10 Results for "

Hdp

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "Hdp" in MCE Product Catalog:

  • Isoforms Recommended:
6
6 Cited Publications
Cat. No.: HY-14532
CAS No.: 444805-28-1
Purity:  99.46%
Synonyms: CMX001; Hdp-CDV
Target:  

CMV HSV Orthopoxvirus

Research Areas:  

Infection

Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo .
loading...
    loading...
Cat. No.: HY-113366
CAS No.: 60203-57-8
Purity:  98.10%
Synonyms: PGJ2
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) .
loading...
    loading...
Cat. No.: HY-16635
CAS No.: 866460-33-5
Synonyms: ACT-129968; KYTH-105
Setipiprant (ACT-129968) is an orally active and selective CRTH2 antagonist. Setipiprant interacts with hCRTH2 receptor with an IC50 value of 6 nM. Setipiprant inhibits prostanoid receptors hDP1 and hEP2 with IC50 values of 1290 and 2600 nM, respectively. Setipiprant can be used for the research of asthma and rhinitis .
loading...
    loading...
Cat. No.: HY-P11107
CAS No.: 2375823-45-1
Target:  

Apoptosis TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

RP-832c is a synthetic analogue of host defense peptides (HDP), targeting the mannose receptor CD206 on the surface of M2 polarized macrophages (Kd = 3.5 μM). RP-832c binding to CD206 induces a significant conformational change in the receptor, activating signaling pathways that lead to rapid apoptosis and repolarization of CD206-positive M2 macrophages to an M1 phenotype. RP-832c treatment significantly reduces CD206 gene expression in M2 macrophages while transiently increasing expression of TNF-α, a marker for M1 macrophages. RP-832c is used for the studies of T-cell lymphoma (CTCL) and idiopathic pulmonary fibrosis (IPF) .
loading...
    loading...
Cat. No.: HY-14532S
CAS No.: 1917374-64-1
Synonyms: CMX001-d6; Hdp-CDV-d6
Brincidofovir-d6 (CMX001-d6) is the deuterium labeled Brincidofovir (HY-14532). Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo. .
loading...
    loading...
Cat. No.: HY-171015
CAS No.: 235097-47-9
Synonyms: Hdp
Research Areas:  

Others

10-(Phosphonooxy)-1-decanole (10-Hydroxydecyl dihydrogen phosphate) is a hydrolysis product of 10-Methacryloyloxydecyl dihydrogen phosphate .
loading...
    loading...
Cat. No.: HY-122147
CAS No.: 72313-41-8
Research Areas:  

Metabolic Disease

L-644698 is a potent and selective human recombinant prostaglandin D2 (PGD2) receptor (hDP) agonist with Ki values of 0.9, 267, 3730, 9280 nM for hDP, hEP2, hEP3, hEP4, respectively. L-644698 induces cyclic AMP production with an EC50 value of 0.5 nM .
loading...
    loading...
Cat. No.: HY-P5842
Research Areas:  

Infection

Citrullinated LL-37 3cit is a host defense peptide (HDP) with broad immunomodulatory and antimicrobial activities. Citrullinated LL-37 3cit exhibits direct antiviral effects against human rhinoviruses (HRV) .
loading...
    loading...
Cat. No.: HY-RS19543
Research Areas:  

Others

Hnrnpa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hnrnpa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-16635R
CAS No.: 866460-33-5
Synonyms: ACT-129968 (Standard); KYTH-105 (Standard)
Setipiprant (Standard) is the analytical standard of Setipiprant. This product is intended for research and analytical applications. Setipiprant (ACT-129968) is an orally active and selective CRTH2 antagonist. Setipiprant interacts with hCRTH2 receptor with an IC50 value of 6 nM. Setipiprant inhibits prostanoid receptors hDP1 and hEP2 with IC50 values of 1290 and 2600 nM, respectively. Setipiprant can be used for the research of asthma and rhinitis .
loading...
    loading...