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Results for "

HDR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Apoptosis (3) ATM/ATR (1) DNA-PK (1) DNA/RNA Synthesis (4) Reference Standards (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (7) Endocrinology (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Peptides

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19959

Mirin 5+ Cited Publications	ATM/ATR Apoptosis	Cancer
Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC₅₀=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells .

HY-107845

SCR7 pyrazine Maximum Cited Publications 20 Publications Verification	DNA/RNA Synthesis Apoptosis	Cancer
SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .

HY-19334

L755507 2 Publications Verification	Adrenergic Receptor	Endocrinology Cancer
L755507 is a potent, selective agonist of β₃-AR with an IC₅₀ of 35 nM. L755507 enhances the homology-directed repair (HDR)-mediated genome editing .

HY-159078

PolQi1	DNA/RNA Synthesis	Cancer
PolQi1 is a selective inhibitor targeting the Polθ domain of DNA polymerase. PolQi1 inhibits the Polθ-mediated microhomology end joining (TMEJ/alt-EJ) pathway, reducing insertion/deletion (Indels) and imprecise editing events during DNA repair. PolQi1 can enhance the efficiency and accuracy of homology-directed repair (HDR) or Prime editing, and reduce off-target effects; and in combination with DNA-PK inhibitor AZD-7648 (HY-111783), exert efficient genome editing capabilities with dual pathway regulation. PolQi1 can be mainly used in gene editing research (such as CRISPR-Cas9 or Prime editing system optimization) to improve the precision editing efficiency of difficult-to-edit cells (such as primary hepatocytes and mouse embryos) .

HY-19977

YU238259	DNA-PK	Cancer
YU238259 is an inhibitor of homology-dependent DNA repair (HDR), used for cancer research.

HY-RS05291

GATA3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GATA3 Human Pre-designed siRNA Set A contains three designed siRNAs for GATA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GATA3 Human Pre-designed siRNA Set A GATA3 Human Pre-designed siRNA Set A

HY-P4161

KWWCRW	DNA/RNA Synthesis	Cancer
KWWCRW is a Holliday linker inhibitory peptide with anticancer activity. KWWCRW inhibits homologous recombination repair (HDR) during DNA repair by binding to the reactive Holliday linker intermediate and preventing its degradation, and inhibits site-specific recombination by bacteriophage in vitro .

HY-107845R

SCR7 pyrazine (Standard)	Reference Standards DNA/RNA Synthesis Apoptosis	Cancer
SCR7 pyrazine (Standard) is the analytical standard of SCR7 pyrazine (HY-107845). This product is intended for research and analytical applications. SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .

Cat. No.	Product Name	Target	Research Area

HY-P10068

LAH5	Peptides	Others
LAH5 is an amphipathic cell-penetrating peptide. LAH5 forms nanocomplexes with both RNP and RNP/HDR cargo .

HY-P10068A

LAH5 TFA	Peptides	Others
LAH5 TFA is an amphipathic cell-penetrating peptide. LAH5 THA forms nanocomplexes with both RNP and RNP/HDR cargo .

HY-P4161

KWWCRW	DNA/RNA Synthesis	Cancer
KWWCRW is a Holliday linker inhibitory peptide with anticancer activity. KWWCRW inhibits homologous recombination repair (HDR) during DNA repair by binding to the reactive Holliday linker intermediate and preventing its degradation, and inhibits site-specific recombination by bacteriophage in vitro .

Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Rat (2) Mouse (2)
Application:	IHC-P (4) ICC/IF (1) IP (1) WB (4) FC (2) ELISA (2)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84200

	GATA3 Antibody (YA3897) HDR; HDRS	WB, IHC-P, FC, ELISA	Human
	GATA3 Antibody (YA3897) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GATA3.

HY-P84200A

	GATA3 Antibody (YA3897)(PBS only) HDR; HDRS	WB, IHC-P, FC, ELISA	Human
	GATA3 Antibody (YA3897) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GATA3.

HY-P83022

	GATA2/3 Antibody (YA2767) DCML; GATA binding protein 2; GATA binding protein 3; HDR; HDRS; IMD21; MONOMAC; NFE1B	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	GATA2/3 Antibody (YA2767) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GATA2/3.

HY-P86888

	GATA2+GATA3 Antibody (YA6581) DCML antibody; Endothelial transcription factor GATA 2 antibody; Endothelial transcription factor GATA-2 antibody; GATA binding factor 3 antibody; GATA binding protein 2 antibody; GATA binding protein 3 antibody; GATA-binding protein 2 antibody; GATA-binding protein 3 antibody; HDR antibody; HDRS antibody; DCML antibody; Endothelial transcription factor GATA 2 antibody; Endothelial transcription factor GATA-2 antibody; GATA binding factor 3 antibody; GATA binding protein 2 antibody; GATA binding protein 3 antibody; GATA-binding protein 2 antibody; GATA-binding protein 3 antibody; HDR antibody; HDRS antibody; IMD21 antibody; MONOMAC antibody; NFE1B antibody; Trans acting T cell specific transcription factor GATA 3 antibody; Trans acting T cell specific transcription factor GATA-3 antibody;	WB, IHC-P	Human, Mouse, Rat
	GATA2+GATA3 Antibody (YA6581) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GATA2+GATA3.

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Cat. No.	Product Name		Classification

HY-RS05291

GATA3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GATA3 Human Pre-designed siRNA Set A contains three designed siRNAs for GATA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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