Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
Clonidine
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "Clonidine" in MCE Product Catalog:
7
Target:
Research Areas:
Clonidine is an alpha 2-adrenergic agonist .
7
Target:
Research Areas:
Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
Research Areas:
Clonidine (Standard) is the analytical standard of Clonidine. This product is intended for research and analytical applications. Clonidine is an alpha 2-adrenergic agonist .
Cat. No.: HY-B0409S
CAS No.: 62497-68-1
Cat. No.: HY-12721S
CAS No.: 67151-02-4
Cat. No.: HY-155297
CAS No.: 55248-23-2
Synonyms: FLA-136
Target:
Research Areas:
Nebidrazine is a centrally-acting hypotensive agent compared to clonidine, demonstrating weaker cardiovascular effects in rats. It induces dose-dependent hypotension and bradycardia when administered intracerebroventricularly (i.c.v.), with significantly lower sedative potential than clonidine in conscious rats. Yohimbine attenuates the cardiovascular effects of both Nebidrazine and clonidine, suggesting involvement of central alpha-autoreceptors sensitive to yohimbine. Unlike clonidine, Nebidrazine does not affect peripheral alpha-adrenoceptors in pithed rats, indicating a selective central mechanism. Chemical sympathectomy reduces Nebidrazine's cardiovascular effects more than clonidine's, and metiamide diminishes responses to both drugs, implicating central histamine receptors. These findings highlight Nebidrazine's distinct pharmacological profile and potential therapeutic application in managing hypertension through central alpha-autoreceptor stimulation .
Cat. No.: HY-B0409AR
CAS No.: 4205-91-8
Research Areas:
Clonidine (hydrochloride) (Standard) is the analytical standard of Clonidine (hydrochloride). This product is intended for research and analytical applications. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
Cat. No.: HY-172026
CAS No.: 148950-49-6
Target:
Research Areas:
N-Nitroso clonidine, a nitrosamine, is a metabolite of Clonidine (HY-12721). Clonidine is an alpha 2-adrenergic agonist .
Cat. No.: HY-132423S
CAS No.: 1189988-05-3
Target:
Research Areas:
Aidioxa has the ability to improve delayed gastric emptying in rats. It can partially improve delayed gastric emptying caused by clonidine or restraint stress. The allyltoin part of Aidioxa restores gastric emptying activity by antagonizing α-2 adrenergic receptors. Its aluminum hydroxide part is involved in restoring gastric compliance. Aidioxa can improve both delayed gastric emptying and impaired gastric compliance, both of which play an important role in functional dyspepsia (FD). Aidioxa is a candidate agent for inhibiting FD.
Cat. No.: HY-N8671R
CAS No.: 256520-90-8
Category:
Target:
Cat. No.: HY-121312
CAS No.: 28125-87-3
Synonyms: ST-600
Target:
Research Areas:
Flutonidine (ST-600) is a Clonidine (HY-12721) analogue that shows antihypertensive and sympatholytic effects. The initial hypertension produced by Flutonidine is due to stimulation of the peripheral α1, α2 adrenoceptors and the subsequent fall in blood pressure is due to the stimulation of central α2 adrenoceptors. Flutonidine reduces the arrhythmogenic and lethal effects of ouabain. Flutonidine is promising for research of ventricular arrhythmias caused by cardiac glycosides .
Cat. No.: HY-167637
CAS No.: 57101-48-1
Target:
Research Areas:
4-Hydroxyclonidine is a Clonidine (HY-12721) metabolite. 4-Hydroxyclonidine is as potent as Clonidine in displacing labeled Clonidine from the antibody .
Cat. No.: HY-136693
CAS No.: 98719-20-1
Target:
Research Areas:
L-654284 is an α2-adrenergic receptor antagonist with significant selectivity. L-654284 competes with the binding of 3H-clonidine and 3H-rauwolscine in vitro and shows Ki values of 0.8 nM and 1.1 nM, respectively. L-654284 can block the protrusion effect of clonidine in isolated vas deferens in rats, with a pA2 value of 9.1. L-654284 exhibits remarkable selectivity for α2 and α1 adrenergic receptors, and exhibits a Ki of 110 nM in inhibiting 3H-prazosin binding. L-654284 can significantly increase the turnover rate of norepinephrine in rat cerebral cortex in vivo, showing α2-adrenergic receptor blocking activity in the central nervous system .
Cat. No.: HY-W744000
CAS No.: 2519452-56-1
Target:
Research Areas:
Clonidine impurity 1 is an impurity of Clonidine.
Cat. No.: HY-W012753
CAS No.: 5391-39-9
Synonyms: Clonidine impurity 2
Target:
Research Areas:
1-Acetyl-2-imidazolidinone (Clonidine impurity 2) is a drug impurity.
Cat. No.: HY-136492
CAS No.: 54707-71-0
Target:
Research Areas:
Acetylclonidine is a derivative of Clonidine (HY-12721). Acetylclonidine is promising for research of ocular antihypertensive agents for glaucoma .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
