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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
HDR
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "HDR" in MCE Product Catalog:
21
21 Publications Verification
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SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .
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10 Cited Publications
Cat. No.: HY-19959
CAS No.: 1198097-97-0
Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells .
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2 Cited Publications
Cat. No.: HY-19334
CAS No.: 159182-43-1
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L755507 is a potent, selective agonist of β3-AR with an IC50 of 35 nM. L755507 enhances the homology-directed repair (HDR)-mediated genome editing .
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PolQi1 is a selective inhibitor targeting the Polθ domain of DNA polymerase. PolQi1 inhibits the Polθ-mediated microhomology end joining (TMEJ/alt-EJ) pathway, reducing insertion/deletion (Indels) and imprecise editing events during DNA repair. PolQi1 can enhance the efficiency and accuracy of homology-directed repair (HDR) or Prime editing, and reduce off-target effects; and in combination with DNA-PK inhibitor AZD-7648 (HY-111783), exert efficient genome editing capabilities with dual pathway regulation. PolQi1 can be mainly used in gene editing research (such as CRISPR-Cas9 or Prime editing system optimization) to improve the precision editing efficiency of difficult-to-edit cells (such as primary hepatocytes and mouse embryos) .
Cat. No.: HY-RS05291
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GATA3 Human Pre-designed siRNA Set A contains three designed siRNAs for GATA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P10068A
Cat. No.: HY-P4161
CAS No.: 292148-25-5
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Cat. No.: HY-107845R
CAS No.: 14892-97-8
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SCR7 pyrazine (Standard) is the analytical standard of SCR7 pyrazine (HY-107845). This product is intended for research and analytical applications. SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .
Cat. No.: HY-P86888
Synonyms: DCML antibody; Endothelial transcription factor GATA 2 antibody; Endothelial transcription factor GATA-2 antibody; GATA binding factor 3 antibody; GATA binding protein 2 antibody; GATA binding protein 3 antibody; GATA-binding protein 2 antibody; GATA-binding protein 3 antibody; HDR antibody; HDRS antibody; DCML antibody; Endothelial transcription factor GATA 2 antibody; Endothelial transcription factor GATA-2 antibody; GATA binding factor 3 antibody; GATA binding protein 2 antibody; GATA binding protein 3 antibody; GATA-binding protein 2 antibody; GATA-binding protein 3 antibody; HDR antibody; HDRS antibody; IMD21 antibody; MONOMAC antibody; NFE1B antibody; Trans acting T cell specific transcription factor GATA 3 antibody; Trans acting T cell specific transcription factor GATA-3 antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
