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H292

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By Targets:	Anaplastic lymphoma kinase (ALK) (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (5) Bcr-Abl (2) c-Myc (1) CCR (2) COX (2) Drug Metabolite (3) EGFR (1) Endogenous Metabolite (2) Fat Mass and Obesity-associated Protein (FTO) (2) Ferroptosis (1) Gap Junction Protein (2) Glutathione Peroxidase (1) GSK-3 (1) Integrin (1) Isotope-Labeled Compounds (1) JNK (1) Ligands for Target Protein for PROTAC (1) mTOR (1) NF-κB (2) PARP (1) Reactive Oxygen Species (ROS) (1) Reference Standards (4) Src (2) TNK1 (1)
By Research Areas:	Cancer (14) Endocrinology (2) Infection (1) Inflammation/Immunology (5) Metabolic Disease (1)
Click Chemistry:	PROTAC Synthesis (1)

Inhibitors & Agonists

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Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138253

2′,2′-Difluorodeoxyuridine dFdU; 2',2'-Difluoro-2'-deoxyuridine	Drug Metabolite Apoptosis	Cancer
2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells .

HY-B1320

Meclofenamic acid sodium Maximum Cited Publications 8 Publications Verification Meclofenamate sodium	Gap Junction Protein Endogenous Metabolite Fat Mass and Obesity-associated Protein (FTO)	Inflammation/Immunology Cancer
Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .

HY-50868

Bafetinib Maximum Cited Publications 14 Publications Verification INNO-406; NS-187	Bcr-Abl Src Apoptosis	Cancer
Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph ⁺ leukemia cells. Bafetinib has antitumor activity .

HY-N2609

7,4'-Dihydroxyflavone 4 Publications Verification	COX CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

HY-N10549

Gigantol 1 Publications Verification	Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3	Infection Metabolic Disease Cancer
Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .

HY-138253S

2′,2′-Difluorodeoxyuridine-13C,15N2 dFdU-¹³C,¹⁵N₂; 2',2'-Difluoro-2'-deoxyuridine-¹³C,¹⁵N₂	Isotope-Labeled Compounds Drug Metabolite Apoptosis	Others
2′,2′-Difluorodeoxyuridine- ¹³C, ¹⁵N₂ (dFdU- ¹³C, ¹⁵N₂) is a ¹³C- and ¹⁵N-labeled compound. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells .

HY-138253R

2′,2′-Difluorodeoxyuridine (Standard) dFdU (Standard); 2',2'-Difluoro-2'-deoxyuridine (Standard)	Drug Metabolite Reference Standards Apoptosis	Cancer
2′,2′-Difluorodeoxyuridine (Standard) is the analytical standard of 2′,2′-Difluorodeoxyuridine. This product is intended for research and analytical applications. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells.

HY-N2609R

7,4'-Dihydroxyflavone (Standard)	COX Reference Standards CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .

HY-122552

Chrysotobibenzyl	Integrin	Cancer
Chrysotobibenzyl can be isolated from stem of Dendrobium pulchellum. Chrysotobibenzyl inhibits lung cancer cell (H460 and H292) migration, invasion, filopodia formation via Cav-1, integrins β1, β3, and αν, and EMT suppressions. Chrysotobibenzyl also sensitizes lung cancer cell death mediated by Cisplatin (HY-17394) .

HY-153259

TNKS1/2-IN-2	TNK1 PARP	Cancer
TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC₅₀ values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC₅₀ values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer .

HY-176435

mTOR inhibitor-28	mTOR	Cancer
mTOR inhibitor-28 (SM-3) is a potent mTOR inhibitor. mTOR inhibitor-28 inhibits A549, H292, and H460 cells with IC₅₀s of 72.74, 67.66, and 43.24 μM, respectively .

HY-174314

WZH-15-125	Ligands for Target Protein for PROTAC Anaplastic lymphoma kinase (ALK)	Cancer
WZH-15-125 is a potent ALK inhibitor. WZH-15-125 can effectively overcome drug resistance, especially compound ALK mutations. WZH-15-125 has an IC₅₀ of 101.7 nM for the highly refractory G1202R/L1196M mutation that is resistant to Lorlatinib (HY-12215). WZH-15-125 can be used as a PROTAC target protein ligand to synthesize PROTAC WZH-17-002 (HY-174315). WZH-15-125 can be used in the research of non-small cell lung cancer .

HY-B1320R

Meclofenamic acid sodium (Standard) Meclofenamate sodium (Standard)	Reference Standards Gap Junction Protein Endogenous Metabolite Fat Mass and Obesity-associated Protein (FTO)	Inflammation/Immunology Cancer
Meclofenamic acid (sodium) (Standard) is the analytical standard of Meclofenamic acid (sodium). This product is intended for research and analytical applications. Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .

HY-50868R

Bafetinib (Standard) INNO-406 (Standard); NS-187 (Standard)	Bcr-Abl Src Apoptosis Reference Standards	Cancer
Bafetinib (Standard) is the analytical standard of Bafetinib. This product is intended for research and analytical applications. Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph+ leukemia cells. Bafetinib has antitumor activity .

HY-P99789

Praluzatamab ravtansine CX-2009; CD166	Antibody-Drug Conjugates (ADCs)	Cancer
Praluzatamab ravtansine (CX-2009) is an anti-CD166 antibody drug conjugate (ADC) with an K_d value of 25.15 nM. Praluzatamab ravtansine contains an anti-CD166 monoclonal antibody Praluzatamab (HY-P99788) conjugated to the microtubule inhibitor DM4 (HY-12454). Praluzatamab ravtansine shows tumor targeting and can be used for the study of lung cancer and breast cancer .

HY-153605

EGFR-IN-77	EGFR	Cancer
EGFR-IN-77 (Compound 4a) is a selective EGFR ^T790M/L858R inhibitor, with an IC₅₀ of 0.101 μM against EGFR ^T790M/L858R, 0.477 μM against EGFR ^L858R, and 1.771 μM against wild-type EGFR. EGFR-IN-77 exerts selective antiproliferative effects on EGFR ^T790M/L858R non-small cell lung cancer. EGFR-IN-77 can be used for the research of EGFR ^L858R/T790M double-mutant non-small cell lung cancer .

Cat. No.	Product Name	Target	Research Area

HY-P10087

Mouse TREM-1 SCHOOL peptide Mouse TREM-1(213–221), GF9	Peptides	Inflammation/Immunology Cancer
Mouse TREM-1 SCHOOL peptide (Mouse TREM-1(213-221), GF9) targets the interaction between TREM-1 and its signaling partner DAP-12, specifically silencing the TREM-1 signaling pathway, regulate the production of TREM-1-mediated pro-inflammatory cytokines in vivo and in vitro. Mouse TREM-1 SCHOOL peptide has anti-tumor effects. Mouse TREM-1 SCHOOL peptide can reduce the formation of vitreoretinal neovascularization .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1320

Meclofenamic acid sodium Maximum Cited Publications 8 Publications Verification Meclofenamate sodium	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	Gap Junction Protein Endogenous Metabolite Fat Mass and Obesity-associated Protein (FTO)
Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .

HY-N2609

7,4'-Dihydroxyflavone 4 Publications Verification	Flavonoids Classification of Application Fields Flavones Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Endocrinology Source Classification	COX CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

HY-N10549

Gigantol 1 Publications Verification	Structural Classification Classification of Application Fields Orchidaceae Other Diseases Phenols Polyphenols Glucosinolates Plants Disease Research Fields Dendrobium nobile Lindl.	Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3
Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .

HY-N2609R

7,4'-Dihydroxyflavone (Standard)	Structural Classification Flavonoids Flavones Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Source Classification	COX Reference Standards CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .

HY-122552

Chrysotobibenzyl	Natural Products Orchidaceae Plants Dendrobium pulchellum Roxb. et Lindl. :Lindl. Source Classification	Integrin
Chrysotobibenzyl can be isolated from stem of Dendrobium pulchellum. Chrysotobibenzyl inhibits lung cancer cell (H460 and H292) migration, invasion, filopodia formation via Cav-1, integrins β1, β3, and αν, and EMT suppressions. Chrysotobibenzyl also sensitizes lung cancer cell death mediated by Cisplatin (HY-17394) .

HY-B1320R

Meclofenamic acid sodium (Standard) Meclofenamate sodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Gap Junction Protein Endogenous Metabolite Fat Mass and Obesity-associated Protein (FTO)
Meclofenamic acid (sodium) (Standard) is the analytical standard of Meclofenamic acid (sodium). This product is intended for research and analytical applications. Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .

Cat. No.	Product Name	Chemical Structure

HY-138253S

2′,2′-Difluorodeoxyuridine-13C,15N2
2′,2′-Difluorodeoxyuridine- ¹³C, ¹⁵N₂ (dFdU- ¹³C, ¹⁵N₂) is a ¹³C- and ¹⁵N-labeled compound. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells .

2′,2′-Difluorodeoxyuridine-13C,15N2

2′,2′-Difluorodeoxyuridine- ¹³C, ¹⁵N₂ (dFdU- ¹³C, ¹⁵N₂) is a ¹³C- and ¹⁵N-labeled compound. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells .

Cat. No.	Product Name		Classification

HY-153605

EGFR-IN-77		PROTAC Synthesis
EGFR-IN-77 (Compound 4a) is a selective EGFR ^T790M/L858R inhibitor, with an IC₅₀ of 0.101 μM against EGFR ^T790M/L858R, 0.477 μM against EGFR ^L858R, and 1.771 μM against wild-type EGFR. EGFR-IN-77 exerts selective antiproliferative effects on EGFR ^T790M/L858R non-small cell lung cancer. EGFR-IN-77 can be used for the research of EGFR ^L858R/T790M double-mutant non-small cell lung cancer .

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H292

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products