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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
DNA gyrase subunit A
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "DNA gyrase subunit A" in MCE Product Catalog:
12
12 Publications Verification
Cat. No.: HY-16742B
CAS No.: 1624306-20-2
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Gepotidacin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. Gepotidacin mesylate hydrate inhibits bacterial DNA replication by blocking topoisomerase enzymes. Gepotidacin mesylate hydrate selectively inhibits topoisomerase IV and the B subunit of DNA gyrase .
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Infection Microorganisms Antibiotics Resistance Selection Disease Research Antibacterial Disease Research Fields Other Antibiotics
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Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .
Cat. No.: HY-123515
CAS No.: 39868-96-7
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Clorobiocin is an antibacterial agent with an IC50 of 0.21 μM against the B subunit of E. coli DNA gyrase. Clorobiocin targets the mLaC protein of Gram-negative bacteria. Clorobiocin potently inhibits bacterial DNA replication. Clorobiocin can be used in studies on Gram-negative bacterial infections, such as Acinetobacter baumannii and E. coli infections .
Cat. No.: HY-B0398S
CAS No.: 1189467-36-4
Cat. No.: HY-N21897
CAS No.: 744218-20-0
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Cat. No.: HY-189125
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Anticancer agent 360 is a broad-spectrum antibacterial agent. Anticancer agent 360 binds to the ATP pocket of the GyrB subunit of DNA gyrase via an Arg84 salt bridge, interfering with gyrase-dependent DNA supercoiling. Anticancer agent 360 disrupts bacterial biofilms and inhibits the metabolic activity of respiratory chain dehydrogenases. Anticancer agent 360 exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and fungal strains. Anticancer agent 360 exerts selective cytotoxicity against liver cancer cells. Anticancer agent 360 can be used in studies related to bacterial infections and liver cancer .
Cat. No.: HY-189124
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Antibacterial agent 372 is a potent antibacterial agent. Antibacterial agent 372 is a DNA gyrase inhibitor that binds to the ATP-binding pocket of the GyrB subunit, downregulates gyrB gene expression, and impedes DNA replication and supercoiling. Antibacterial agent 372 exhibits broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Antibacterial agent 372 can be used for research on microbial infections .
Cat. No.: HY-107044
CAS No.: 364069-14-7
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DK 507k is an orally active 8-methoxyquinolone Antibacterial agent. DK 507k targets DNA gyrase subunit A (GyrA) and modulates the function of GyrA. DK 507k inhibits the growth of various Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa and Methicillin (HY-121544)-resistant Staphylococcus aureus. DK 507k eliminates Penicillin-tolerant Streptococcus pneumoniae from the lungs of mice. DK 507k can be used in research related to sepsis and *Streptococcus pneumoniae* pneumonia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
