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DOTA derivative

" in MedChemExpress (MCE) Product Catalog:

35

Inhibitors & Agonists

22

Biochemical Assay Reagents

4

Peptides

4

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Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-131326
    DOTA-tris(tBu)ester NHS ester

    		Biochemical Assay Reagents Cancer
    DOTA-tris(tBu)ester NHS ester is a bifunctional precursor to a DOTA-based chelating agent. DOTA-tris(tBu)ester NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules, and upon deprotection forms stable complexes with metal ions for applications in molecular imaging .
    DOTA-tris(tBu)ester NHS ester
  • HY-156038
    (S)-p-SCN-Bn-DOTA

    		Biochemical Assay Reagents Others
    (S)-p-SCN-Bn-DOTA is a bifunctional chelator (BFC), a macrocyclic DOTA derivative for tumor pretargeting. (S)-p-SCN-Bn-DOTA can be used for the conjugation of peptides and radionuclides, such as as a linker for In-111 labeled radioimmunoconjugates (RICs) for single photon emission tomography (SPECT) and in vitro biodistribution studies .
    (S)-p-SCN-Bn-DOTA
  • HY-153552A
    NH2-UAMC1110 TFA

    		FAP Cancer
    NH2-UAMC1110 TFA is an aminobutoxy derivative of the fibroblast activation protein (FAP) inhibitor UAMC1110 (HY-100684), and is a precursor compound for the synthesis of FAP inhibitor probes, not directly used in bioactivity experiments. For example, NH2-UAMC1110 TFA is involved in the synthesis of the radiotracer FAPI-QS, which exhibits high tumor selectivity and high dose effect, and has been used in tumor diagnosis. NH2-UAMC1110 TFA structurally incorporates an active amino group, allowing it to form covalent bonds with various molecules (such as DOTA, DATA5m, radionuclide chelators, etc.) to synthesize molecular imaging probes or targeted compounds with the ability to target FAP. NH2-UAMC1110 TFA specifically binds to the FAP active site, inhibiting its proline-selective serine protease activity (including dipeptidyl peptidase and endopeptidase activity), blocking FAP-mediated tissue remodeling-related processes. Its key activity is high targeting and high affinity, and its core function is to act as a targeting module coupled with bifunctional chelators (such as DOTA, DATA5m). NH2-UAMC1110 TFA can be applied to diagnostic imaging studies of tumors expressing FAP (such as colorectal cancer, pancreatic cancer, etc.), and also provides molecular tools for targeted research of FAP-related diseases with high FAP expression, such as fibrosis and arthritis .
    NH2-UAMC1110 TFA
  • HY-12692
    DO3A tert-Butyl ester

    DO3A tert-butyl; DO3A-t-Bu-ester

    		 Drug Derivative Cancer
    DOTA tert-Butyl ester is a cyclic tosamide benzyl derivative.
    DO3A tert-Butyl ester
  • HY-W539916
    Azido-mono-amide-DOTA

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Others
    Azido-mono-amide-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Azido-mono-amide-DOTA can be used for conjugation of peptides and radionuclides.
    Azido-mono-amide-DOTA
  • HY-153552
    NH2-UAMC1110

    		FAP Cancer
    NH2-UAMC1110 is an aminobutoxy derivative of the fibroblast activation protein (FAP) inhibitor UAMC1110 (HY-100684), and is a precursor compound for the synthesis of FAP inhibitor probes, not directly used in bioactivity experiments. For example, NH2-UAMC1110 is involved in the synthesis of the radiotracer FAPI-QS, which exhibits high tumor selectivity and high dose-response, and has been used for tumor diagnosis. NH2-UAMC1110 introduces an active amino group into its structure, enabling it to form covalent bonds with various molecules (such as DOTA, DATA5m, radionuclide chelators, etc.), thereby synthesizing molecular imaging probes or targeted compounds with the ability to target FAP. NH2-UAMC1110 specifically binds to the FAP active site, inhibiting its proline-selective serine protease activity (including dipeptidyl peptidase and endopeptidase activity), blocking FAP-mediated tissue remodeling processes. Its key activity is high targeting and high affinity, and its core function is to be coupled with bifunctional chelators (such as DOTA, DATA5m) as a targeting module. NH2-UAMC1110 can be applied to diagnostic imaging studies of tumors expressing FAP (such as colorectal cancer, pancreatic cancer, etc.), and also provides molecular tools for targeted research of FAP-related diseases with high FAP expression, such as fibrosis and arthritis .
    NH2-UAMC1110
  • HY-W749603
    Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Cancer
    Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.
    Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)
  • HY-W678394
    DOTA-Thiol

    		Biochemical Assay Reagents Others
    DOTA-Thiolis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-Thiol can be used for conjugation of peptides and radionuclides.
    DOTA-Thiol
  • HY-48876
    p-NH2-Bn-DOTA

    		Biochemical Assay Reagents Others
    p-NH2-Bn-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NH2-Bn-DOTA can be used for conjugation of peptides and radionuclides.
    p-NH2-Bn-DOTA
  • HY-W782078
    Butyne-DOTA

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Others
    Butyne-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Butyne-DOTA can be used for conjugation of peptides and radionuclides.
    Butyne-DOTA
  • HY-P10741
    DOTA-EB-TATE

    		Radionuclide-Drug Conjugates (RDCs) Peptide-Drug Conjugates (PDCs) Somatostatin Receptor Cancer
    DOTA-EB-TATE is composed of SST peptide derivative, DOTA-octreotate conjugated a common to an Evans blue analog (EB). DOTA-EB-TATE is a peptide drug conjugate (PDC) improves the pharmacokinetics of SSTR2 analogs and reduces PRRT toxicity. DOTA-EB-TATE can also be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .
    DOTA-EB-TATE
  • HY-W717779
    4-Aminobutyl-DOTA

    		Biochemical Assay Reagents Others
    4-Aminobutyl-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. 4-Aminobutyl-DOTA can be used for conjugation of peptides and radionuclides.
    4-Aminobutyl-DOTA
  • HY-158072
    DOTAM-NHS-ester

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Cancer
    DOTAM-NHS-ester is a bifunctional chelator and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTAM-NHS-ester combines the efficient metal chelating ability of DOTAM macrocyclic ligands with the bioconjugation function of NHS ester active groups, and can be widely used in the biomedical field for metal labeling, molecular imaging and drug delivery development .
    DOTAM-NHS-ester
  • HY-P10444
    DOTA Conjugated JM#21 derivative 7

    		Radionuclide-Drug Conjugates (RDCs) CXCR Cancer
    DOTA Conjugated JM#21 derivative 7 (compound Ligand-7) is a derivative of CXCR4 targeting peptide conjugated with DOTA and can be used to produce radioligands. Radiolabeled DOTA Conjugated JM#21 derivative 7, i.e., 177Lu-DOTA, has excellent CXCR4 tumor targeting. In vitro biodistribution results of 177Lu-DOTA showed very low uptake in all non-targeted organs except kidney . DOTA Conjugated JM#21 derivative 7 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    DOTA Conjugated JM#21 derivative 7
  • HY-164732
    Fmoc-Lys(DOTA)-OH

    		Amino Acid Derivatives Biochemical Assay Reagents Others
    Fmoc-Lys (DOTA)-OH is an Fmoc-protected Lysine derivative with metal-chelating properties, containing the macrocyclic chelator DOTA. Fmoc-Lys (DOTA)-OH undergoes metallation with Tb or Lu. Fmoc-Lys (DOTA)-OH utilizes metal coordination to protect the carboxyl groups of DOTA. Fmoc-Lys (DOTA)-OH can be used in solid-phase peptide synthesis research .
    Fmoc-Lys(DOTA)-OH
  • HY-W451440
    Butyne-DOTA-tris(t-butyl ester)

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Others
    Butyne-DOTA-tris(t-butyl ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Butyne-DOTA-tris(t-butyl ester) can be used for conjugation of peptides and radionuclides.
    Butyne-DOTA-tris(t-butyl ester)
  • HY-W046355
    Fmoc-D-Dap(Boc)-OH

    		Radionuclide-Drug Conjugates (RDCs) Amino Acid Derivatives Others
    Fmoc-D-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as DOTA-modified peptides and their metal chelates with cancer diagnostic effects .
    Fmoc-D-Dap(Boc)-OH
  • HY-131673A
    (S)-p-SCN-Bn-TCMC hydrochloride

    		Biochemical Assay Reagents Others
    (S)-p-SCN-Bn-TCMC (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. (S)-p-SCN-Bn-TCMC (hydrochloride) can be used for conjugation of peptides and radionuclides.
    (S)-p-SCN-Bn-TCMC hydrochloride
  • HY-12690
    DOTA derivative

    		Drug Derivative Cancer
    DOTA derivative is a cyclic tosamide benzylic derivative.
    DOTA derivative
  • HY-W088413
    DOTA-amide

    		Biochemical Assay Reagents Others
    DOTA-amideis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-amide can be used for conjugation of peptides and radionuclides.
    DOTA-amide
  • HY-128890A
    DOTA-NHS-ester hexafluorophosphate TFA

    		Biochemical Assay Reagents Others
    DOTA-NHS-ester (hexafluorophosphate TFA)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-NHS-ester (hexafluorophosphate TFA) can be used for conjugation of peptides and radionuclides.
    DOTA-NHS-ester hexafluorophosphate TFA
  • HY-P10307
    DOTA-ubiquicidin (29–41)

    		Radionuclide-Drug Conjugates (RDCs) Bacterial Infection
    DOTA-ubiquicidin (29-41), an antimicrobial peptide fragment derivative, can be used for synthesis of [ 68Ga]Ga-DOTA-Ubiquicidin29-41 and then used for imaging of infectious processes using PET/CT . DOTA-ubiquicidin (29–41) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    DOTA-ubiquicidin (29–41)
  • HY-180447
    Tz-Ph-PEG4-NH-DOTA

    		Radionuclide-Drug Conjugates (RDCs) Cancer
    Tz-Ph-PEG4-NH-DOTA (Compound 10) is a 1,2,4,5-tetrazine (Tz) derivative. Tz-Ph-PEG4-NH-DOTA can be used in PET imaging and tumor research .
    Tz-Ph-PEG4-NH-DOTA
  • HY-W250844A
    DO3A trisodium

    		Biochemical Assay Reagents Others
    DO3A (trisodium)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DO3A (trisodium) can be used for conjugation of peptides and radionuclides.
    DO3A trisodium
  • HY-W802013
    DOTA-4AMP

    		Biochemical Assay Reagents Others
    DOTA-4AMPis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-4AMP can be used for conjugation of peptides and radionuclides.
    DOTA-4AMP
  • HY-164981
    p-SCN-Bn-DOTA(tBu)4

    		Drug Intermediate Cancer
    p-SCN-Bn-DOTA(tBu)4 is the derivative of DOTA (HY-W053583). p-SCN-Bn-DOTA(tBu)4 is the component of the Gd(III)-DOTA-IAC, which is a targeted magnetic resonance imaging (MRI) contrast agent for αvβ3 integrin receptor .
    p-SCN-Bn-DOTA(tBu)4
  • HY-W460274
    4-Aminobutyl-DOTA-tris(t-butyl ester)

    		Biochemical Assay Reagents Others
    4-Aminobutyl-DOTA-tris(t-butyl ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. 4-Aminobutyl-DOTA-tris(t-butyl ester) can be used for conjugation of peptides and radionuclides.
    4-Aminobutyl-DOTA-tris(t-butyl ester)
  • HY-W250929
    Maleimido-mono-amide-DOTA-tris(t-Bu ester)

    		Biochemical Assay Reagents Others
    Maleimido-mono-amide-DOTA-tris(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Maleimido-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.
    Maleimido-mono-amide-DOTA-tris(t-Bu ester)
  • HY-W717760
    p-NH2-Bn-DOTA-tetra(t-Bu ester)

    		Biochemical Assay Reagents Others
    p-NH2-Bn-DOTA-tetra(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NH2-Bn-DOTA-tetra(t-Bu ester) can be used for conjugation of peptides and radionuclides.
    p-NH2-Bn-DOTA-tetra(t-Bu ester)
  • HY-W782075
    p-NO2-Bn-DOTA

    		Biochemical Assay Reagents Others
    p-NO2-Bn-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NO2-Bn-DOTA can be used for conjugation of peptides and radionuclides.
    p-NO2-Bn-DOTA
  • HY-W726767
    DO2A

    		Biochemical Assay Reagents Others
    DO2Ais a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DO2A can be used for conjugation of peptides and radionuclides.
    DO2A
  • HY-158077
    (R)-tetraMe-Tetraxetan

    (R)-tetraMe-DOTA

    		 Biochemical Assay Reagents Others
    (R)-tetraMe-Tetraxetanis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. (R)-tetraMe-Tetraxetan can be used for conjugation of peptides and radionuclides.
    (R)-tetraMe-Tetraxetan
  • HY-W782081
    p-SCN-Bn-oxo-DO3A

    		Biochemical Assay Reagents Others
    p-SCN-Bn-oxo-DO3Ais a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-SCN-Bn-oxo-DO3A can be used for conjugation of peptides and radionuclides.
    p-SCN-Bn-oxo-DO3A
  • HY-W782080
    p-NH2-Bn-oxo-DO3A

    		Biochemical Assay Reagents Others
    p-NH2-Bn-oxo-DO3Ais a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NH2-Bn-oxo-DO3A can be used for conjugation of peptides and radionuclides.
    p-NH2-Bn-oxo-DO3A
  • HY-180447A
    Tz-Ph-PEG4-NH-DOTA tetraTFA

    		Radionuclide-Drug Conjugates (RDCs) Cancer
    Tz-Ph-PEG4-NH-DOTA (Compound 10) tetraTFA is a 1,2,4,5-tetrazine (Tz) derivative. Tz-Ph-PEG4-NH-DOTA tetraTFA can be used in PET imaging and tumor research .
    Tz-Ph-PEG4-NH-DOTA tetraTFA

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