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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
55 Results for "
Human Kallikrein
" in MedChemExpress (MCE) Product Catalog:
Products (55)
55 Results for "Human Kallikrein" in MCE Product Catalog:
Cat. No.: HY-E70389
Target:
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Human Kallikrein is a serine protease that can be found in plasma and tissue. Human Kallikrein has the potential for the research of blood pressure, complement activation, and mediation and maintenance of inflammatory responses .
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Sebetralstat (KVD900) is an orally active and selective plasma kallikrein inhibitor, with an IC50 of 6.0 nM and a Ki of 3.0 nM against the human target. Sebetralstat binds to the active site of plasma kallikrein, inducing a conformational flip of Trp215 to form a U-shaped conformation; its P1 group interacts with the S1 pocket through hydrophobic interactions and displacement of high-energy water molecules, independent of the Asp189 ionic bond. Sebetralstat inhibits plasma kallikrein-kinin system activation in whole plasma, rapidly relieves laryngeal and abdominal attack symptoms of hereditary angioedema (HAE-C1INH), and reduces attack severity. Sebetralstat can be used in research related to hereditary angioedema (HAE) .
1
1 Cited Publications
Cat. No.: HY-P70606A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KLK3; Kallikrein 3, (Prostate Specific Antigen), Isoform CRA_e; Prev. APS; Kallikrein 3, (Prostate Specific Antigen), Isoform CRA_d; PSA; Kallikrein 3, (Prostate Specific Antigen), Isoform CRA_f; Prostate Specific Antigen; Kallikrein 3, (Prostate Specific
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P70266
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KLK3; Kallikrein 3, (Prostate Specific Antigen), Isoform CRA_e; Prev. APS; Kallikrein 3, (Prostate Specific Antigen), Isoform CRA_d; PSA; Kallikrein 3, (Prostate Specific Antigen), Isoform CRA_f; Prostate Specific Antigen; Kallikrein 3, (Prostate Specific
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71143
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINA4; Testicular Secretory Protein Li 22; Prev. PI4; Peptidase Inhibitor 4; KST; Kallikrein Inhibitor; Kallistatin; Serpin A4; KLST; PI-4; KAL; Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4, Isoform CRA_a; Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4; Protease Inhibitor 4 (Kallistatin); Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4; Serpin Family A Member 4; Sserpin Family A Member 4
Species:
Human
Source:
HEK293
Cat. No.: HY-P991015
CAS No.: 2921676-04-0
Synonyms: JNJ-78278343; KLCB-245
Cat. No.: HY-P2618
CAS No.: 2237216-30-5
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Cat. No.: HY-137199
CAS No.: 65147-21-9
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Cat. No.: HY-P99110
CAS No.: 1426055-14-2
Synonyms: SHP643; DX-2930; X124-G01
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Target:
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BMS-962212 is a factor XIa (FXIa) inhibitor with a Ki of 0.7 nM against human FXIa and a Ki of 3 nM against rabbit FXIa. BMS-962212 blocks thrombosis while preserving normal hemostatic function. BMS-962212 is applicable to thrombosis-related research .
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Plasma kallikrein-IN-4 (Example 153) is a plasma kallikrein inhibitor with an IC50 of 0.016 μM against human plasma kallikrein .
Cat. No.: HY-122142A
CAS No.: 127428-47-1
Synonyms: S-2366 (hydrochloride)
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Pyr-Pro-Arg-pNA (S-2366) hydrochloride is a chromogenic peptidyl substrate, and a noncompetitive inhibitor that occupies the active sites of FXIa and FXIa-LC to block factor IX activation. Pyr-Pro-Arg-pNA hydrochloride functions as a hydrolyzable substrate for FXIa’s catalytic domain, human APC, murine APC, and purified plasma kallikrein .
Cat. No.: HY-P4331
CAS No.: 113865-85-3
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Cat. No.: HY-P10143
CAS No.: 99828-55-4
Synonyms: Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt
Cat. No.: HY-P4669
CAS No.: 1122484-55-2
Synonyms: BPR277
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Cat. No.: HY-P990459
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Cat. No.: HY-P991676
CAS No.: 2418159-10-9
Synonyms: DS-2325A
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Cat. No.: HY-150519
CAS No.: 1551460-43-5
Target:
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FXIa/Plasma kallikrein-IN-1 is an inhibitor of coagulation factor XIa (FXIa) and plasma kallikrein with Ki values of 187.70 nM and 151.6 nM, respectively. FXIa/Plasma kallikrein-IN-1 can be used in the research of thromboembolic diseases .
Synonyms: KVD-824
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Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC50 of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC50>40 μM) .
Cat. No.: HY-122142
CAS No.: 72194-57-1
Synonyms: S-2366
Target:
Research Areas:
Pyr-Pro-Arg-pNA (S-2366) is a chromogenic peptidyl substrate, and a noncompetitive inhibitor that occupies the active sites of FXIa and FXIa-LC to block factor IX activation. Pyr-Pro-Arg-pNA functions as a hydrolyzable substrate for FXIa’s catalytic domain, human APC, murine APC, and purified plasma kallikrein .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
