852391-19-6
852391-19-6
Chemical Structure
Necrostatin 2
- CAS No.: 852391-19-6
- Formula:C13H12ClN3O2
- Molecular Weight:277.71
IUPAC Name: (R)-5-((7-chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione
InChIKey: WIKGAEMMNQTUGL-SNVBAGLBSA-N
SMILES: ClC1=C2C(C(C[C@@H]3C(N(C)C(N3)=O)=O)=CN2)=CC=C1
Biological Activity: Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Necrostatin 2 | 99.78% | Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-14622ARNecrostatin 2 racemate (Standard) -
Similarity Score 1.00
HY-14622BNecrostatin 2 (S enantiomer) -
Similarity Score 0.86
HY-168770Cl-Necrostatin-1 -
Similarity Score 0.83
HY-135826Necroptosis-IN-1 -
Similarity Score 0.72
HY-15760Necrostatin-1 -
Similarity Score 0.70
HY-W782635DL-5-Indolylmethylhydantoin -
Similarity Score 0.65
HY-121954Necrostatin-1 (inactive control) -
Similarity Score 0.62
HY-P2092Cyclo(L-leucyl-L-tryptophyl) -
Similarity Score 0.62
HY-N12900TDD -
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