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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
G protein-coupled Bile Acid Receptor 1
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "G protein-coupled Bile Acid Receptor 1" in MCE Product Catalog:
Cat. No.: HY-146453
CAS No.: 2643391-08-4
Research Areas:
TGR5 Receptor Agonist 3 (Compound 19) is a soft-agent G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) agonist with reduced gallbladder-filling effects (favorable gallbladder safety), with EC50s of 16.4 and 209 nM for hTGR5 and mTGR5, respectively.
Cat. No.: HY-165155
CAS No.: 119515-00-3
Target:
Research Areas:
CysLT1 receptor antagonist-1 (Compound 4) is an antagonist for cysteinyl leukotriene receptor 1 (CysLT1R) with an IC50 of 3.9 μM. CysLT1 receptor antagonist-1 exhibits weak agonist activity against G-protein-coupled bile acid receptor 1 (GPBAR1) with an efficact of 23% at 10 μM. CysLT1 receptor antagonist-1 can be used for asthma and allergic diseases researchs .
Research Areas:
CAY10789 is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases .
Cat. No.: HY-P704194
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: GPBAR1; Membrane-Type Receptor For Bile Acids; G protein-coupled Bile Acid Receptor 1; G-protein coupled Receptor GPCR19; M-BAR; MGC40597; BG37; GPCR; TGR5; G-protein coupled Bile Acid Receptor BG37; GPCR19; Membrane Bile Acid Receptor; GPR131; HGPCR19; G
Species:
Human
Source:
E. coli Cell-free
Cat. No.: HY-168784
CAS No.: 107813-86-5
Target:
Research Areas:
LTD4 antagonist 2 (compound 6) is a leukotriene D4 (LTD4) antagonist with an IC50 of 2.8 μM against cysteinyl leukotriene 1 receptor (CysLT1R). LTD4 antagonist 2 is also a G protein-coupled bile acid receptor 1 (GPBAR1) agonist and can be utilized in research related to colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
