    		 Antibiotic Bacterial Infection Inflammation/Immunology
    Plazomicin (ACHN 490) is a semi-synthetic aminoglycoside Antibiotic. Plazomicin acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin is not modified by various common aminoglycoside-modifying enzymes. Plazomicin selectively inhibits MATE2-K. Plazomicin exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales .
    Plazomicin
  • HY-147349A
    Pilabactam

    ANT3310

    		 Bacterial Beta-lactamase Infection
    Pilabactam (ANT3310) is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam can be used in the research of bacterial infection .
    Pilabactam
  • HY-A0076R
    Tebipenem (Standard)

    LJC 11036 (Standard)

    		 Reference Standards Bacterial Antibiotic Infection
    Tebipenem (Standard) is the analytical standard of Tebipenem. This product is intended for research and analytical applications. Tebipenem is an orally available carbapenem antibiotic, shows broad-spectrum activity against Gram-positive and -negative bacteria, except for Pseudomonas aeruginosa.
    Tebipenem (Standard)
  • HY-122699
    LN-1-255 sodium

    		Beta-lactamase Bacterial Infection
    LN-1-255 sodium is a β-lactamase inhibitor. LN-1-255 sodium has broad-spectrum inhibitory effect on type D carbapenemases (CHDLs) with an IC50 for OXA-48 of 3 nM, and it also has strong activity against OXA-23, OXA-24/40, etc. LN-1-255 sodium combined with carbapenem antibiotics has a synergistic effect. LN-1-255 sodium can be used to study the bacterial resistance crisis caused by CHDLs .
    LN-1-255 sodium
  • HY-19246
    DZ-2640

    		Antibiotic Bacterial Infection
    DZ-2640 is an orally active Carbapenem antibiotic, a prodrug of DU-6681 (HY-19247). DU-6681 exhibits antibacterial activity against a broad spectrum of gram-positive and -negative bacteria .
    DZ-2640
  • HY-122174
    ME-1036

    CP-5609

    		 Antibiotic Bacterial Infection
    ME-1036 (CP-5609) is a carbapenem antibiotic. ME-1036 against resistant Gram-positive organisms, including Methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococci (VRE), and ESBL-producing E. coli and K. pneumoniae but is not effective against P. aeruginosa .
    ME-1036
  • HY-N14182
    Asparenomycin A

    		Antibiotic Bacterial Infection
    Asparenomycin A is a carbapenem antibiotic with strong β-lactamase inhibition activities .
    Asparenomycin A
  • HY-N14185
    Asparenomycin C

    		Antibiotic Bacterial Infection
    Asparenomycin C is a carbapenem antibiotic with strong β-lactamase inhibition activities .
    Asparenomycin C
  • HY-N14183
    Asparenomycin B

    		Antibiotic Bacterial Infection
    Asparenomycin B is a carbapenem antibiotic with strong β-lactamase inhibition activities .
    Asparenomycin B
  • HY-N14175
    Epithienamycin C

    		Antibiotic Bacterial Infection
    Epithienamycin C is a carbapenem antibiotic. Epithienamycin C has anti-Gram-positive and Gram-negative bacteria activity .
    Epithienamycin C
  • HY-N14174
    Epithienamycin A

    		Antibiotic Bacterial Infection
    Epithienamycin A is a carbapenem antibiotic. Epithienamycin A has anti-Gram-positive bacteria and anti-Gram-negative bacteria activity .
    Epithienamycin A
  • HY-N14461
    Pluracidomycin D

    		Antibiotic Bacterial Infection
    Pluracidomycin D is a carbapenem antibiotic. Pluracidomycin D has anti-Gram-positive bacteria and Gram-negative bacteria activities .
    Pluracidomycin D
  • HY-N14209
    Epithienamycin D

    		Antibiotic Bacterial Infection
    Epithienamycin D is a carbapenem antibiotic. Epithienamycin D has anti-Gram-positive bacteria and anti-Gram-negative bacteria activity .
    Epithienamycin D
  • HY-N14210
    Epithienamycin F

    		Antibiotic Bacterial Infection
    Epithienamycin F is a carbapenem antibiotic. Epithienamycin F has anti-Gram-positive bacteria and anti-Gram-negative bacteria activity .
    Epithienamycin F
  • HY-N14458
    Pluracidomycin A2

    PLM A2

    		 Antibiotic Bacterial Infection
    Pluracidomycin A2 (PLM A2) is a carbapenem antibiotic and has anti-Gram-positive bacteria and Gram-negative bacteria activities .
    Pluracidomycin A2
  • HY-N14459
    Pluracidomycin C2

    		Antibiotic Bacterial Infection
    Pluracidomycin C2 is a carbapenem antibiotic. Pluracidomycin C2 has anti-Gram-positive bacteria and Gram-negative bacteria activities .
    Pluracidomycin C2
  • HY-N14460
    Pluracidomycin C3

    		Antibiotic Bacterial Infection
    Pluracidomycin C3 is a carbapenem antibiotic. Pluracidomycin C3 has anti-Gram-positive bacteria and Gram-negative bacteria activities .
    Pluracidomycin C3
  • HY-170803
    KPC-IN-1

    		Bacterial Infection
    KPC-IN-1 (compound 1e) is an inhibitor of Klebsiella pneumoniae carbapenemase KPC-2 (IC50=8.3 nM). KPC is a β-lactamase expressed in Gram-negative bacteria that hydrolyzes carbapenems. KPC causes significant bacterial resistance to carbapenem antibiotics .
    KPC-IN-1
  • HY-105180
    Lenapenem

    BO-2727 free acid

    		 Bacterial Antibiotic Infection
    Lenapenem (BO-2727 free acid), a carbapenem antibiotic, has potent antibacterial activity against Gram-positive and Gram-negative bacteria including P. aeruginosa .
    Lenapenem
  • HY-N14693
    Pluracidomycin B

    		Antibiotic Bacterial Infection
    Pluracidomycin B is a carbapenem antibiotic. Pluracidomycin B has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .
    Pluracidomycin B
  • HY-N14694
    Pluracidomycin C1

    		Antibiotic Bacterial Infection
    Pluracidomycin C1 is a carbapenem antibiotic. Pluracidomycin C1 has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .
    Pluracidomycin C1
  • HY-N14692
    Pluracidomycin A1

    		Antibiotic Bacterial Infection
    Pluracidomycin A1 is a carbapenem antibiotic . Pluracidomycin A1 has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .
    Pluracidomycin A1
  • HY-120203
    DA 1131

    		Antibiotic Bacterial Infection
    DA 1131 is an anionic Carbapenem antibiotic. DA 1131 has broad spectrum antibacterial activity for both gram-positive and gram-negative organisms. DA 1131 is resistant to degradation by various types of β-lactamases .
    DA 1131
  • HY-W743988
    Cilastatin ammonium salt

    		Antibiotic Bacterial Infection
    Cilastatin ammonium salt is an antibiotic that is relatively effective against Gram-positive cocci with a half-life of 3-4 h .
    Cilastatin ammonium salt
  • HY-120242
    N-(3-Oxobutanoyl)-L-homoserine lactone

    		Bacterial Infection
    N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) is a carbapenem antibiotic biosynthesis autoregulator in Erwinia carotovora ATCC 39048. N-(3-Oxobutanoyl)-L-homoserine lactone induces expression of rhiI in R. leguminosarum .
    N-(3-Oxobutanoyl)-L-homoserine lactone
  • HY-W740053
    Meropenem sodium

    		Penicillin-binding protein (PBP) Bacterial Antibiotic Infection Cancer
    Meropenem sodium is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem sodium has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
    Meropenem sodium
  • HY-173472
    MBL-IN-5

    		Bacterial Beta-lactamase Infection
    MBL-IN-5 is a metallo-β-lactamase (MBL) inhibitor. MBL-IN-5 inhibits three clinically relevant B1 subfamily MBLs (NDM-1, VIM-1, and IMP-1) with IC50s of 0.05  nM, 14  nM and 21 nM respectively. MBL-IN-5 remarkably enhances carbapenems’ effectiveness against MBL-producing clinical strains and significantly reduces the bacterial load in a neutropenic murine thigh infection model combined with the IPM antibiotic .
    MBL-IN-5
  • HY-118013
    NDM-1 inhibitor-2

    		Bacterial Infection
    NDM-1 inhibitor-2 is an inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1) and has the ability to inhibit NDM-1 activity. NDM-1 inhibitor-2 exhibits a good inhibitory effect on drug-resistant bacterial strains that overexpress NDM-1. When NDM-1 inhibitor-2 is used in combination with the carbapenem antibiotic meropenem, a favorable synergistic effect can be produced .
    NDM-1 inhibitor-2
  • HY-B1127R
    Betamipron (Standard)

    N-Benzoyl-β-alanine (Standard)

    		 Reference Standards Bacterial Antibiotic Infection Endocrinology
    Betamipron (Standard) is the analytical standard of Betamipron (HY-B1127). This product is intended for research and analytical applications. Betamipron (N-benzoyl-β-alanine) is a carbapenem β-lactam antibiotic with antibacterial activity against most Gram-positive and Gram-negative aerobic and anaerobic bacteria. Betamipron can target and inhibit renal organic anion transporters, alleviate renal injury caused by Cisplatin (HY-17394), without interfering with the biological activity of cisplatin. Betamipron is often used in combination with panipenem, which can attenuate the renal effects induced by panipenem and slightly promote the proliferation of Clostridium difficile in the cecum. Betamipron can be used in studies related to renal injury and bacterial infection .
    Betamipron (Standard)
  • HY-105180A
    Lenapenem hydrochloride hydrate

    BO-2727 hydrochloride hydrate

    		 Antibiotic Bacterial Infection
    Lenapenem (BO-2727) hydrochloride hydrate, a carbapenem antibiotic, has potent antibacterial activity against Gram-positive and Gram-negative bacteria including P. aeruginosa .
    Lenapenem hydrochloride hydrate
  • HY-E71077
    (5R)-Carbapenem-3-carboxylate synthase

    		Biochemical Assay Reagents Others
    (5R)-Carbapenem-3-carboxylate synthase (EC 1.14.20.3) requires Fe2+. The enzyme is involved in the biosynthesis of the carbapenem β-lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum. (5R)-Carbapenem-3-carboxylate synthase (EC 1.14.20.3) catalyses a stereoinversion at C-5 and introduces a double bond between C-2 and C-3.
    (5R)-Carbapenem-3-carboxylate synthase
  • HY-P11720
    M104 peptide

    		Beta-lactamase Bacterial Infection
    M104 peptide is an OXA-48 carbapenemase inhibitor and antibiotic potentiator. M104 peptide effectively blocks the binding and active site cavity of OXA-48 . M104 peptide restores Meropenem (HY-13678)’s antibacterial activity against OXA-48-producing Klebsiella pneumoniae. M104 peptide can be used for the research of Carbapenem-resistant Klebsiella pneumoniae infection .
    M104 peptide
  • HY-174852
    Antibacterial agent 285

    		Antibiotic Bacterial Infection
    Antibacterial agent 285 (Compound 3) is a cephalosporin antibiotic. Antibacterial agent 285 has significant antibacterial activity against gram-negative bacterium with MICs of 0.125-0.5, 0.125-0.5 and 0.125-2 μg/mL for carbapenem-resistant Acinetobacter baumannii (CRAB), Klebsiella pneumoniae (CRE) and Pseudomonas aeruginosa (CRPA), respectively. Antibacterial agent 285 can be used for bacterial infection research, such as complicated urinary tract infections (cUTI) and kidney infections .
    Antibacterial agent 285

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