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Results for "

HDM2

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

3

Peptides

2

Recombinant Proteins

6

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13424
    RITA
    3 Publications Verification

    NSC 652287

    		 MDM-2/p53 Autophagy DNA Alkylator/Crosslinker Cancer
    RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links.
    RITA
  • HY-110088
    SCH529074
    3 Publications Verification

    		 MDM-2/p53 Cancer
    SCH529074 is a potent and orally active p53 activator. SCH529074 binds specifically and conformation-dependently to p53 DBD ( DNA binding domain) with a Ki of 1-2 μM in a saturable manner. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. SCH529074 can be used for the study of non-small-cell lung carcinoma (NSCLC) [2].
    SCH529074
  • HY-P3508
    PNC-27

    		MDM-2/p53 Cancer
    PNC-27, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. PNC-27 is an anticancer peptide. PNC-27 can be used in acute myeloid leukemia research [2] .
    PNC-27
  • HY-108640A
    HLI373 dihydrochloride

    		MDM-2/p53 Parasite Apoptosis Infection Cancer
    HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents . Antimalarial activity [2].
    HLI373 dihydrochloride
  • HY-122886
    XL 188
    1 Publications Verification

    		 Deubiquitinase Cancer
    XL 188 is a potent and selective USP7 inhibitor with IC50 values of 90 nM and 193 nM for USP7 full-length and catalytic domain enzyme, respectively. XL 188 can be used in research of cancer .
    XL 188
  • HY-P3508A
    PNC-27 acetate

    		MDM-2/p53 Cancer
    PNC-27 acetate, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. PNC-27 acetate is an anticancer peptide. PNC-27 acetate can be used in acute myeloid leukemia research [2] .
    PNC-27 acetate
  • HY-108640
    HLI373

    		MDM-2/p53 Parasite Apoptosis Infection Cancer
    HLI373 is an efficacious Hdm2 inhibitor. HLI373 inhibits the ubiquitin ligase activity of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents . Antimalarial activity [2].
    HLI373
  • HY-131667
    Hdm2 E3 ligase inhibitor 1

    		MDM-2/p53 E1/E2/E3 Enzyme Cancer
    Hdm2 E3 ligase inhibitor 1 (Compound 1) is a reversible inhibitor for Hdm2 (an E3 ubiquitin ligase)-mediated ubiquitination of the p53 protein with an IC50 of 12.7 μM. Hdm2 E3 ligase inhibitor 1 binds Hdm2, blocks Hdm2-catalyzed ubiquitin transfer from preligated Ub-Ubc4 to p53, inhibits p53 ubiquitination, stabilizes p53 protein in tumor cell and exhibits antitumor efficacy .
    Hdm2 E3 ligase inhibitor 1
  • HY-145907
    p53-HDM2-IN-1

    		MDM-2/p53 Cancer
    p53-HDM2-IN-1 is a potent inhibitor of p53-HDM2 protein-protein interaction, with an IC50 of 0.103 μM. p53-HDM2-IN-1 can be used for the research of cancer .
    p53-HDM2-IN-1
  • HY-RS08264
    MDM2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    MDM2 Human Pre-designed siRNA Set A contains three designed siRNAs for MDM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MDM2 Human Pre-designed siRNA Set A
    MDM2 Human Pre-designed siRNA Set A
  • HY-139846
    MK-4688

    		MDM-2/p53 Cancer
    MK-4688 is an efficient inhibitor of the HDM2-p53 protein-protein interaction.
    MK-4688
  • HY-P11036
    p53-hDM2 cyclic peptide inhibitor 16e

    		MDM-2/p53 Cancer
    p53-hDM2 cyclic peptide inhibitor 16e is a p53-hDM2 cell-permeable peptide inhibitor with an IC50 of 9.24 nM for hDM2. p53-hDM2 cyclic peptide inhibitor 16e can be used for cancers like breast, colorectal and cervical cancers research .
    p53-hDM2 cyclic peptide inhibitor 16e
  • HY-18327
    HLI98C

    		E1/E2/E3 Enzyme MDM-2/p53 Cancer
    HLI98C is a ubiquitin ligase inhibitor. HLI98C inhibits p53 ubiquitylation. HLI98C inhibits HDM2 auto-ubiquitylation .
    HLI98C
  • HY-18329
    TDP-665759

    		MDM-2/p53 STAT Apoptosis Cancer
    TDP-665759 is an inhibitor for HDm2:p53 complex, and thus activates p53, inhibits STAT3 signaling pathway (EC50 of 5.90 μM) and the cell viability of p53 expressing A549R (IC50 of 7.02 μM). TDP-665759 induces apoptosis in HepG2. TDP-665759 exhibits antitumor efficacy in mouse models .
    TDP-665759
  • HY-150620
    BI-0282

    		MDM-2/p53 Cancer
    BI-0282 (Compound 1) is a potent MDM2-p53 interaction inhibitor .
    BI-0282
  • HY-RS11512
    R3HDM2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    R3HDM2 Human Pre-designed siRNA Set A contains three designed siRNAs for R3HDM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    R3HDM2 Human Pre-designed siRNA Set A
    R3HDM2 Human Pre-designed siRNA Set A
  • HY-180331
    NVP-CFC218

    		MDM-2/p53 Cancer
    NVP-CFC218 is a selective TP53-MDM2 inhibitor with a structure and biochemical profile similar to NVP-CGM097 (HY-15954) (IC50 of 1.6 nM: displacing the p53 peptide from the surface of HDM2). It is used to analyze pharmacological sensitivity in cell lines and is also applicable in cancer research [1] [2].
    NVP-CFC218
  • HY-W174480
    5-Deazaflavin

    		Drug Derivative Others
    5-deazaflavin is a flavin analogue with redox activity. 5-deazaflavin is a photocatalyst in biological redox systems [2].
    5-Deazaflavin

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