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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
HRR
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "HRR" in MCE Product Catalog:
Target:
Research Areas:
RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain). RECQL5-IN-1 is a potent inhibitor of RECQL5 helicase activity (IC50=46.3 nM), stabilizes the interaction between RECQL5-RAD51 proteins, causes RAD51 aggregation and homologous recombination repair (HRR) inhibition, thereby exhibiting selective cytotoxicity in RECQL5-expressing cancer cells .
Cat. No.: HY-P703605
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NR1H4; Farnesol Receptor HRR-1; Nuclear Receptor Subfamily 1 Group H Member 4; HRR-1; Bile Acid Receptor; RXR-Interacting Protein 14; RIP14; BAR; HRR1; Nuclear Receptor Subfamily 1, Group H, Member 4; FXR; Farnesoid X Nuclear Receptor; Retinoid X Receptor
Species:
Human
Source:
E. coli
Cat. No.: HY-P703606
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NR1H4; Farnesol Receptor HRR-1; Nuclear Receptor Subfamily 1 Group H Member 4; HRR-1; Bile Acid Receptor; RXR-Interacting Protein 14; RIP14; BAR; HRR1; Nuclear Receptor Subfamily 1, Group H, Member 4; FXR; Farnesoid X Nuclear Receptor; Retinoid X Receptor
Species:
Human
Source:
E. coli
Cat. No.: HY-P702878
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NR1H4; Farnesol Receptor HRR-1; Nuclear Receptor Subfamily 1 Group H Member 4; HRR-1; Bile Acid Receptor; RXR-Interacting Protein 14; RIP14; BAR; HRR1; Nuclear Receptor Subfamily 1, Group H, Member 4; FXR; Farnesoid X Nuclear Receptor; Retinoid X Receptor
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705557
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Bile acid receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14; NR1H4; FXR; BAR; HRR1; RIP14
Species:
Human
Source:
E. coli
Cat. No.: HY-183630
CAS No.: 3045469-78-8
Target:
Research Areas:
AZD4956 is a potent and selective DNA polymerase theta (POLQ) inhibitor. AZD4956 exhibits an IC50 value of less than 3 μmol/L against POLQ and 3.4 μmol/L against MMEJ. AZD4956 suppresses the MMEJ pathway and enhances the activity of DNA-damaging agents in HRR-deficient cellular contexts. AZD4956 shows antitumor activity in BRCA1/2-mutated triple-negative breast cancer and prostate cancer models. AZD4956 can be used for the study of homologous recombination-deficient tumors .
Cat. No.: HY-181254
CAS No.: 3084810-86-3
Target:
Research Areas:
PARP1/NAMPT-IN-1 is a potent and dual PARP1 and NAMPT inhibitor with IC50 values of 1.2 nM and 6.7 nM, respectively. PARP1/NAMPT-IN-1 can disrupt the homologous recombination repair (HRR) pathway, leading to the accumulation of DNA double-strand breaks (DSBs), inducing cell cycle arrest and apoptosis, and also has antimigratory effects. PARP1/NAMPT-IN-1 exhibits excellent antitumor effects in a breast cancer xenograft model. PARP1/NAMPT-IN-1 can be used for the study of triple-negative breast cancer (TNBC) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
