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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

Caspase-independent cell death

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Peptides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103661
    BI-6C9
    3 Publications Verification

    		 Mitochondrial Metabolism Apoptosis Neurological Disease
    BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons .
    BI-6C9
  • HY-117200
    Necrostatin-7

    Nec-7

    		 Necroptosis Cancer
    Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase .
    Necrostatin-7
  • HY-112774A
    ICSN3250 hydrochloride

    		mTOR Autophagy Atg8/LC3 p62 Ribosomal S6 Kinase (RSK) Cancer
    ICSN3250 hydrochloride is a halitulin analogue and a mTORC1 inhibitor. ICSN3250 hydrochloride directly binds to mTOR's FRB domain and displaces phosphatidic acid (PA), reversing mTORC1 activation. ICSN3250 hydrochloride shows high cytotoxicity in cancer cells (nanomolar concentration) through a caspase-independent cell death mechanism. ICSN3250 hydrochloride specifically inhibits the mTORC1 pathway, inducing autophagy and G0-G1 cell-cycle arrest in cancer cells. ICSN3250 hydrochloride can be used for the study of cancer .
    ICSN3250 hydrochloride
  • HY-P10371
    PKHB1

    txCD47

    		 Reactive Oxygen Species (ROS) Thrombopoietin Receptor Mitochondrial Metabolism HSP HSV CD47 Infection Inflammation/Immunology Cancer
    PKHB1 (txCD47) is a CD47 agonist and Thrombospondin-1 peptide mimetic. PKHB1 activates CD47 and triggers Caspase-independent, calcium-dependent cell death via mitochondrial alterations, ROS production, endoplasmic reticulum morphological changes, and dissipation of mitochondrial membrane potential. PKHB1 induces the exposure of Calreticulin, HSP70, and HSP90, thereby driving immunogenic cell death. PKHB1 promotes intratumoral CD8 + T cell infiltration and inhibits breast tumorigenesis. PKHB1 reduces HSV-1 levels and alleviates the severity of herpes simplex keratitis. PKHB1 can be used in research related to breast cancer, herpes simplex keratitis, and T-cell acute lymphoblastic leukemia .
    PKHB1
  • HY-161661
    Anticancer agent 223

    		Caspase Cancer
    Anticancer agent 223 (Compound V-d) is an anticancer agent that triggers cell death through caspase-dependent and caspase-independent mechanisms. Anticancer agent 223 inhibits tumor spheroid formation and resensitizes cisplatin (HY-17394)-resistant A2780 cells to cisplatin (HY-17394) treatment .
    Anticancer agent 223
  • HY-129765
    Thiobenzanilide 63T

    		Reactive Oxygen Species (ROS) Cancer
    Thiobenzanilide 63T (63T) is a small molecule that selectively induces cancer cell death in a caspase-independent pathway. Thiobenzanilide 63T induces reactive oxygen species and lipid peroxidation. Thiobenzanilide 63T demonstrates strong cytotoxic activity against a lung-derived cancer cell line. Thiobenzanilide 63T decreases the expression of heme oxygenase (HO-1) in A549 cells .
    Thiobenzanilide 63T
  • HY-179037
    NecroX-2

    		Necroptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism Neurological Disease
    NecroX-2 is a potent inhibitor of caspase-independent necrosis. NecroX-2 exhibits antioxidant activity by scavenging DPPH radicals and peroxynitrite. NecroX-2 inhibits t-BHP-induced mitochondrial ROS/RNS generation, and protects t-BHP and Doxorubicin (HY-15142A)-induced cell death in vitro. NecroX-2 can be used for research on neurological diseases .
    NecroX-2
  • HY-111168
    MLS-2064

    		GSK-3 Cancer
    MLS-2064 is a 3'-substituted 7-haloindirubin with antitumor activity. MLS-2064 induces caspase-independent cell death. MLS-2064 induces dose-dependent cell death in various human cancer cell lines. MLS-2064 shows no significant inhibitory activity against CDK1 and CDK5 kinases, and only weak inhibitory activity against GSK-3 kinase (IC50: 5 μM). MLS-2064 can be used in research related to colon cancer, breast cancer, lung cancer, prostate cancer, liver cancer, and neuroblastoma .
    MLS-2064
  • HY-112774
    ICSN3250

    		mTOR Autophagy Atg8/LC3 p62 Ribosomal S6 Kinase (RSK) Cancer
    ICSN3250 is a halitulin analogue and specific mTORC1 inhibitor. ICSN3250 directly binds to mTOR's FRB domain and displaces phosphatidic acid (PA), reversing mTORC1 activation. ICSN3250 shows high cytotoxicity in cancer cells (nanomolar concentration) through a caspase-independent cell death mechanism. ICSN3250 specifically inhibits the mTORC1 pathway, inducing autophagy and G0-G1 cell-cycle arrest in cancer cells. ICSN3250 can be used for the study of cancer .
    ICSN3250
  • HY-103661R
    BI-6C9 (Standard)

    		Reference Standards Mitochondrial Metabolism Apoptosis Neurological Disease
    BI-6C9 (Standard) is the analytical standard of BI-6C9 (HY-103661). This product is intended for research and analytical applications. BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons .
    BI-6C9 (Standard)

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