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Results for "

FADD

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

2

Recombinant Proteins

8

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-109582
    ADT-OH
    4 Publications Verification

    5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione; ACS 1

    		 Apoptosis FAK Cancer
    ADT-OH is a hydrogen sulfide-releasing donor. ADT-OH induces apoptosis and upregulates FADD. ADT-OH inhibits FAK/Paxillin. ADT-OH has the potential for the research of cancer diseases .
    ADT-OH
  • HY-14622
    Necrostatin 2
    10+ Cited Publications

    		 RIP kinase Cancer
    Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor.
    Necrostatin 2
  • HY-132203
    Necrostatin-34

    		RIP kinase Inflammation/Immunology Cancer
    Necrostatin-34 (Nec-34), a RIPK1 kinase inhibitor, stabilizes RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain .
    Necrostatin-34
  • HY-148454
    Necroptosis-IN-3

    		Necroptosis 11β-HSD Inflammation/Immunology Cancer
    Necroptosis-IN-3 (Compound 69) is a necroptosis inhibitor that inhibits TNF-α induced necroptosis . Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1 .
    Necroptosis-IN-3
  • HY-119369
    FadD32 Inhibitor-1

    		Bacterial Infection
    FadD32 Inhibitor-1 is a potent FadD32 inhibitor with anti-tubercular activity .
    FadD32 Inhibitor-1
  • HY-RS04665
    FADD Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FADD Human Pre-designed siRNA Set A contains three designed siRNAs for FADD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FADD Human Pre-designed siRNA Set A
    FADD Human Pre-designed siRNA Set A
  • HY-RS17138
    Fadd Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fadd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fadd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fadd Mouse Pre-designed siRNA Set A
    Fadd Mouse Pre-designed siRNA Set A
  • HY-RS23584
    Fadd Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fadd Rat Pre-designed siRNA Set A contains three designed siRNAs for Fadd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fadd Rat Pre-designed siRNA Set A
    Fadd Rat Pre-designed siRNA Set A
  • HY-109582R
    ADT-OH (Standard)

    5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione (Standard); ACS 1 (Standard)

    		 Apoptosis FAK Reference Standards Cancer
    ADT-OH (Standard) is the analytical standard of ADT-OH. This product is intended for research and analytical applications. ADT-OH is a hydrogen sulfide-releasing donor. ADT-OH induces apoptosis and upregulates FADD. ADT-OH inhibits FAK/Paxillin. ADT-OH has the potential for the research of cancer diseases .
    ADT-OH (Standard)
  • HY-168770
    Cl-Necrostatin-1

    		RIP kinase TNF Receptor Apoptosis Cardiovascular Disease
    Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion (MCAO). Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases .
    Cl-Necrostatin-1
  • HY-182597
    Tracizoline

    		Imidazoline Receptor 5-HT Receptor Adrenergic Receptor Neurological Disease
    Tracizoline is an orally active I2-imidazoline receptor agonist. Tracizoline functionally modulates I2-imidazoline receptors, regulates hippocampal FADD cell fate adaptor, attenuates mechanical and thermal hyperalgesia, activates α2A-adrenergic receptors with very weak partial agonism, and induces antidepressant-like activity via 5-HT1A receptor activation. Tracizoline can be used for the research of inflammatory pain, neuropathic pain, and depression .
    Tracizoline
  • HY-182307
    OH14

    		Apoptosis Caspase TNF Receptor Cancer
    OH14 is a cellular FLICE-like inhibitory protein (cFLIP) inhibitor and TNF-related apoptosis-inducing ligand (TRAIL) sensitizer. OH14 selectively binds to the DED1 pocket of cFLIP, disrupting its recruitment to the TRAIL-death inducing signalling complex without affecting procaspase-8 recruitment to FADD, allowing procaspase-8 activation. OH14 promotes TRAIL-mediated apoptosis and impairs cell viability in breast cancer systems when combined with TRAIL. OH14 can be used for the research of breast cancer .
    OH14
  • HY-W182790
    Garsevil

    LSL 60101
    Garsevil (LSL 60101) is a biphasic, selective imidazoline I2 receptor (I2-IR) ligand, with a pKi of 9.03 and a Ki of 0.9 nM at the high-affinity site, and a pKi of 5.25 and a Ki of 5.6 nM at the low-affinity site. Garsevil is applicable to research related to Alzheimer's disease .
    Garsevil

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