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Results for "

EPR

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Peptides

6

Recombinant Proteins

4

Antibodies

6

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136265
    BC-LI-0186
    1 Publications Verification

    		 Aminoacyl-tRNA Synthetase Cancer
    BC-LI-0186 is a potent and selective inhibitor of Leucyl-tRNA synthetase (LRS; LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (IC50=46.11 nM). BC-LI-0186 competitively binds to the RagD interacting site of LRS (Kd=42.1 nM) and has on effects on LRS-Vps34, LRS-EPRS, RagB-RagD association, mTORC1 complex formation or the activities of 12 kinases. BC-LI-0186 can effectively suppress the activity of cancer-associated?MTOR?mutants and the growth of rapamycin-resistant cancer cells.?BC-LI-0186 is a promising agent for lung cancer research .
    BC-LI-0186
  • HY-172279A
    DSPE-PEG2000-TAT

    		Liposome Cancer
    DSPE-PEG2000-TAT is a cell-penetrating peptide-modified PEGylated phospholipid conjugate and cellular uptake enhancer. DSPE-PEG2000-TAT forms via conjugation of Cys-TAT to DSPE-PEG2000-Mal. DSPE-PEG2000-TAT enhances liposomal cellular uptake and siRNA transfection efficiency in glomerular mesangial and macrophage cells. DSPE-PEG2000-TAT can be used for drug delivery .
    DSPE-PEG2000-TAT
  • HY-RS16966
    Ereg Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ereg Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ereg gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ereg Mouse Pre-designed siRNA Set A
    Ereg Mouse Pre-designed siRNA Set A
  • HY-W131302
    Ethylenediaminediacetic acid

    N,N-Ethylenediglycine

    		 Endogenous Metabolite Cancer
    Ethylenediaminediacetic acid (N,N-Ethylenediglycine) is an important ligand that enhances the antiproliferative activity of metal complexes. The complexes formed by ethylenediacetic acid and metal ions exhibited significant antiproliferative properties in MCF-7 cancer cell line. The metal complexes of ethylenediacetic acid were able to interact with DNA and were studied by CD and EPR spectroscopy techniques. Ethylenediaminediacetic acid and its metal complexes were able to induce cell cycle arrest at the G(0)/G(1) phase. The crystal structure analysis of ethylenediacetic acid provided important structural information for understanding its biological activity .
    Ethylenediaminediacetic acid
  • HY-147151
    AMCPy

    		Biochemical Assay Reagents Others
    AMCPy is a potent electron paramagnetic resonance (EPR) brain imaging agent, possessing excellent lipophilicity for blood brain barrier (BBB) penetration .
    AMCPy
  • HY-RS04451
    EPRS1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    EPRS1 Human Pre-designed siRNA Set A contains three designed siRNAs for EPRS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    EPRS1 Human Pre-designed siRNA Set A
    EPRS1 Human Pre-designed siRNA Set A
  • HY-RS04487
    EREG Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    EREG Human Pre-designed siRNA Set A contains three designed siRNAs for EREG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    EREG Human Pre-designed siRNA Set A
    EREG Human Pre-designed siRNA Set A
  • HY-174692
    Human FGF8 mRNA

    		mRNA Cancer
    Human FGF8 mRNA encodes the human fibroblast growth factor 8 (FGF8) protein, a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.
    Human FGF8 mRNA
  • HY-174547
    Human PDX1 mRNA

    		mRNA Metabolic Disease
    Human PDX1 mRNA encodes the human pancreatic and duodenal homeobox 1 (PDX1) protein, a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. PDX1 may be involved in the early development of the pancreas. It also plays a major role in glucose-dependent regulation of insulin gene expression.
    Human PDX1 mRNA
  • HY-W777072
    4-Isocyanato-TEMPO,Technical grade

    		HIV Others
    4-isocyanato TEMPO is a spin labeling reagent used to label the 2’-position in RNA. It has been used to study HIV-1 transactivation response RNA and hammerhead ribosome dynamics by electron paramagnetic resonance (EPR) spectroscopy.
    4-Isocyanato-TEMPO,Technical grade
  • HY-P11145
    Influenza HA (529-537)

    		Influenza Virus Infection Inflammation/Immunology
    Influenza HA (529-537) is the amino acid sequence (IYATVAGSL) at positions 529-537 of the hemagglutinin (HA) of the influenza A virus. Influenza HA (529-537) can be recognized by three different specificities (H1-specific, H2-specific, H1/H2 cross-reactive) of CD8 + cytotoxic T-lymphocyte (CTL) clones. Influenza HA (529-537) can be used to understand T-cell immune specificity and to design new vaccines .
    Influenza HA (529-537)
  • HY-117925
    Personalised postprandial-targeting

    		HBV Others
    Personalised postprandial-targeting is a way to modulate water-heme interactions with activity against low-spin P450 complexes. Personalised postprandial-targeting is able to maintain the axial water ligands of CYP2C9 even in the presence of inhibitors. Personalised postprandial-targeting also allows the hydrogen atoms of the axial water ligands to be observed by EPR spectroscopy, providing insights into the enzyme active site .
    Personalised postprandial-targeting
  • HY-183004
    NCP26

    		Aminoacyl-tRNA Synthetase Apoptosis Caspase PARP c-Myc Cancer
    NCP26 is an ATP-competitive ProRS inhibitor (with a KD of 271 nM in the absence of proline, and a KD of 0.35 nM in the presence of 100 μM proline). NCP26 activates AAR, induces G0/G1 phase arrest, Apoptosis, Caspase cleavage, and PARP cleavage. NCP26 downregulates MYC, TCF3, and CCND1. NCP26 inhibits the growth of multiple myeloma cells. NCP26 can be used for the research of multiple myeloma .
    NCP26
  • HY-180557
    4A-BFA-11

    		Folate Receptor (FR) Cancer
    4A-BFA-11 is a folate-targeted PEG-MMAE conjugate that exhibits specific binding affinity for the folate receptor α (FR-α) (KD = 106.7 nM). 4A-BFA-11 achieves tumor enrichment by combining PEG-mediated long circulation (EPR effect) and folate receptor targeting. 4A-BFA-11 undergoes enzymatic cleavage at the tumor site to release the active payload, enabling precise action. 4A-BFA-11 sefficiently carries, targets, and controls the release of MMAE in tumor tissues in a HeLa mouse model. 4A-BFA-11 can be used for cervical cancer, ovarian cancer, and lung cancer research .
    4A-BFA-11
  • HY-181464
    CAY10565

    		NO Synthase Cardiovascular Disease
    CAY10565 (Compound 3d) is a nitric oxide (NO) donor. CAY10565 releases nitric acid via an acid-catalyzed ring-opening mechanism under acidic conditions. CAY10565 induces vasodilation .
    CAY10565
  • HY-181741
    PI3K-001

    		Cathepsin Inflammation/Immunology
    PI3K-001 is a cathepsin B-responsive prodrug and antifibrotic agent. PI3K-001 undergoes cathepsin B-mediated cleavage of the Val-Ala linker in fibrotic lung lesions to release an active PI3K inhibitor payload, while it remains stable in healthy tissues. PI3K-001 improves collagen deposition, tissue collapse and alveolar injury in fibrotic lung tissues. PI3K-001 is applicable for the research of pulmonary fibrosis .
    PI3K-001

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