119 Results for "

HaCaT cell

" in MedChemExpress (MCE) Product Catalog:
Products (119)

119 Results for "HaCaT cell" in MCE Product Catalog:

42
Citric acid
Citric acid
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42 Publications Verification
Cat. No.: HY-N1428
CAS No.: 77-92-9
Category:  

Cardiovascular Disease Preservatives Anti-aging Metabolic Disease Endocrine diseases Endogenous metabolite Food Research Infection Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Inflammation/Immunology Cancer

Target:  

Environmental Pollutants Endogenous Metabolite Bacterial Apoptosis

Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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13
Citric acid trisodium
Citric acid trisodium
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13 Cited Publications
Cat. No.: HY-B2201
CAS No.: 68-04-2
Synonyms: Sodium citrate; Trisodium citrate anhydrous
Citric acid trisodium (Sodium citrate) is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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13
Citric acid tripotassium hydrate
Citric acid tripotassium hydrate
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13 Cited Publications
Cat. No.: HY-W009156
CAS No.: 6100-05-6
Synonyms: Potassium citrate monohydrate
Category:  

Ketones, Aldehydes, Acids Guttiferae Metabolic Disease Plants Garcinia cambogia Disease Research Fields Inflammation/Immunology

Target:  

Environmental Pollutants Endogenous Metabolite Bacterial Apoptosis

Citric acid tripotassium hydrate (Potassium citrate monohydrate) is a natural preservative and food tartness enhancer. Citric acid tripotassium hydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid tripotassium hydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid tripotassium hydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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13
Lithium citrate tetrahydrate
Lithium citrate tetrahydrate
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13 Cited Publications
Cat. No.: HY-B1295
CAS No.: 6080-58-6
Synonyms: Litarex tetrahydrate
Category:  

Infection Microorganisms Ketones, Aldehydes, Acids Disease Research Fields

Target:  

Apoptosis Endogenous Metabolite Bacterial

Lithium citrate (Litarex) tetrahydrate is a natural preservative and food tartness enhancer. Lithium citrate tetrahydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Lithium citrate tetrahydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Lithium citrate tetrahydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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10
Citric acid monohydrate
Citric acid monohydrate
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10 Cited Publications
Cat. No.: HY-N1428A
CAS No.: 5949-29-1
Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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8
α-Tocopherol phosphate disodium
α-Tocopherol phosphate disodium
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8 Cited Publications
Cat. No.: HY-W127530
CAS No.: 60934-46-5
Synonyms: alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium
α-Tocopherol phosphate disodium is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium exhibits angiogenesis-promoting activity .
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3
Khasianine
Khasianine
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3 Cited Publications
Cat. No.: HY-N2322
CAS No.: 32449-98-2
Category:  

Alkaloids Piperidine Alkaloids Solanum nigrum Linn. Plants Solanaceae Disease Research Fields Cancer

Target:  

TNF Receptor NF-κB ROCK

Khasianine is a steroidal glycoalkaloid . Khasianine alleviates psoriasis-like skin inflammation by inhibiting the TNF-α/NF-κB axis. Khasianine can downregulate the RhoA pathway and exhibits potential antimetastatic activity. Khasianine upregulates the expression of TNFR I and TNFR II without inducing apoptotic effects . Khasianine can be used in studies related to psoriasis, pancreatic ductal adenocarcinoma, and liver cancer .
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2
(+)-Columbianetin
(+)-Columbianetin
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2 Cited Publications
Cat. No.: HY-N0363
CAS No.: 3804-70-4
Synonyms: (S)-Columbianetin
Category:  

Coumarins Phenylpropanoids Plants Umbelliferae Seriphidium transiliense Disease Research Fields Inflammation/Immunology

Target:  

ERK JNK Collagen TGF-beta/Smad p38 MAPK Reactive Oxygen Species (ROS)

(+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging .
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2
(+)-Columbianetin acetate
(+)-Columbianetin acetate
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2 Cited Publications
Cat. No.: HY-N0363A
CAS No.: 23180-65-6
Synonyms: (S)-Columbianetin acetate
Category:  

other families Coumarins Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Fungal

(+)-Columbianetin ((S)-Columbianetin) acetate acts as an inhibitor of JNK/ERK. (+)-Columbianetin acetate inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin acetate regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin acetate is applicable to research related to skin aging .
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2
(E)-Osmundacetone
(E)-Osmundacetone
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2 Cited Publications
Cat. No.: HY-N1966
CAS No.: 123694-03-1
Category:  

Microorganisms Phenols Polyphenols

Target:  

p38 MAPK PPAR

(E)-Osmundacetone is an inhibitor of the MAPK pathway. (E)-Osmundacetone inhibits the activation of the MAPK signaling pathway and restores the expression of PPARα/ACOX1. (E)-Osmundacetone abrogates abnormal cell proliferation, migration and liver metastasis induced by PTPRO silencing in colorectal cancer cells. (E)-Osmundacetone blocks OA-RD17-mediated activation of the MAPK signaling pathway, thereby reducing macrophage proliferation and migration. (E)-Osmundacetone is applicable to relevant research on colorectal cancer .
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1
3′,4′,7-Trihydroxyflavone
3′,4′,7-Trihydroxyflavone
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1 Cited Publications
Cat. No.: HY-N2736
CAS No.: 2150-11-0
Category:  

Flavonoids Leguminosae Flavones Other Diseases Phenols Polyphenols Plants Vicia faba L. Disease Research Fields

Target:  

Beta-lactamase COX Interleukin Related Bacterial JNK ERK p38 MAPK STAT Apoptosis NO Synthase Nuclear Factor of activated T Cells (NFAT) Lactate Dehydrogenase Reactive Oxygen Species (ROS) SOD Akt Caspase Bcl-2 Family

3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC50 = 1.89 μM) and COX-1 (IC50 = 36.37 μM). 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H2O2-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice .
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1
Retusin
Retusin
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1 Cited Publications
Cat. No.: HY-N6829
CAS No.: 1245-15-4
Synonyms: Quercetin-​3,​3',​4',​7-​tetramethylether
Category:  

Flavonols Flavonoids Monophenols Entada phaseoloides (L.) Merr. Labiatae Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Tyrosinase Fungal SARS-CoV Apoptosis Reactive Oxygen Species (ROS)

Retusin (Quercetin-3,3',4',7-tetramethylether) is a tyrosinase inhibitor, with IC50 values of 50.9 μM and 51.8 μM against mushroom and intracellular tyrosinase, respectively. Retusin also acts as a free radical scavenger, melanogenesis inhibitor, anti-apoptosis agent, neuroprotective agent, antiemetic, antifungal agent, and antiviral agent. Retusin scavenges ABTS• + and DPPH• free radicals. Retusin can be used in studies related to hyperpigmentation, vomiting, Aspergillus niger infection, and COVID-19 infection .
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1
7,8-Dimethoxycoumarin
7,8-Dimethoxycoumarin
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1 Cited Publications
Cat. No.: HY-N4280
CAS No.: 2445-80-9
Category:  

Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Citrus reticulata Blanco

Target:  

Na+/K+ ATPase Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related

7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H +/K +-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis .
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Citric acid-13C6
Citric acid-13C6
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Cat. No.: HY-N1428S1
CAS No.: 287389-42-8
Citric acid- 13C6 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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Lactoferrin from Bovine milk
Lactoferrin from Bovine milk
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Cat. No.: HY-P3161
CAS No.: 936541-36-5
Lactoferrin from Bovine milk is a substance released by neutrophils. Lactoferrin from Bovine milk is an orally active multifunctional iron binding glycoprotein. Lactoferrin from Bovine milk prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin from Bovine milk also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin from Bovine milk has anti-inflammatory, immunomodulatory, and anti-cancer activities .
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Citric acid-d4
Citric acid-d4
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Cat. No.: HY-N1428S
CAS No.: 147664-83-3
Citric acid-d4 is the deuterium labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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DSPE-PEG2000-Folate
DSPE-PEG2000-Folate
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Cat. No.: HY-W440888
DSPE-PEG2000-Folate (DSPE-PEG2000 Folate) is a folate-containing PEG derivative. DSPE-PEG2000-Folate possesses targeting activity and binds to folate receptors in cancer cells. DSPE-PEG2000-Folate can be post-inserted into preformed liposomal bilayers to prepare folate-targeted liposomal formulations. DSPE-PEG2000-Folate forms micelles/lipid bilayers and can be used in studies of targeted drug delivery systems [2].
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Trifloxystrobin
Trifloxystrobin
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Cat. No.: HY-123230
CAS No.: 141517-21-7
Purity:  99.49%
Synonyms: CGA 279202
Target:  

Environmental Pollutants Fungal Caspase Apoptosis PARP

Research Areas:  

Infection Neurological Disease

Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases .
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Gomisin D
Gomisin D
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Cat. No.: HY-N2413
CAS No.: 60546-10-3
Category:  

Lignans Metabolic Disease Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.

Target:  

PDGFR UGT Reactive Oxygen Species (ROS) Apoptosis Tyrosinase p38 MAPK Akt ERK COX Interleukin Related

Gomisin D is an orally active lignan that binds to PDGFRβ with a Kd of 10 μM. By targeting PDGFRβ to regulate signaling pathways, Gomisin D inhibits the activation and proliferation of hepatic stellate cells and promotes their apoptosis, thereby ameliorating hepatic fibrosis. Gomisin D exhibits multiple activities such as photoprotection, antimelanogenesis, antioxidant effects, and hypoglycemic activity. Gomisin D can be used in studies related to diabetes, Alzheimer's disease, and hepatic fibrosis .
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Guar gum
Guar gum
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Cat. No.: HY-W145516
CAS No.: 9000-30-0
Target:  

Environmental Pollutants Biochemical Assay Reagents

Research Areas:  

Metabolic Disease

Guar gum is an orally active nonionic galactomannan polysaccharide. It is present in the endosperm of Cyamopsis tetragonolobus seeds. Guar gum reduces cholesterol levels, regulates body weight, and acts as a thickener and viscosity modifier by forming hydrogen-bonded aqueous solutions. It serves as a rate-controlling excipient in compound delivery systems, and finds applications in the food, tissue engineering, nanosensing and industrial fields .
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