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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
Hypoxia-inducible factor 1
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "Hypoxia-inducible factor 1" in MCE Product Catalog:
73
73 Publications Verification
Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT
34
34 Cited Publications
Research Areas:
BAY 87-2243 is a highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.
26
26 Cited Publications
Cat. No.: HY-18777
CAS No.: 927822-86-4
Target:
Research Areas:
KC7F2 is a potent hypoxia inducible factor-1 (HIF-1) pathway inhibitor with an IC50 of 20 μM in LN229-HRE-AP cells, and with potential as a cancer therapy agent .
19
12
12 Cited Publications
Synonyms: Quinomycin A; NSC-13502
Research Areas:
Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM .
9
9 Cited Publications
Cat. No.: HY-P80704
Synonyms: HIF1A; BHLHE78; MOP1; PASD8; Hypoxia-inducible factor 1-alpha; HIF-1-alpha; HIF1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; bHLHe78; Member of PAS protein 1; PAS doma
4
4 Cited Publications
Cat. No.: HY-P74888
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HIF1A; Basic-Helix-Loop-Helix-PAS Protein MOP1; Hypoxia inducible factor 1 Subunit Alpha; HIF-1-Alpha; BHLHe78; Hypoxia inducible factor 1 Alpha Subunit; PASD8; Hypoxia-inducible factor1alpha; MOP1; Member Of PAS Superfamily 1; Class E Basic Helix-Loop-Helix Protein 78; ARNT Interacting Protein; Hypoxia-inducible factor 1-Alpha; ARNT-Interacting Protein; PAS Domain-Containing Protein 8; HIF1-ALPHA; Member Of PAS Protein 1; HIF1-Alpha; HIF-1alpha; BHLHE78; HIF1; HIF-1A; Hypoxia inducible factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription factor)
Species:
Human
Source:
E. coli
1
Chetomin, an active component of Chaetomium globosum, is a heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway inhibitor. Chetomin is a potent, nontoxic non-small cell lung cancer cancer stem cells (NSCLC CSC)-targeting molecule .
1
1 Cited Publications
Cat. No.: HY-P2324
CAS No.: 11029-61-1
Target:
Research Areas:
Mersalyl (Salirgan) is a potent vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) inducer. Mersalyl induces VEGF and ENO1 mRNA expression. Mersalyl shows diuresis effects .
Target:
Research Areas:
FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions .
Cat. No.: HY-P10426
CAS No.: 1446322-73-1
Target:
Research Areas:
Cat. No.: HY-N6905
CAS No.: 184673-79-8
Category:
Target:
Cat. No.: HY-16187
CAS No.: 1233948-61-2
Target:
Research Areas:
EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer .
Cat. No.: HY-P1888
CAS No.: 1201633-99-9
Target:
Research Areas:
Cat. No.: HY-16560S
CAS No.: 1329616-37-6
Synonyms: Campathecin-d5; (S)-(+)-Camptothecin-d5; CPT-d5
Cat. No.: HY-B0239S2
Synonyms: Campathecin (Standard); (S)-(+)-Camptothecin (Standard); CPT (Standard)
Cat. No.: HY-179341
CAS No.: 3104302-65-7
Target:
Research Areas:
CHNQD-03301 is an orally active hypoxia-inducible factor-1α (HIF-1α) inhibitor (IC50 = 10.97 nM). CHNQD-03301 promotes the proteasomal degradation of HIF-1α protein, leading to its significant suppression. CHNQD-03301 can reverse HIF accumulation-induced angiogenesis and mitigate the HIF-induced erythrocytosis phenotype in zebrafish models. CHNQD-03301 can be used for the study of colon cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
